Association of rs11209032 and rs1004819 Polymorphisms in Interleukin-23 Receptor Gene With Ankylosing Spondylitis

There was no significant difference between AS patients and controls in terms of genotype frequencies of IL-23R gene rs11209032 and rs1004819 polymorphisms.Conclusion: No association was found between AS and IL23R rs11209032 and rs1004819 polymorphisms in this Turkish AS cohort

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives: This study aims to investigate the distribution of human leukocyte antigen B27 (HLA-B27) alleles (+/-) and interleukin-23 receptor (IL-23R) gene rs11209032 and rs1004819 polymorphisms among ankylosing spondylitis (AS) patients in a Turkish cohort.Patients and methods: The study sample comprised 106 AS patients (89 males, 18 females; mean age 38.9±10 years; range 19 to 65 years) and 82 healthy controls (70 males, 12 females; mean age 32.15±7.07 years; range 19 to 51 years).

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Key Findings & Data:Distribution of HLA-B27 alleles (+)/(-) in AS patients were observed by reverse hybridization technique.

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Conclusion & Impact:There was no significant difference between AS patients and controls in terms of genotype frequencies of IL-23R gene rs11209032 and rs1004819 polymorphisms.Conclusion: No association was found between AS and IL23R rs11209032 and rs1004819 polymorphisms in this Turkish AS cohort

🔬Design:Research Article

📍Scope:Comprehensive Sample

⚙️Variables:Domain Parameters

Abstract

Objectives: This study aims to investigate the distribution of human leukocyte antigen B27 (HLA-B27) alleles (+/-) and interleukin-23 receptor (IL-23R) gene rs11209032 and rs1004819 polymorphisms among ankylosing spondylitis (AS) patients in a Turkish cohort.Patients and methods: The study sample comprised 106 AS patients (89 males, 18 females; mean age 38.9±10 years; range 19 to 65 years) and 82 healthy controls (70 males, 12 females; mean age 32.15±7.07 years; range 19 to 51 years). Distribution of HLA-B27 alleles (+)/(-) in AS patients were observed by reverse hybridization technique. Genotyping of IL-23R rs11209032 and rs1004819 polymorphisms of AS patients and healthy controls were performed by real time polymerase chain reaction.Results: Of the AS patients, 69 (65.1%) were HLA-B27 positive. Distribution of rs11209032 genotype frequencies in AS group were 31.1% for GG, 50.9% for GA, and 17.9% for AA; while in control group, it was 34.1% for GG, 53.7% for GA, and 12.2% for AA. Distribution of rs1004819 genotype frequencies in AS group were 30.2% for CC, 52.8% for CT, and 17.0% for TT; while in control group, it was 42.7% for CC, 46.3% for CT, and 11.0% for TT. There was no significant difference between AS patients and controls in terms of genotype frequencies of IL-23R gene rs11209032 and rs1004819 polymorphisms.Conclusion: No association was found between AS and IL23R rs11209032 and rs1004819 polymorphisms in this Turkish AS cohort

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Cite This Article

ERDOĞAN, M. Ö., ÇANKAYA, T. Ş., ULAŞLI, A. M., YILDIZ, S. H., TERZİ, E. S. A., ÇAVDAR, T., DÜNDAR, Ü., SOLAK, M. (2016). Association of rs11209032 and rs1004819 Polymorphisms in Interleukin-23 Receptor Gene With Ankylosing Spondylitis. art, Cilt: 31 - Sayı: 3, 201–207. https://ajindex.com/articles/351734

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References (11)

Gouveia EB, Elmann D, Morales MS. Ankylosing spondylitis and uveitis: overview. Rev Bras Reumatol 2012;52:742-56.
Onen F, Akar S, Birlik M, Sari I, Khan MA, Gurler O, et al. Prevalence of ankylosing spondylitis and related spondyloarthritides in an urban area of Izmir, Turkey. J Rheumatol 2008;35:305-9.
Braun J, Sieper J. Building consensus on nomenclature and disease classification for ankylosing spondylitis: results and discussion of a questionnaire prepared for the International Workshop on New Treatment Strategies in Ankylosing Spondylitis, Berlin, Germany, 18-19 January 2002. Ann Rheum Dis 2002;61:61-7.
Brown M, Wordsworth P. Predisposing factors to spondyloarthropathies. Curr Opin Rheumatol 1997;9:308-14. Maksymowych WP. Spondyloartropathies: Etiology and pathogenesis of ankylosing spondylitis. In: Hochberg M, Silman AJ, Smolen JS, Weinblatt ME, Weisman MH, editors. Rheumatol. 3rd ed. Philadelphia: Elsevier Limited; 2003. p. 1183-92.
OMIM (2015). Available from: http://www.omim.org/ entry/607562. [Accessed 6 June 2015]
Parham C, Chirica M, Timans J, Vaisberg E, Travis M, Cheung J, et al. A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R. J Immunol 2002;168:5699-708.
Duerr RH, Taylor KD, Brant SR, Rioux JD, Silverberg MS, Daly MJ, et al. A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Science 2006;314:1461-3.
Burton PR, Clayton DG, Cardon LR, Craddock N, Deloukas P, Duncanson A, et al. Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. Nat Genet 2007;39:1329-37.
Wang X, Huang J, Lin Z, Liao Z, Li C, Wei Q, et al. Single-nucleotide polymorphisms and expression of IL23R in Chinese ankylosing spondylitis patients. Rheumatol Int 2010;30:955-9.
Qian BP, Jiang J, Ji ML, Wang B, Yu Y, Qiu Y. Lack of associations between two previously identified susceptible single nucleotide polymorphisms of interleukin-23 receptor gene and ankylosing spondylitis: a replication study in a Chinese Han population. BMC Musculoskelet Disord 2013;14:190. Rahman P. Genetics of ankylosing spondylitis: an update. Curr Rheumatol Rep 2007;9:383-9. Brown MA. Breakthroughs in genetic studies of ankylosing spondylitis. Rheumatology (Oxford) 2008;47:132-7. Reveille JD. The genetic basis of ankylosing spondylitis. Curr Opin Rheumatol 2006;18:332-41.
Zhang G, Luo J, Bruckel J, Weisman MA, Schumacher HR, Khan MA, et al. Genetic studies i