Journals / Erciyes Tıp Dergisi / 2007 / Cilt: 29 - Sayı: 1

Renal functions in children with juvenile idiopatic arthritis

Juvenil idiopatik artritli çocuklarda böbrek fonksiyonları

Pages
25–30
Publication Date
2022-10-17
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

However, this result may be linked to our limitations such as limited number of patients and the relatively short duration of the follow-up period.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Purpose: In this study, we aimed to evaluate renal tubular and glomerular functions in Juvenile idiopathic arthritis.Material and methods: Twenty children (12 male, 8 female) with juvenile idiopathic arthritis (JIA) and 10 children (4 boys, 6 girls) as controls were included in the study.
📊
Key Findings & Data:The following renal laboratory tests were performed in both patients and control group: serum biochemical parameters, electrolytes in 24-h urine, microalbumin in 24-h urine, venous pH, HCO3- and serum osmalility.
💡
Conclusion & Impact:However, this result may be linked to our limitations such as limited number of patients and the relatively short duration of the follow-up period.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Purpose: In this study, we aimed to evaluate renal tubular and glomerular functions in Juvenile idiopathic arthritis.Material and methods: Twenty children (12 male, 8 female) with juvenile idiopathic arthritis (JIA) and 10 children (4 boys, 6 girls) as controls were included in the study. The following renal laboratory tests were performed in both patients and control group: serum biochemical parameters, electrolytes in 24-h urine, microalbumin in 24-h urine, venous pH, HCO3- and serum osmalility. The second morning urine specimens were obtained from the patients and control group in order to determine urinary Cr levels, complete urinalysis, phosphorus, N-acetyle-b-glucosaminidase (NAG), Renitol binding protein (RBP), renal failure index (RFI), reabsorbsion of tubular phosphorus (TRP), fractional sodium excretion (FeNa), and urinary osmolality. Renal ultrasonography (USG) was undergone to determine nephrocalcinosis in both patient and control group.Results: The mean follow-up duration of the patients was 21 months (range:1-107) There were no statistically significant differences with regard to glomerular and tubular functions between the patient and control groups. Renal biopsy was performed on two patients and revealed mesengioproliferative glomerulonephritis in one patient, and amyloidosis in the other. Conclusion: Our results could not determine that children with JIA tend to have renal disorders. However, this result may be linked to our limitations such as limited number of patients and the relatively short duration of the follow-up period.

Özet

Amaç: Bu çalışma juvenil idiopatik artritli çocuklarda böbrek tubuler ve glomeruler fonksiyonların değerlendirilmesi amacı ile planlanmıştır.Materyal ve metod: Juvenil idiopatik artritli 20 çocuk (12 erkek, 8 kız) ve kontrol grubu olarak sağlıklı 10 çocuk (4 erkek, 6 kız) çalışmaya alındı. Hasta ve kontrol grubunda serum biyokimyasal parametreler, 24 saatlik idrarda elektrolitler ve mikroalbümin, kan gazı ve serum osmalaritesi çalışıldı. Spot idrarda tam idrar analizi, Cr, P, N-asetil-b-glukozaminidaze(NAG), retinol bağlayıcı protein (RBP) ve osmolarite ölçüldü. Nefrokalsinozis varlığını araştırmak için ultrasonografi yapıldı.Bulgular: Hastalarımızın ortalama takip süresi 21(1-107) ay idi. Renal tubüler ve glomeruler fonksiyonlar bakımından hasta ve kontrol grubu arasında istatistiksel fark saptanmadı. İki hastaya idrar bulguları nedeni ile biyopsi yapıldı. Bir olguda renal amiloidoz, diğer olguda mezengioproliferatif glomerulonefrit saptandı.Sonuç: Çalışma sonuçlarımız juvenil idiopatik artritli çocuklarda böbrek etkilenmesini gösterememiştir. Bu sonuç hasta sayısının azlığı ve kısmi olarak kısa izlem süreleri ile ilişkili olabilir.

🔖

Cite This Article

DÜŞÜNSEL, R., GÜNDÜZ, Z., POYRAZOĞLU, M., ANARAT, R., DURSUN, İ., GÜRGÖZE, M. K., KOÇ, A. (2022). Renal functions in children with juvenile idiopatic arthritis. Erciyes Tıp Dergisi, Cilt: 29 - Sayı: 1, 25–30. https://ajindex.com/articles/502697

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (9)

  1. Langman CB. Nephrolithiasis, In: Rudolph CD, Rudolph AM, Hostetter MK, Lister G, Sýegel NJ, editors. Rudolph’s Pediatrics. (21st ed.) New York; The Mc Graw-Hill Companies 2002, p 1715-1718
  2. Petty RE, Cassidy J. Juvenile rheumatoid arthritis. In: Cassidy JT, Petty RE, editors. Textbook of Pediatric Rheumotology. Saunders. Philadelphia 2001, p 218-321
  3. Goksel AK, Sever L, Kasapçopur O, Caliskan S, Balci H, Arisoy N. Albuminuria and tubular markers in juvenile idiopathic arthritis. Pediatr Nephrol 2005;20:154-158
  4. Malleson PN, Lockitch G, Mackinnon M, Mahy M, Petty RE. Renal disease in chronic arthritis of childhood. Arthritis Rheum 1990; 33:1560-1566 5. Kibar Y, Dayanç M (2004). Pediatrik ürolityazis, In: Dayanç M editor. Güncel Çocuk Ürolojisi. Ankara, Atlas Kitapçılık 2004, s 357-368
  5. Dursun İ, Gündüz Z, Gürgöze MK ve ark. Mezengioproliferatif glomerulonefritli sistemik idiopatik artrit olgusu. Türk Nefroloji Diyaliz ve Transplantasyon Dergisi 2005; 14: 148-150 7. Boers M. Renal disorders in rheumatoid arthritis. Semin Arthritis Rheum 1990; 20:57-68 8. David J. Amyloidosis in juvenile chronic arthritis. Clin Exp Rheumatol1991; 9:73-78 9. von Biljon G. Reversible renal failure associated with ibuprofen in a child: a case report. S Afr Med J 1989;76:34-35
  6. Cantagrel A, Fournie B, Pourrat J, Conte JJ, Fournie A. [Renal microscopic hematuria in rheumatoid polyarthritis, French]. Rev Interne 1991; 12:31-2, 35-6
  7. Helin HJ, Korpela MM, Mustonen JT, Pasternack AI. Renal biopsy findings and clinicopatholojic correlations in rheumatoid arthritis. Arthritis Rheum 1995; 38: 242-247
  8. Kasapçopur O, Sever L, Taşdan Y, Çalışkan S, Arısoy N. Hypercalciuria and hematuria in juvenile idiopathic arthritis. J Rheumatol 1998; 25:993-996
  9. Adu D, Berisa F, Howie AJ et al. Glomerulonephritis in rheumatoid arthritis. Br J Rheumotol 1993; 32:1008-1011 14. Burkle PA, Tonnesmann E, Franz HE, Federlin [K. Mesangiocapillary glomerulonephritis and rheumatoid arthritis. A case with diagnostic and therapeutic questions, German]. Immun Infect 1976; 4:79-83 15. Dohi K, Shiiki H, Kawano T, Kanauchi M, Ishikawa H, Watanabe T. Membranous nephropathy with crescents in rheumatoid arthritis: a case report. Jpn J Nephrol 1991;33:81-85 16. Dhib M, Prieur AM, Courville S et al. Crecentic glomerulonephritis in juvenile chronic arthritis. J Rheumatol 1996; 23: 1636-1640 17. Foster BJ, Duffy CM, Sharma AK. Systemic juvenile rheumatoid arthritis complicated by two differen