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Journals / Gaziantep Tıp Dergisi / 2013 / Cilt: 19 - Sayı: 3

Replication of coronavirus Recep BAYRAKTAR, İbrahim BOZGEYİK,

Coronavirüslerin replikasyonları

Mustafa ULAŞLI
Pages
141–148
Publication Date
2022-10-18
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

This review described replication, transcription, and assembly of CoVs.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Coronaviruses (CoVs) are a diverse family of viruses that interact at multiple levels with components of host cells taking this advantage of some of the cellular machineries for replication and proliferation.
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Key Findings & Data:The challenge now is to incorporate advance techniques in the investigative efforts done to understand further the biology of CoVs.
💡
Conclusion & Impact:This review described replication, transcription, and assembly of CoVs.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Coronaviruses (CoVs) are a diverse family of viruses that interact at multiple levels with components of host cells taking this advantage of some of the cellular machineries for replication and proliferation. A lot is known about the molecular biology of CoVs but more information needs to be learned because no effective treatments against these viruses are available. The challenge now is to incorporate advance techniques in the investigative efforts done to understand further the biology of CoVs. In terms of molecular biology, mouse hepatitis virus (MHV) is the best-studied CoVs, and it is consequently considered a model system for the family of Coronaviridae. This review described replication, transcription, and assembly of CoVs.

Özet

Coronavirüsler (CoVs) çok çeşitlilik gösteren bir virüs ailesidir. CoVlar konak hücrelerle birçok aşamada etkileşime geçerler ve konak hücrenin değişik mekanizmalarını kullanarak enfeksiyonlarını ve replikasyonlarını gerçekleştirirler. CoVların moleküler biyolojisiyle ilgili olarak birçok şey bilinmektedir. Ancak CoVların moleküler biyolojisini daha iyi anlamak için daha çok bilgiye ihtiyaç vardır ve CoVlara karşı geliştirilmiş herhangi etkili bir ilaç tedavisi bulunmamaktadır. CoVların moleküler biyolojisini daha iyi anlama adına son yıllarda yapılan araştırmalarda birçok teknik ve yöntem kullanılmıştır. Moleküler biyolojik araştırmalar açısından fare hepatit virüsü en çok çalışılan CoVlardır ve Coronaviridae ailesi üyelerini araştırmak için iyi bir model sistemdir. Bu derleme CoVlerin replikasyonunu, transkripsiyonunu ve tekrar bir araya getirilmesini anlatmaktadır.

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Cite This Article

ULAŞLI, M. (2022). Replication of coronavirus Recep BAYRAKTAR, İbrahim BOZGEYİK,. Gaziantep Tıp Dergisi, Cilt: 19 - Sayı: 3, 141–148. https://ajindex.com/articles/518847

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References (14)

  1. de Haan CA, de Wit M, Kuo L, Montalto-Morrison C, Haagmans BL, Weiss SR, et al. The glycosylation status of the murine hepatitis coronavirus M protein affects the interferogenic capacity of the virus in vitro and its ability to replicate in the liver but not the brain. Virology 2003;312(2):395-406
  2. Lai MM, Cavanagh D. The molecular biology of coronaviruses. Adv Virus Res 1997;48:1-100
  3. Pasternak AO, Spaan WJ, Snijder EJ. Nidovirus transcription: how to make sense? J Gen Virol 2006;87(Pt 6):1403-21
  4. Gorbalenya AE, Enjuanes L, Ziebuhr J, Snijder EJ. Nidovirales: evolving the largest RNA virus genome. Virus Res 2006;117(1):17-37. 5. de Haan CA, Rottier PJ. Molecular interactions in the assembly of coronaviruses. Adv Virus Res 2005;64:165-230
  5. Perlman S, Netland J. Coronaviruses post-SARS: update on replication and pathogenesis. Nat Rev Microbiol 2009;7(6):439- 50
  6. Sawicki SG, Sawicki DL, Siddell SG. A contemporary view of coronavirus transcription. J Virol 2007;81(1):20-9
  7. Horzinek MC. Comparative aspects of togaviruses. J Gen Virol 1973;20(Suppl):87-103
  8. Weiss M, Horzinek MC. The proposed family Toroviridae: agents of enteric infections. Brief review. Arch Virol 1987;92(1- 2):1-15. 10. von Brunn A, Teepe C, Simpson JC, Pepperkok R, Friedel CC, Zimmer R, et al. Analysis of intraviral protein-protein interactions of the SARS coronavirus ORFeome. PLoS One 2007;2(5):e459
  9. Wijegoonawardane PK, Cowley JA, Phan T, Hodgson RA, Nielsen L, Kiatpathomchai W, et al. Genetic diversity in the yellow head nidovirus complex. Virology 2008;380(2):213-25
  10. Brian DA, Baric RS. Coronavirus genome structure and replication. Curr Top MicrobiolImmunol 2005;287:1-30
  11. Ziebuhr J, Snijder EJ, Gorbalenya AE. Virus-encoded proteinases and proteolytic processing in the Nidovirales. J Gen Virol 2000;81(Pt 4):853-79
  12. Snijder EJ, Ederveen J, Spaan WJ, Weiss M, Horzinek MC. Characterization of Berne virus genomic and messenger RNAs. J Gen Virol 1988;69(Pt 9):2135-44
  13. Snijder EJ, den Boon JA, Horzinek MC, Spaan WJ. Comparison of the genome organization of toro- and coronaviruses: evidence for two nonhomologous RNA recombination events during Berne virus evolution. Virology 1991;180(1):448-52
  14. Gonzalez JM, Gomez-Puertas P, Cavanagh D, Gorbalenya AE, Enjuanes L.A comparative sequence analysis to revise the current taxonomy of the family Coronaviridae. Arch Virol 2003;148(11):2207-35. 17. den Boon JA, Snijder EJ, Chirnside ED, de Vries AA, Horzinek