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Journals / Hittite Journal of Science and Engineering / 2018 / Cilt: 5 - Sayı: 4

Combinations of Interleukin-10 Gene Promoter Polymorphisms with -1082A, -819T, -592A Minor Allele are Associated with Sinonasal Polyposis.

Sibel OZDAS
Pages
285–292
Publication Date
2022-10-18
DOI
—
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

The IL-10 gene promoter polymorphisms with -1082A,-819T, -592A minor alleles, their heterozygotes and homozygotes mutant genotypes hadsignificantly higher risks for SP (P

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Sinonasal polyposis (SP) is an inflammatory disease involving multiple etiologies andpathogenesis.
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Key Findings & Data:The disarray of Interleukin (IL)-10 is associated with a raised immunopathologicalresponse during the progression of many autoimmune diseases as well as theresponse to infection.
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Conclusion & Impact:The IL-10 gene promoter polymorphisms with -1082A,-819T, -592A minor alleles, their heterozygotes and homozygotes mutant genotypes hadsignificantly higher risks for SP (P
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Sinonasal polyposis (SP) is an inflammatory disease involving multiple etiologies andpathogenesis. The disarray of Interleukin (IL)-10 is associated with a raised immunopathologicalresponse during the progression of many autoimmune diseases as well as theresponse to infection. We studied the possible role of the single nucleotide polymorphisms(SNPs) in IL-10 gene and their genotypic combinations in the SP pathogenesis. The IL-10’spromoter was genotyped in 200 participants (100 patients and 100 controls). The sites thatwere encompassed -1082, -819, and -592 SNP regions of extracted DNAs were analyzedby sequencing for polymorphisms. The IL-10 gene promoter polymorphisms with -1082A,-819T, -592A minor alleles, their heterozygotes and homozygotes mutant genotypes hadsignificantly higher risks for SP (P

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Cite This Article

OZDAS, S. (2022). Combinations of Interleukin-10 Gene Promoter Polymorphisms with -1082A, -819T, -592A Minor Allele are Associated with Sinonasal Polyposis.. Hittite Journal of Science and Engineering, Cilt: 5 - Sayı: 4, 285–292. https://ajindex.com/articles/538061

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