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Journals / Eurasian Journal of Medical Investigation / 2021 / Cilt: 5 - Sayı: 2

The Value of Preoperative Amino Terminal Pro BrainNatriuretic Peptide Levels in Showing Post-Operative KidneyFunctions in Patients Having Undergone Coronary ArteryBypass Grafting Surgery

Mete GÜRSOY
Ercan SERVET
Pages
201–206
Publication Date
2022-10-12
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

We need prospectivestudies with high numbers of patients in this aspect.

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives: Natriuretic peptides are proteins secreted by myocardium as a response to the volume and/or pressureload; especially B type Brain Natriuretic Peptide (BNP) has started to be used for the last two decades in issues such asmortality, morbidity after coronary artery surgery and estimation of major adverse cardiac issues, particularly heart fail ure.
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Key Findings & Data:Methods: In this study, 40 patients (33 males/7 females) whose ejection fraction was between 30% and 50% wereprospectively examined.
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Conclusion & Impact:We need prospectivestudies with high numbers of patients in this aspect.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objectives: Natriuretic peptides are proteins secreted by myocardium as a response to the volume and/or pressureload; especially B type Brain Natriuretic Peptide (BNP) has started to be used for the last two decades in issues such asmortality, morbidity after coronary artery surgery and estimation of major adverse cardiac issues, particularly heart fail ure. The purpose of this study is to research on the activity of BNP in predicting the risk of kidney failure after coronaryartery bypass grafting. Methods: In this study, 40 patients (33 males/7 females) whose ejection fraction was between 30% and 50% wereprospectively examined. These patients were among ones having undergone coronary artery bypass grafting by usinga cardiopulmonary machine. Blood was venously taken from patients preoperatively, on the second postoperative dayand in the sixth postoperative month in order to examine BUN (blood urea nitrogen), creatinine and plasma NT-proBNP. Results: It was observed that values of NT- proBNP examined preoperatively were negatively correlated with bothcreatinine clearances before the operation (CrCl pre-op) (p=0.031) and the values of creatinine clearance examined onthe second postoperative day (CrCl 2. day) (p=0.014).Conclusion: On the basis of our results, we are of the opinion that the preoperative BNP value might be a leadingparameter in renal monitoring in the early phase after the operation and in the treatment plan. We need prospectivestudies with high numbers of patients in this aspect.

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Cite This Article

GÜRSOY, M., SERVET, E. (2022). The Value of Preoperative Amino Terminal Pro BrainNatriuretic Peptide Levels in Showing Post-Operative KidneyFunctions in Patients Having Undergone Coronary ArteryBypass Grafting Surgery. Eurasian Journal of Medical Investigation, Cilt: 5 - Sayı: 2, 201–206. https://ajindex.com/articles/508561

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References (15)

  1. Magnussen C, Blankenberg S. Biomarkers for heart failure: small molecules with high clinical relevance. J Intern Med 2018;283:530–43
  2. Maisel AS, Duran JM, Wettersten N. Natriuretic peptides in heart failure: atrial and B-type natriuretic peptides. Heart Fail Clin 2018;14:13–25
  3. Vuolteenaho O, Ala-Kopsala M, Ruskoaho H. BNP as a biomarker in heart disease. Adv Clin Chem 2005;40:1–36
  4. Bastin AJ, Ostermann M, Slack AJ, Diller GP, Finney SJ, Evans TW. Acute kidney injury af-ter cardiac surgery according to Risk/Injury/Failure/Loss/End-stage, Acute Kidney Injury Network, and Kidney Disease: Improving Global Outcomes classifications. J Crit Care 2013;28:389–96
  5. Englberger L, Suri RM, Li Z, Casey ET, Daly RC, Dearani JA, et al. Clinical accuracy of RIFLE and Acute Kidney Injury Network (AKIN) criteria for acute kidney injury in patients undergoing cardiac surgery. Crit Care 2011;15:R16
  6. Krzych ŁJ, Szurlej D, Kołodziej T, Machej L, Węglarzy A, Błach A, et al. Diagnostic accuracy of pre-operative NT-proBNP level in predicting short-term outcomes in coronary surgery: a pilot study. Kardiol Pol 2011;69:1121–7
  7. Kato TS, Machida Y, Kuwaki K, Yamamoto T, Amano A. Factors associated with postopera-tive requirement of renal replacement therapy following off-pump coronary bypass surgery. Heart Vessels 2017;32:134–42
  8. Wang Y, Bellomo R. Cardiac surgery-associated acute kidney injury: risk factors, pathophysi-ology and treatment. Nat Rev Nephrol 2017;13:697–711
  9. Cheung BM, Kumana CR. Natriuretic peptides--relevance in cardiovascular disease. JAMA 1998;280:1983–4
  10. Stein BC, Levin RI. Natriuretic peptides: physiology, therapeutic potential, and risk stratifica-tion in ischemic heart disease. Am Heart J 1998;135:914–23
  11. Yoshimura M, Yasue H, Okumura K, Ogawa H, Jougasaki M, Mukoyama M, et al. Different secretion patterns of atrial natriuretic peptide and brain natriuretic peptide in patients with con-gestive heart failure. Circulation 1993;87:464–9
  12. Ruskoaho H. Cardiac hormones as diagnostic tools in heart failure. Endocr Rev 2003;24:341–56
  13. Munagala VK, Burnett JC Jr, Redfield MM. The natriuretic peptides in cardiovascular medici-ne. Curr Probl Cardiol 2004;29:707–69
  14. Levin ER, Gardner DG, Samson WK. Natriuretic peptides. N Engl J Med 1998;339:321–8
  15. Hutfless R, Kazanegra R, Madani M, Bhalla MA, Tulua-Tata A, Chen A, et al. Utility of B-type natriuretic peptide in predicting postoperative complications and outcomes in pat