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Journals / Erciyes Tıp Dergisi / 2010 / Cilt: 32 - Sayı: 1

In-vitro activity of carbapenem/sulbactam combination against acinetobacter baumannii strains

Karbapenem-sefaperazon/sulbaktam kombinasyonlarının acinetobacter baumannii suşları üzerine in vitro aktivitesi

Fatma Mutlu SARIGÜZEL
Barış SÜMERKAN
Gökhan METAN
Pages
15–18
Publication Date
2022-10-17
DOI
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⚡ TL;DR(Too Long; Didn't Read)

No antagonism was detected with any combination.Conclusion: According to our in vitro study results, carbapenem-cefoperazone/ sulbactam combination can be an alternative for the treatment of infections caused by multidrug-resistant A. baumannii.

📌 3 Key Takeaways

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Objective & Hypothesis:Purpose: Carbapenems and sulbactam are often the drug of choice for the treatment of infections due to multidrug-resistant Acinetobacter baumannii.
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Key Findings & Data:The present study aimed to evaluate the in vitro synergistic activity between carbapenem and sulbactam against A. baumannii isolated from blood cultures of patients.Material and Method: The 100 A. baumannii strains isolated from blood culture specimens of patients hospitalized at Erciyes University Medical Faculty Gevher Nesibe Hospitals between February 2007 and March 2008, were included in this study.
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Conclusion & Impact:No antagonism was detected with any combination.Conclusion: According to our in vitro study results, carbapenem-cefoperazone/ sulbactam combination can be an alternative for the treatment of infections caused by multidrug-resistant A. baumannii.
🔬Design:Research Article
📍Scope:2007 Verileri
⚙️Variables:Domain Parameters

Abstract

Purpose: Carbapenems and sulbactam are often the drug of choice for the treatment of infections due to multidrug-resistant Acinetobacter baumannii. The present study aimed to evaluate the in vitro synergistic activity between carbapenem and sulbactam against A. baumannii isolated from blood cultures of patients.Material and Method: The 100 A. baumannii strains isolated from blood culture specimens of patients hospitalized at Erciyes University Medical Faculty Gevher Nesibe Hospitals between February 2007 and March 2008, were included in this study. The in vitro synergistic activities of carbapenem-cefoperazone/ sulbactam combination on 100 A. baumannii strains were studied by E-test method.Results: With the combination of imipenem- cefoperazone/ sulbactam and meropenem- cefoperazone/ sulbactam on 43% and 49% of the strains respectively, synergistic activity was detected. No antagonism was detected with any combination.Conclusion: According to our in vitro study results, carbapenem-cefoperazone/ sulbactam combination can be an alternative for the treatment of infections caused by multidrug-resistant A. baumannii.

Özet

Amaç: Çoğul ilaç dirençli Acinetobacter baumannii enfeksiyonlarının tedavisinde sulbaktam ve karbapenemler sık tercih edilen ilaçlardır. Bu çalışmada, karbapenem-sefoperazon/ sulbaktam kombinasyonlarının, kan kültürlerinden izole edilen A. baumannii izolatları üzerine in vitro sinerjistik etkisine bakılması amaçlanmıştır.Gereç ve Yöntem: Şubat 2007- Mart 2008 ayları arasında Erciyes Üniversitesi Gevher Nesibe Araştırma ve Uygulama Hastanesi kliniklerindeki hastalardan gönderilen kan kültürü örneklerden izole edilen 100 A. baumannii suşu çalışmaya alındı. Karbapenem-sefoperazon/sulbaktam kombinasyonlarının izolatlar üzerine in vitro sinerjistik etkisine E-test yöntemi ile bakılmıştır.Bulgular: İmipenem- sefoperazon/sulbaktam ve meropenem-sefoperazon/sulbaktam kombinasyonları için sırası ile %43 ile %49 oranlarında sinerjistik aktiviteye sahip olduğu saptandı. Bu kombinasyonlarda antagonistik aktivite bulunmamıştır.Sonuç: İn vitro çalışma sonuçlarımıza göre, karbapenem- sulbaktam kombinasyonunun çoğul ilaç dirençli Acinetobacter baumannii enfeksiyonlarının tedavisinde bir alternatif olabileceği görülmüştür.

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Cite This Article

SARIGÜZEL, F. M., SÜMERKAN, B., METAN, G. (2022). In-vitro activity of carbapenem/sulbactam combination against acinetobacter baumannii strains. Erciyes Tıp Dergisi, Cilt: 32 - Sayı: 1, 15–18. https://ajindex.com/articles/502545

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