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Journals / International Journal of Secondary Metabolite / 2019 / Cilt: 6 - Sayı: 1

Microwave-assisted synthesis of N-benzylidene-4-fluoroaniline and N-benzylidene4-Nitroaniline and their inhibitory activities on hCA isoenzymes

Hülya ÇELİK
Aynur BABAGİL
Pages
38–48
Publication Date
2022-10-19
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The results showed that the synthesized compounds 3a and 3b had a strong inhibitory effect on hCA-I and hCA-II enzymes activity in vitro.

📌 3 Key Takeaways

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Objective & Hypothesis:In this study, N-benzylidene-4-fluoroaniline (3a), N-benzylidene-4nitroaniline (3b) as a result of condensation of benzaldehyde (1) and 4fluoroaniline (2a), 4-nitroaniline (2b) using a microwave method was synthesized.
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Key Findings & Data:The results showed that the synthesized compounds 3a and 3b had a strong inhibitory effect on hCA-I and hCA-II enzymes activity in vitro.
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Conclusion & Impact:Thus, new therapeutic applications can be made for enzyme activators in the near future.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

In this study, N-benzylidene-4-fluoroaniline (3a), N-benzylidene-4nitroaniline (3b) as a result of condensation of benzaldehyde (1) and 4fluoroaniline (2a), 4-nitroaniline (2b) using a microwave method was synthesized. The structures of the synthesized compounds were characterized by Fouirer Transform İnfrared Spektrofotometre (FTIR spectroscopy), Nuclear Magnetic Resonance (NMR spectroscopy) and elemental analysis methods. The prepared compounds were tested for their inhibitory effects on carbonic anhydrase isoenzymes (hCA-I and hCA-II). The results showed that the synthesized compounds 3a and 3b had a strong inhibitory effect on hCA-I and hCA-II enzymes activity in vitro. By testing these compounds in other CA isoenzymes, more effective CA inhibitors can be formed. Thus, new therapeutic applications can be made for enzyme activators in the near future.

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Cite This Article

ÇELİK, H., BABAGİL, A. (2022). Microwave-assisted synthesis of N-benzylidene-4-fluoroaniline and N-benzylidene4-Nitroaniline and their inhibitory activities on hCA isoenzymes. International Journal of Secondary Metabolite, Cilt: 6 - Sayı: 1, 38–48. https://ajindex.com/articles/541653

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