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Journals / Hacettepe Dişhekimliği Fakültesi Derg.(. Clinical Dentistry and Research) / 2006 / Cilt: 30 - Sayı: 3

The effect of ibuprofen treatment on superoxide dismutase activity in gingiva and gingival crevicular fluid in patients with chronicperiodontitis

Kronik periodontitisli hastalarda sistemik ibuprofen tedavisinin dişeti ve dişeti oluğu sıvısı superoksit dismutaz enzim aktivitesine etkisi

Ferda Alev AKALIN
Nurten RENDA
Esra TOKLU
Pages
91–101
Publication Date
2022-10-17
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

Results: Gingival SOD activity was significantly higher in patients than controls, while significantly reduced after ibuprofen (p0.05).

📌 3 Key Takeaways

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Objective & Hypothesis:Introduction: Antioxidant enzyme superoxide dismutase (SOD), protects against reactive oxygen species (ROS).
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Key Findings & Data:Material and Methods: Twenty-six CP-patients, 18 periodontally-healthy controls were studied.
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Conclusion & Impact:Results: Gingival SOD activity was significantly higher in patients than controls, while significantly reduced after ibuprofen (p0.05).
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Introduction: Antioxidant enzyme superoxide dismutase (SOD), protects against reactive oxygen species (ROS). It is known that non-steroidal antiinflammatory drugs scavenge ROS. Purpose:To evaluate the effect of ibuprofen on gingival and gingival crevicular fluid (GCF) SOD activity in chronic periodontitis (CP). Material and Methods: Twenty-six CP-patients, 18 periodontally-healthy controls were studied. Patients presented teeth which required periodontal surgery in two quadrants of maxilla (site A, site B). Baseline GCF was collected from sites A and B and gingiva was collected from site A, during surgery. Samplings were repeated 1 week after 6-week- ibuprofen treatment (gingiva, GCF) and postoperative 1, 3 months (GCF) (site B). Controls’ gingivae were obtained after orthodontic tooth extraction. SOD activities were spectrophotometrically determined. Results: Gingival SOD activity was significantly higher in patients than controls, while significantly reduced after ibuprofen (p0.05).

Özet

Giriş: Superoksit dismutaz (SOD) hücreyi reaktif oksijen türlerinden (ROS) koruyan antioksidan bir enzimdir. Non steroid anti-inflamatuar ilaçların ROS’ni baskıladığı belirtilmektedir. Amaç: Kronik periodontitiste (KP) ibuprofen tedavisinin dişeti ve dişeti oluğu sıvısı (DOS) SOD aktivitesine etkisinin araştırılmasıdır. Gereçler ve Yöntem: Yirmialtı KP’li-hasta ve 18 periodontal-sağlıklı-kontrolde üst çenede sağ ve sol kuadrantlarda (A, B bölgeleri) çalışıldı. A ve B bölgelerinden periodontal cerrahi gereken dişlerden başlangıç DOS örnekleri, A bölgesinden cerrahi ile dişeti örnekleri alındı. Altı-haftalık ibuprofen tedavisinden 1 hafta sonra B bölgesinden DOS ve dişeti, cerrahiden 1, 3 ay sonra B bölgesinden DOS örnekleri toplandı. Kontrollerde dişetleri ortodontik diş çekiminden sonra soket çevresinden alındı. SOD aktivitesi spektrofotometrik olarak saptandı. Bulgular: Dişeti SOD aktivitesi hastalarda kontrollerden yüksek iken (p

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Cite This Article

AKALIN, F. A., RENDA, N., TOKLU, E. (2022). The effect of ibuprofen treatment on superoxide dismutase activity in gingiva and gingival crevicular fluid in patients with chronicperiodontitis. Hacettepe Dişhekimliği Fakültesi Derg.(. Clinical Dentistry and Research), Cilt: 30 - Sayı: 3, 91–101. https://ajindex.com/articles/528481

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