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Journals / Hittite Journal of Science and Engineering / 2017 / Cilt: 4 - Sayı: 1

Evaluation of Chitosan /Organoclay Composite as Bone Tissue Engineering Scaffold

Aysel KOÇ DEMİR
Pages
45–49
Publication Date
2022-10-18
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Based on the results, we conclude that the characterized C/OC composite system may have potential for use in bone tissue engineering applications

📌 3 Key Takeaways

🎯
Objective & Hypothesis:I n this study, a scaffold composed of chitosan C and organoclay OC was prepared by utilizing freeze-drying method.
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Key Findings & Data:The in vivo cytocompatibility of the composite was evaluated in vivo, by seeding MC3T3-E1 cells on composite scaffolds.
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Conclusion & Impact:Based on the results, we conclude that the characterized C/OC composite system may have potential for use in bone tissue engineering applications
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Bone tissue engineering · Chitosan · Organoclay

Abstract

I n this study, a scaffold composed of chitosan C and organoclay OC was prepared by utilizing freeze-drying method. The composition of resulting composite scaffold was evaluated using FTIR and SEM. The in vivo cytocompatibility of the composite was evaluated in vivo, by seeding MC3T3-E1 cells on composite scaffolds. In-vitro cell viability and proliferation were investigated using the MTT assay, while cell-scaffold constructs were evaluated using scanning electron microscopy. Preliminary in vivo experiments were also performed to evaluate tissue compatibility and ectopic boneforming potential of C/OC composite scaffolds with MC3T3-E1 cells. The findings suggest that C/OC construct supported the proliferation of MC3T3-E1 cells, presented histobiocompatibility and promoted formation of calcified matrix. Based on the results, we conclude that the characterized C/OC composite system may have potential for use in bone tissue engineering applications

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Cite This Article

DEMİR, A. K. (2022). Evaluation of Chitosan /Organoclay Composite as Bone Tissue Engineering Scaffold. Hittite Journal of Science and Engineering, Cilt: 4 - Sayı: 1, 45–49. https://ajindex.com/articles/538068

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