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Dergiler / International Journal of Secondary Metabolite / 2019 / Cilt: 6 - Sayı: 1

Microwave-assisted synthesis of N-benzylidene-4-fluoroaniline and N-benzylidene4-Nitroaniline and their inhibitory activities on hCA isoenzymes

Hülya ÇELİK
Aynur BABAGİL
Sayfa
38–48
Yayın Tarihi
2022-10-19
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Thus, new therapeutic applications can be made for enzyme activators in the near future.

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Amaç & Hipotez:In this study, N-benzylidene-4-fluoroaniline (3a), N-benzylidene-4nitroaniline (3b) as a result of condensation of benzaldehyde (1) and 4fluoroaniline (2a), 4-nitroaniline (2b) using a microwave method was synthesized.
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Temel Bulgular & Veri:The results showed that the synthesized compounds 3a and 3b had a strong inhibitory effect on hCA-I and hCA-II enzymes activity in vitro.
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Sonuç & Katkı:Thus, new therapeutic applications can be made for enzyme activators in the near future.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Abstract

In this study, N-benzylidene-4-fluoroaniline (3a), N-benzylidene-4nitroaniline (3b) as a result of condensation of benzaldehyde (1) and 4fluoroaniline (2a), 4-nitroaniline (2b) using a microwave method was synthesized. The structures of the synthesized compounds were characterized by Fouirer Transform İnfrared Spektrofotometre (FTIR spectroscopy), Nuclear Magnetic Resonance (NMR spectroscopy) and elemental analysis methods. The prepared compounds were tested for their inhibitory effects on carbonic anhydrase isoenzymes (hCA-I and hCA-II). The results showed that the synthesized compounds 3a and 3b had a strong inhibitory effect on hCA-I and hCA-II enzymes activity in vitro. By testing these compounds in other CA isoenzymes, more effective CA inhibitors can be formed. Thus, new therapeutic applications can be made for enzyme activators in the near future.

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Bu Makaleye Atıf Yap

ÇELİK, H., BABAGİL, A. (2022). Microwave-assisted synthesis of N-benzylidene-4-fluoroaniline and N-benzylidene4-Nitroaniline and their inhibitory activities on hCA isoenzymes. International Journal of Secondary Metabolite, Cilt: 6 - Sayı: 1, 38–48. https://ajindex.com/articles/541653

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