Journals / Hacettepe Journal of Biology and Chemistry / 2020 / Cilt: 48 - Sayı: 5

Electrospun Nanofibers for Wound Dressing and Tissue Engineering Applications

Yara Örtüsü ve Doku Mühendisliği Uygulamaları için Elektro-eğirme ile Üretilen Nanolifler

Pages
459–481
Publication Date
2022-10-17
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Further the concerns for future direction regard to clinical phase transfer has been discussed.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Electrospinning has received tremendous attention in the fabrication of nanofibrous scaffolds over recent years andemployed in different biomedical applications because of their biomimetic nature.
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Key Findings & Data:Especially, the electrospunnanofibers exhibit several beneficial features including natural extracellular matrix (ECM), interconnected pores, largesurface area, ease of functionalization and mechanical performance that holds huge importance in influencing the celladhesion, differentiation and proliferation behaviour.
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Conclusion & Impact:Further the concerns for future direction regard to clinical phase transfer has been discussed.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Electrospinning has received tremendous attention in the fabrication of nanofibrous scaffolds over recent years andemployed in different biomedical applications because of their biomimetic nature. Especially, the electrospunnanofibers exhibit several beneficial features including natural extracellular matrix (ECM), interconnected pores, largesurface area, ease of functionalization and mechanical performance that holds huge importance in influencing the celladhesion, differentiation and proliferation behaviour. To date, acknowledging the wide range of beneficial features, theelectrospun nanofibers have been used in wound dressing and tissue engineering applications. This review summarizesvarious efforts have been made in these areas with several representative examples indicating use of various materials andapproaches. Further the concerns for future direction regard to clinical phase transfer has been discussed.

Özet

Elektro-eğirme yöntemi ile üretilen nanolifler, son yıllarda nanofibröz yapı iskelelerinin geliştirilmesinde büyük ilgi gördü ve biyomimetik yapıları nedeniyle farklı biyomedikal uygulamalarda kullanıldı. Özellikle, elektro-eğirme yöntemi ile üretilen nanolifler doğal hücre dışı matris (ECM), birbirine bağlı gözenekler, geniş yüzey alanı, işlevselleştirme kolaylığı ve hücre adezyonunu, farklılaşmasını ve proliferasyon davranışını etkilemede büyük önem taşıyan mekanik performans dahil olmak üzere birçok faydalı özellik sergiler. Bugüne kadar, çok çeşitli yararlı özellikleri kabul eden bu nanolifler, yara örtüsü ve doku mühendisliği uygulamalarında kullanılmıştır. Bu derlemede, çeşitli malzemelerin ve yaklaşımların kullanımını gösteren birkaç temsili örneklerle bu alanlarda çeşitli çabaların yapıldığını özetlemektedir. Ayrıca, klinik faz transferine ilişkin gelecekteki yön endişeleri tartışılmıştır.

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Cite This Article

BALUSAMY, B., SENTHAMİZHAN, A., UYAR, T. (2022). Electrospun Nanofibers for Wound Dressing and Tissue Engineering Applications. Hacettepe Journal of Biology and Chemistry, Cilt: 48 - Sayı: 5, 459–481. https://ajindex.com/articles/528977

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