Journals / Fırat Üniversitesi Sağlık Bilimleri Dergisi / 2005 / Cilt: 19 - Sayı: 2

Repair of experimentally induced osteochondral defects of dog knee joint with cancellous autogreft

Köpek diz ekleminde deneysel oluşturulan osteokondral defektlerin otojen kansellöz gref ile odanılması

Pages
107–113
Publication Date
2022-10-17
DOI
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As a result, it was suggested that cancellous bone grefts could be used as regeneration accelerator for repair of large osteochondral defect. '

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Objective & Hypothesis:Repair of Experimentally Induced Osteochondral Defects of Dog Knee Joint With Cancellous Autogreft In this study the effectiveness of the application of cancellous autogreft in the repair of the osteochondral defects created experimentally in the knee joint of the dogs was evaluated.
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Key Findings & Data:In the study,. 12 mature dogs between 20-35 kg of weight were used.
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Conclusion & Impact:As a result, it was suggested that cancellous bone grefts could be used as regeneration accelerator for repair of large osteochondral defect. '
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Repair of Experimentally Induced Osteochondral Defects of Dog Knee Joint With Cancellous Autogreft In this study the effectiveness of the application of cancellous autogreft in the repair of the osteochondral defects created experimentally in the knee joint of the dogs was evaluated. In the study,. 12 mature dogs between 20-35 kg of weight were used. After anesthesia was maintained by Rompun followed by Ketalar, genu joint was exposed through lateral para patellar approach. A defect with 8 mm diameter and 10 mm deep was created on femoral sulcus by sliding patella aside. The same operation was repeated in both legs. While the defects in the right leg was filled by autogenic cancellous greft taken from metaphysial region of tibia the defect in the left leg was left empty for the control consideration. The small lameness was seen in all cases' ten days after the operation, dissappeared afterward in the histopatological examination while regeneration and reparation formations were seen in the bone and cartilage components in the control and greft applied groups in the second month, focal fibrocartilagenous formation was observed to be started in the greft applied group in the 4th month. In 10 to 12th month, the defects were filled up completely with fibrous cartilage. In the control group, however, a small fibrocartilagenous formation was detected only in the 8 th month. In the 10 th and 12 th month, the defect surface was seen to have been covered by fibrocartilagenous structure but femoral sulcus remained unfilled in the control group level. As a result, it was suggested that cancellous bone grefts could be used as regeneration accelerator for repair of large osteochondral defect. '

Özet

Bu çalışmada köpek diz ekleminde deneysel oluşturulan osteokondral defektlerin onarımında kansellöz otogref uygulamalarının etkinliği araştırılmıştır. Çalışmada vücut ağırlıkları 20-35 kg arasında değişen 12 adet erişkin köpek kullanıldı. Hayvanlar rompun+ketalar anestezisine alındıktan sonra, genu eklemine lateral parapatellar yaklaşımla ulaşıldı. Patella yana doğru kaydırılarak femoral sulkus üzerinde 8 mm çapında ve 10 mm derinliğinde bir defekt oluşturuldu. Aynı işlem diğer bacakta da tekrarlandı. Sağ bacaktaki defetler tibiamn metafizer bölgesinden alınan otojen kansellöz grene doldurulurken, sol bacaktaki defektler boş bırakılarak kontrol grubunu oluşturdu. Tüm olgularda ilk 10 gün görülen hafif dereceli topallık daha sonraki incelemelerde tamamen ortadan kalktı. Histopatolojik incelemelerde ikinci ayda kontrol ve gref uygulanan gruplarda kemik ve kıkırdak kompanentlerinde rejenerasyon ve reperasyona yönelik yapılanmalar dikkati çekerken, dördüncü ayda gref uygulanan grupta fokal fibrokartilaginöz yapıların gelişmeye başladığı görüldü. On ve on ikinci aylarda gref uygulanan grupta defektin tamamen fıbröz kıkırdakla dolduğu tespit edildi. Kontrol grubunda ise ancak sekizinci ayda hafif bir fibrokartilaginöz yapının varlığı tespit edildi. On ve on ikinci aylarda kontrol grubunda yüzeyin fibrokartilaginöz yapıyla kaplandığı, ancak defektin trochlear oluk seviyesine kadar dolmadığı görüldü. Sonuç olarak, geniş osteokondral defektlerin onarımında, rejenerasyonu hızlandırıcı kansellöz kemik greflerin bu amaçla kullanımının uygun olacağı kanısına varıldı.

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Cite This Article

YAMAN, M., SAĞLIYAN, A., GÜNAY, C., ÜNSALDI, E. (2022). Repair of experimentally induced osteochondral defects of dog knee joint with cancellous autogreft. Fırat Üniversitesi Sağlık Bilimleri Dergisi, Cilt: 19 - Sayı: 2, 107–113. https://ajindex.com/articles/514221

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References (1)

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