Comparison of the Effectiveness of Rapamycin and Gabapentin Treatment in Rats with Induced Sciatic Nerve Injury

Objective & Hypothesis:Objective: The purpose of this study was to compare the therapeutic effects of gabapentin (GBP) and different doses of rapamycin (RAPA) in an induced sciatic nerve (SN)-injury rat model.

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Key Findings & Data:Materials and Methods: The study consisted of 7 groups: Control, Sham, High-dose rapamycin (RAPA-H), Low-dose rapamycin (RAPA-L), GBP, DMSO and DMSO+nerve injury (DMSO+NI).

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Conclusion & Impact:Results: Significant differences (p

🔬Design:Modeling & Simulation

📍Scope:Comprehensive Sample

⚙️Variables:Domain Parameters

Abstract

Objective: The purpose of this study was to compare the therapeutic effects of gabapentin (GBP) and different doses of rapamycin (RAPA) in an induced sciatic nerve (SN)-injury rat model. Materials and Methods: The study consisted of 7 groups: Control, Sham, High-dose rapamycin (RAPA-H), Low-dose rapamycin (RAPA-L), GBP, DMSO and DMSO+nerve injury (DMSO+NI). Medical treatment was administered intraperitoneally for 30 days after the induction of SN injury. Results: Significant differences (p

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Cite This Article

YAY, A. H., CANPOLAT, M., KUMANDAŞ, S., ÇOLPAK, H. A., CANPOLAT, D. G., ÖNDER, G. Ö., YETKİN, M. F., ZARARSIZ, G. E. (2022). Comparison of the Effectiveness of Rapamycin and Gabapentin Treatment in Rats with Induced Sciatic Nerve Injury. Erciyes Medical Journal, Cilt: 44 - Sayı: 1, 56–62. https://ajindex.com/articles/502169

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