SavedAdd your journal

Journals / Hacettepe Journal of Biology and Chemistry / 2016 / Cilt: 44 - Sayı: 4

Synthesis, Structural Characterization, and Water Solubility of a Novel Modified Poly(maleic anhydride-co-vinyl acetate)/ Acriflavine Conjugate

Yeni Modifiye Poli(maleik anhidrid-ko-vinil asetat)/Akriflavin Konjugatının Sentezi, Yapısal Karakterizasyonu ve Suda Çözünürlüğü

Gülderen Karakuş
Pages
549–558
Publication Date
2022-10-17
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The spectroscopic results confirmed that conjugated/modification reaction was successfully carried out by amidification reaction.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Novel functional poly(maleic anhydride-co-vinyl acetate)/acriflavine conjugate, MAVA/AF, was synthesized in two different ways that copolymer:drug ratio was designed as 1:1 and 1:2, respectively.
📊
Key Findings & Data:The purified copolymer, MAVA, was modified with an antiexternal fungal and anticancer active agent acriflavine (AF) at 60°C for 72 hours in dimethylformamide (DMF), using triethylamine (TEA) as the catalyst.
💡
Conclusion & Impact:The spectroscopic results confirmed that conjugated/modification reaction was successfully carried out by amidification reaction.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Novel functional poly(maleic anhydride-co-vinyl acetate)/acriflavine conjugate, MAVA/AF, was synthesized in two different ways that copolymer:drug ratio was designed as 1:1 and 1:2, respectively. Nontoxic polymeric drug carrier was prepared for conjugation reaction. The purified copolymer, MAVA, was modified with an antiexternal fungal and anticancer active agent acriflavine (AF) at 60°C for 72 hours in dimethylformamide (DMF), using triethylamine (TEA) as the catalyst. Structural characterizations were carried out by Fourier Transform Infrared (FTIR) and Nuclear Magnetic Resonance (1H-NMR). The spectroscopic results confirmed that conjugated/modification reaction was successfully carried out by amidification reaction.

Özet

Yeni fonksiyonel poli(maleik anhidrit-ko-vinil asetat)/Akriflavin konjugatı, MAVA/AF, iki farklı yolla kopolimer:ilaç oranı sırasıyla 1:1 ve 1:2 olacak şekilde sentezlendi. Konjugasyon tepkimesi için toksik olmayan polimerik ilaç taşıyıcı hazırlandı. Saflaştırılan kopolimer, MAVA, antikanser aktif akriflavin (AF) ajanı ile 60°C’da 72 saat dimetilformamid (DMF) içinde, trietilamin (TEA) katalizörlüğünde modifiye edildi. Yapısal karakterizasyon Fourier Transform Infrared (FTIR) ve Nükleer Magnetik Rezonans (1H-NMR) ile yapıldı. Spektroskopik analiz sonuçları konjugasyon/modifikasyon tepkimesinin başarılı bir şekilde amidleşme reaksiyonu ile olduğunu doğrulamaktadır.

🔖

Cite This Article

Karakuş, G. (2022). Synthesis, Structural Characterization, and Water Solubility of a Novel Modified Poly(maleic anhydride-co-vinyl acetate)/ Acriflavine Conjugate. Hacettepe Journal of Biology and Chemistry, Cilt: 44 - Sayı: 4, 549–558. https://ajindex.com/articles/529124

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (16)

  1. G. Vilara, J. Tulla-Puchea, F. Albericio, Polymers and Drug Delivery Systems, Curr. Drug. Deliv., 9 (2012) 1-28
  2. W.B. Liechty1, D.R. Kryscio1, B.V. Slaughter, N.A. Peppas, Polymers for Drug Delivery Systems, Annu. Rev. Chem. Biomol. Eng., 1 (2010) 149–173
  3. G.R. Saad, RE. Morsi, S.Z. Mohammady, M.Z. Elsabee, Dielectric relaxation of monoesters based poly(styrene-co-maleic anhydride) copolymer, J. Polym. Res., 15 (2008) 115-123
  4. O.G. Atıcı, A. Akar, R. Rahimian, Modification of poly(maleic anhydride-co- styrene) with hydroxyl containing compounds, Turk. J. Chem., 25 (2001) 259-266
  5. H. Patel, DA. Raval, D. Madamwar, S.R. Patel, Polymeric prodrug: Synthesis, release study and antimicrobial property of poly(styrene-co-maleic anhydride)-bound acriflavine, Angew. Makromol. Chem., 263 (1998) 25-30
  6. H.Y. Liu, K. Cao, Z. Yao, B.G. Li, GH. Hu, Variations of the glass-transition temperature in the imidization of poly(styrene-co-maleic anhydride), J. Appl. Polym. Sci., 104 (2007) 2418-2422
  7. I. Popescu, D.M. Suflet, I.M. Pelin, G.C. Chitanu, Biomedical applications of maleic anhydride copolymers, Rev. Roum. Chim., 56 (2011) 173-188
  8. R. Duncan, Polymer conjugates for tumour targeting and intracytoplasmic delivery. The EPR effect as a common gateway?, Research focus reviews, 2 (1999) 441-449
  9. K. Hoste, K.D. Winne, E. Schacht, Polymeric prodrugs, Int. J. Pharmaceut., 277 (2004) 119-131
  10. H. Ringsdorf, Structure and properties of pharmacologically active polymers, J. Polym. SCI., 51 (1975) 135-153
  11. K. Greish, T. Sawa, J. Fang, T. Akaika, H. Maeda, SMA-doxorubicin, a new polymeric micellar drug for effective targeting to solid tumors, J. Control. Release., 97 (2004) 219-230
  12. H. Maeda, SMANCS and polymer-conjugated macromolecular drugs: advantages in cancer chemotherapy, Adv. Drug. Deliv. Rev., 6 (1991) 181-202
  13. N. Doğan, Farmasötik Kimyaya Giriş, Nobel Tıp Kitabevleri, (2007) İstanbul, 126s
  14. H.H. Eldaroti, AS. Gadir, S.M. Refat, A. Adam, Charge Transfer Complexes of the Donor Acriflavine and the Acceptors Quinol, Picric acid, TCNQ and DDQ: Synthesis, Spectroscopic Characterizations and Antimicrobial Studies. Int. J. Electrochem. Sci., 8 (2013) 5774-5800
  15. G. Karakus, H.B. Zengin, Z. Akin Polat, A.F. Yenidunya and S. Aydin, Cytotoxicity of three maleic anhydride copolymers and common solvents used for polymer solvation, Polym. Bull., 70 (2013) 1591-1612
  16. G. Karakus, Z. Akin Polat, A.F. Yenidunya, HB. Zengin, C.B. Karakus,