AI Summary & Key Takeaways
AI InsightConclusion: Photodynamic therapy with verteporfin is effective and successful in preserving visual acuity in subfoveal choroidal neovascular membranes due to age related macular degeneration.
📌 3 Key Takeaways
Abstract
Purpose: To evaluate the results of photodynamic therapy (PDT) with verteporfin in subfoveal choroidal neovascular membranes due to age related macular degeneration. Materials and methods: Sixty eyes of 50 patients who had photodynamic therapy with verteporfin (Visudyne ® Novartis-Switzerland)for subfoveal choroidal neovascular membrane between April 2005 and May 2007 at Haydarpafla Numune Training and Research Hospital, Eye Clinic 2 were included in this study. Initial and last best corrected visual acuities were examined with Early Treatment Diabetic Retinopathy Study (ETDRS) chart. Ophthalmic examination and fundus fluorescein angiography (FFA) findings were recorded. Cases were divided into three groups as predominantly classic, minimally classic and occult choroidal neovascular membranes on the basis of fundus fluorescein angiography findings. After the therapy cases were controlled at first and third months and then at three month intervals. Fortyfour eyes had 1, 3 eyes had 2, 4 eyes had 3,5 eyes had 4 and 4 eyes had 5 times photodynamic therapy. Results: Mean age of the patients included in the study was 68.6±8.12 years. Twenty seven of 50 patients were female (54%), 23 were male (46%). According to the FFA findings 30 (50%) cases had predominantly classic, 11 (18.3%) cases had minimally classic and 19 (31.7%) cases had occult choroidal neovascular membranes. According to logMAR mean initial best corrected visual acuities were 0.84±0.38 (0.30- 1.80). Acoording to logMAR mean final best corrected visual acuities were 0.78±0.46 (0.10-1.60). There were no statistically siginificant differences among the changes of mean visula acuity according to lesion types (p>0.05). There was a statistically significant positive correlation between the initial and final best corrected visual acuities. Conclusion: Photodynamic therapy with verteporfin is effective and successful in preserving visual acuity in subfoveal choroidal neovascular membranes due to age related macular degeneration.
Özet
Amaç: Yaşa balı makula dejenerasyonu sonucu gelişen subfoveal koroidal neovaskuler membranların verteporfin ile fotodinamik tedavi (PDT) sonuclarını deerlendirmek. Gereç ve Yöntem: Haydarpaşa Numune Eitim ve Araştırma Hastanesi 2.Goz Klinii’nde Nisan 2005- Mayıs 2007 tarihleri arasında verteporfin (VisudyneR Novartis-‹svicre) ile fotodinamik tedavi uygulanan, yaşa balı subfoveal koroidal neovaskuler membranı olan 50 hastanın 60 gozu calışmaya dahil edildi. Olguları n başlangıc ve sonuc en iyi gorme keskinlikleri Early Treatment Diabetic Retinopathy Study (ETDRS) eşeli ile alındı. Oftalmolojik muayene ve fundus şoresein anjiografi (FFA) bulguları kayıt edildi. Olgular anjiografi bulgularına gore baskın klasik, minimal klasik ve gizli koroidal neovaskuler membran olarak uc gruba ayrıldı. Tedavi sonrası olgular birinci ve ucuncu aylarda, daha sonraki takiplerde ise ucer ay aralarla kontrollere alındı. Kırkdort goze 1 kez, 3 goze 2 kez, 4 goze 3 kez, 5 goze 4 kez ve 4 goze de 5 kez fotodinamik tedavi uygulandı. Bulgular: Calışmaya dahil edilen hastaların yaş ortalamaları 68.6 }8.12 yıl idi. Elli hastanın 27’si (%54) kadı n, 23’u (%46) erkekti. FFA bulgularına gore olguları n 30’u (%50) baskın klasik, 11’i (%18.3) minimal klasik ve 19’u (%31.7) gizli koroidal neovaskuler membran ozelliindeydi. Başlangıc ortalama en iyi gorme keskinlikleri (E‹GK) logMAR’a gore 0.84 }0.38 idi (0.30- 1.80). Tedavi sonrası E‹GK logMAR’a gore 0.78 }0.46 idi(0.10-1.60). Lezyon tiplerine gore ilk ve son gorme keskinlikleri arasında istatistiksel olarak anlamlı farklılık gorulmedi (p>0.05). Başlangıc E‹GK ile sonuc E‹GK arasında istatistiksel olarak pozitif yonde anlamlı ilişki bulundu. Sonuç: Yaşa balı makula dejenerasyonu (YBMD) zemininde gelişen subfoveal koroidal neovaskuler membranların verteporfin ile fotodinamik tedavisi gorme keskinliinin korunmasında etkili ve başarılı bir tedavi seceneidir.