Journals / Hacettepe Journal of Biology and Chemistry / 2012 / Cilt: 40 - Sayı: 2

Nepeta italica l. ve Nepeta cilicia boiss. apud bentham türlerinden elde edilen ekstraktların antioksidant enzimler üzerine etkileri

Effects of extracts obtained from Nepeta italica l. and Nepeta cilicia boiss. apud bentham on antioxidant enzymes

Pages
149–154
Publication Date
2022-10-17
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

In conclusion, it may suggest that the extracts are devoid of prooxidant properties, because lipid peroxidation hasn’t been observed, although the extracts have caused some changes in antioxidant enzymes.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:In the study, the effects of methanol and hexane extracts obtained from Nepeta italica L. and Nepeta cilicia Boiss. apud Bentham on antioxidant enzymes in healthy rat erythrocyte were studied.
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Key Findings & Data:The ethanol extract of N. cilicia caused a decrease in glucose-6-phosphate dehydrogenase (G6PD) activity and an increase in catalase (CAT) activity.
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Conclusion & Impact:In conclusion, it may suggest that the extracts are devoid of prooxidant properties, because lipid peroxidation hasn’t been observed, although the extracts have caused some changes in antioxidant enzymes.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

In the study, the effects of methanol and hexane extracts obtained from Nepeta italica L. and Nepeta cilicia Boiss. apud Bentham on antioxidant enzymes in healthy rat erythrocyte were studied. The ethanol extract of N. cilicia caused a decrease in glucose-6-phosphate dehydrogenase (G6PD) activity and an increase in catalase (CAT) activity. There wasn’t significant enzyme value in the group treated with the hexane extract of N. cilicia. However, the ethanol extract of N. italica caused a decrease in superoxide dismutase (SOD) and CAT activities. In group treated with hexane extract of N. italica, a significant decrease in SOD and CAT activities was observed, whereas a significant increase in G6PD activity was observed. Also, a statistically significant difference in MDA wasn’t found in all groups. In conclusion, it may suggest that the extracts are devoid of prooxidant properties, because lipid peroxidation hasn’t been observed, although the extracts have caused some changes in antioxidant enzymes.

Özet

Bu çalışmada, Nepeta italica L. and Nepeta cilicia Boiss. apud Bentham türlerinden elde edilen hekzan ve metanol ekstraktlarının sağlıklı rat eritrosit antioksidan enzimleri üzerine etkileri araştırılmıştır. N. cilicia etanol ekstraktı, glukoz-6-fosfat dehidrogenez (G6PD) aktivitesinde azalmaya, katalaz (CAT) aktivitesinde artışa neden olmuştur. N. cilicia hekzan ekstraktı uygulanan grupta, enzim değerlerinde anlamlı bir fark bulunmamıştır. Bununla birlikte, N. italica etanol ekstraktı, süperoksit dismutaz (SOD) ve CAT aktivitelerinde azalmaya neden olmuştur. N. italica hekzan ekstraktının uygulandığı grupta ise G6PD aktivitesinde artış gözlenirken, SOD ve CAT aktivitelerinde azalma gözlenmiştir. Tüm gruplarda, malondialdehid (MDA) seviyelerinde istatistiksel olarak anlamlı bir fark bulunmamıştır. Sonuç olarak, ekstraktların antioksidan enzimlerde bazı değişimlere neden olmasına karşın lipid peroksidasyonu gözlenmemiştir, bu nedenle bitki ekstraktlarının pro-oksidan bir özellik göstermediği söylenebilir.

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Cite This Article

GENÇ, H., YAZICI, S. Ö., KONAK, Ş., ÖZMEN, İ., ÖZDEMİR, F., BÜYÜKOĞLU, T. İ., ÖZÇELİK, H. (2022). Nepeta italica l. ve Nepeta cilicia boiss. apud bentham türlerinden elde edilen ekstraktların antioksidant enzimler üzerine etkileri. Hacettepe Journal of Biology and Chemistry, Cilt: 40 - Sayı: 2, 149–154. https://ajindex.com/articles/529211

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References (16)

  1. J.M. Mates, C. Perez-Gomes, I.N. De Castro, Antioxidant enzymes and human diseases. Clin. Biochem., 32 (1999) 595
  2. B. Halliwell, Biochemistry of oxidative stres, Biochem. Soc. Trans., 35 (2007) 1147
  3. H.C.L. Liang, H.G. Shertzer, D.W. Nebert, “Oxidative stress” responce in liver of an untreated newborn mouse having a 1.2-centimorgan deletion on chromosome, Biochem. Biophys. Res. Commun., 182 (1992) 1160
  4. T.P.A. Devasagayam, J.C. Tilak, K.K. Boloor, K.S. Sane, S.S. Ghaskadbi, R.D. Lele, Review: Free radicals and antioxidants in human health: Curr Stat Fut Prosp, JAPI 52 (2004) 794
  5. A. Alim, I. Goze, A. Çetin, A.D. Ataş, S. Akkus Çetinus, N. Vural, Chemical composition and in vitro antimicrobial and antioxidant activities of the essential oil of Nepeta nuda L. subsp. Albiflora (Boiss.) gams., AJMR, 3 (2009) 463
  6. S. Nagarajan, H.C. Jain, G.S. Aulakh, Indigenous plants used in the control of diabetes, Publication and Information Directorate CSI, New Delhi, 1987
  7. M.C. Sabu, R. Kuttan, Anti-diabetic activity of medicinal plants and its relationship with their antioxidant property, J. Ethnopharmacol, 81 (2002) 155
  8. M.J. Laughton, B. Halliwell, P.J. Evans, J.R.S. Hoult, Antioxidant and pro-oxidant actions of the plant phenolics quercetin, gossypol and myricetin, Biochem. Pharmacol., 38 (1989) 859
  9. G.C. Yen, H-Y. Chen, H-H. Peng, Antioxidant and pro-Oxidant effects of various tea extracts, J. Agric. Food Chem., 45 (1997) 30
  10. P.H. Davis, Flora of Turkey and the Aegean Islands, Edinburgh, Univ. Press.,1982
  11. K.H.C. Baser, N. Kirimer, M. Kurkcuoglu, B. Demirci, Essential oil of Nepeta species growing in Turkey, Chem. Nat. Comp., 36 (2000) 356
  12. G. Gkinis, O.Tzakou, D. Iliopoulou, V. Roussis, Chemical composition and biological activity of Nepeta parnassica oils and isolated nepetalactones. Z. Naturforsch. 58c (2003) 681
  13. S. Aydın, R. Beis, Y. Öztür, K.H. Başer, Nepetalactone: a new opioid analgesic from Nepeta caesarea Boiss., J. Pharm. Pharmacol., 50 (1998) 813
  14. N. Miceli, M.F. Taviano, D. Giuffrida, A. Trovato, O. Tzakou, E.M. Galati, Anti-inflammatory activity of extract and fractions from Nepeta sibthorpii Bentham., J. Ethnopharmacol, 97 (2005) 261
  15. A. Sonboli, P. Salehib, M. Yousefzadi, Antimicrobial activity and chemical composition of the essential oil of Nepeta crispa wild from Iran, Z, Naturforsch., 59c, (2004) 653
  16. M. Rabbani, S.E. Sajjadi, A. Mohammadi, Evaluation of the anxiolytic effect of Nepeta persic