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Journals / Erciyes Tıp Dergisi / 2008 / Cilt: 30 - Sayı: 4

Meme kanserinde CA 15-3, CEA ve CA 125 lenfovasküler yayılım için belirleyici midir?

Are CA 15-3, CEA and CA 125 predictors for lymphatic and vascular spread in breast cancer?

Can ATALAY
Pages
218–224
Publication Date
2022-10-17
DOI
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Besides, serum CA 125 levels increased in patients with extracapsular tumor extension in axillary lymph nodes (p=0.007) and with vascular and lymphatic invasion by tumor cells (p=0.015).Conclusion: This study has shown that CA 15-3, CEA, and CA 125 could be helpful in predicting well-known prognostic factors such as axillary metastases and tumor size as well as extracapsular tumor extension and lymphovascular invasion in breast cancer.

📌 3 Key Takeaways

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Objective & Hypothesis:Purpose: Tumor markers can be used to predict the prognostic factors in patients with breast cancer and, in this study, correlation between CA 15-3, CEA, and CA 125 and the prognostic factors in breast cancer is evaluated.
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Key Findings & Data:Material and Methods: Patients treated for breast cancer between 2002 - 2004 were prospectively included in the study.
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Conclusion & Impact:Besides, serum CA 125 levels increased in patients with extracapsular tumor extension in axillary lymph nodes (p=0.007) and with vascular and lymphatic invasion by tumor cells (p=0.015).Conclusion: This study has shown that CA 15-3, CEA, and CA 125 could be helpful in predicting well-known prognostic factors such as axillary metastases and tumor size as well as extracapsular tumor extension and lymphovascular invasion in breast cancer.
🔬Design:Research Article
📍Scope:2002 - 2004 Verileri
⚙️Variables:Domain Parameters

Abstract

Purpose: Tumor markers can be used to predict the prognostic factors in patients with breast cancer and, in this study, correlation between CA 15-3, CEA, and CA 125 and the prognostic factors in breast cancer is evaluated. Material and Methods: Patients treated for breast cancer between 2002 - 2004 were prospectively included in the study. Serum levels of CA 15-3, CEA, and CA 125 were evaluated in patient groups formed according to various clinical and histopathologic prognostic factors.Results: 233 patients with breast cancer were included in the study. Higher serum levels of CA 15-3 and CEA were detected in patients with larger tumors (p=0.01 for CA 15-3; p=0.005 for CEA) and serum CA 15-3 and CA 125 levels increased in patients with axillary involvement (p=0.033 for CA 15-3; p=0.036 for CA 125). Besides, serum CA 125 levels increased in patients with extracapsular tumor extension in axillary lymph nodes (p=0.007) and with vascular and lymphatic invasion by tumor cells (p=0.015).Conclusion: This study has shown that CA 15-3, CEA, and CA 125 could be helpful in predicting well-known prognostic factors such as axillary metastases and tumor size as well as extracapsular tumor extension and lymphovascular invasion in breast cancer.

Özet

Amaç: Tümör belirteçleri meme kanserli hastalarda prognostik faktörleri tahmin etmede kullanılabilir. Bu çalışmada CA 15-3, CEA, ve CA 125 ile meme kanserinde bilinen prognostik faktörler arasındaki ilişkinin değerlendirilmesi amaçlandı. Gereç ve Yöntemler: 2002 - 2004 yılları arasında meme kanseri tanısıyla tedavi edilen hastalar prospektif olarak çalışmaya alındı. Klinik ve histopatolojik prognostik faktörlere göre oluşturulan gruplardaki hastaların serum CA 15-3, CEA, ve CA 125 düzeyleri karşılaştırıldı.Bulgular: Meme kanseri olan 233 hasta çalışmaya alındı. Tümör boyutu daha fazla olan hastalarda serum CA 15-3 ve CEA düzeyleri daha yüksek bulundu (p=0.01 CA 15-3 için; p=0.005 CEA için). Aksillada lenf bezi tutulumu olan hastalarda serum CA 15-3 ve CA 125 düzeylerinde artış saptandı (p=0.033 CA 15-3 için; p=0.036 CA 125 için). Ayrıca, serum CA 125 düzeyinde aksiller lenf bezlerinde ekstrakapsüler yayılım olan (p=0.007) ve lenfovasküler invazyon saptanan (p=0.015) hastalarda artış görüldü.Sonuç: Bu çalışmada, serum CA 15-3, CEA, ve CA 125 düzeylerinin meme kanserinde aksilla metastazı, tümör boyutu, aksiller lenf bezlerinde ekstrakapsüler yayılım ve lenfovasküler invazyon gibi iyi bilinen prognostik faktörleri tahmin etmede yararlı olabileceği gösterildi.

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Cite This Article

ATALAY, C. (2022). Meme kanserinde CA 15-3, CEA ve CA 125 lenfovasküler yayılım için belirleyici midir?. Erciyes Tıp Dergisi, Cilt: 30 - Sayı: 4, 218–224. https://ajindex.com/articles/502662

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