Comparison of the Effectiveness of Rapamycin and Gabapentin Treatment in Rats with Induced Sciatic Nerve Injury

Amaç & Hipotez:Objective: The purpose of this study was to compare the therapeutic effects of gabapentin (GBP) and different doses of rapamycin (RAPA) in an induced sciatic nerve (SN)-injury rat model.

📊

Temel Bulgular & Veri:Materials and Methods: The study consisted of 7 groups: Control, Sham, High-dose rapamycin (RAPA-H), Low-dose rapamycin (RAPA-L), GBP, DMSO and DMSO+nerve injury (DMSO+NI).

💡

Sonuç & Katkı:Results: Significant differences (p

🔬Tür:Modelleme & Sayısal Simülasyon

📍Kapsam:Genişletilmiş Akademik Örneklem

⚙️Değişkenler:Alan Parametreleri

Abstract

Objective: The purpose of this study was to compare the therapeutic effects of gabapentin (GBP) and different doses of rapamycin (RAPA) in an induced sciatic nerve (SN)-injury rat model. Materials and Methods: The study consisted of 7 groups: Control, Sham, High-dose rapamycin (RAPA-H), Low-dose rapamycin (RAPA-L), GBP, DMSO and DMSO+nerve injury (DMSO+NI). Medical treatment was administered intraperitoneally for 30 days after the induction of SN injury. Results: Significant differences (p

🔖

Bu Makaleye Atıf Yap

YAY, A. H., CANPOLAT, M., KUMANDAŞ, S., ÇOLPAK, H. A., CANPOLAT, D. G., ÖNDER, G. Ö., YETKİN, M. F., ZARARSIZ, G. E. (2022). Comparison of the Effectiveness of Rapamycin and Gabapentin Treatment in Rats with Induced Sciatic Nerve Injury. Erciyes Medical Journal, Cilt: 44 - Sayı: 1, 56–62. https://ajindex.com/articles/502169

📄 Tam Metin PDF Okuyucu

Yeni Sekmede Aç ↗

↗Yeni Sekme

📄

PDF görüntüleyici hazırlanıyor...

Kaynakça (15)

Modrak M, Talukder MAH, Gurgenashvili K, Noble M, Elfar JC. Peripheral nerve injury and myelination: Potential therapeutic strategies. J Neurosci Res 2020; 98(5): 780–95
Canpolat DG, Soylu E, Dogruel F, Kütük N, Ugur F. Comparison of the analgesic effects of pulse radiofrequency and cryoablation in rabbits with mental nerve neuropathic pain. Niger J Clin Pract 2018; 21(5): 585–90
Smith RV, Havens JR, Walsh SL. Gabapentin misuse, abuse and diversion: a systematic review. Addiction 2016; 111(7): 1160–74
Huang Z, Wang W, Ma J, Li B, Chen J, Yang H, et al. mTOR signaling pathway differently regulates central and peripheral axon regeneration. Acta Biochim Biophys Sin (Shanghai) 2017; 49(8): 689–95
Özcan Ö, Dikmen M. mTOR inhibitors in the treatment of cancer. Marmara Pharm J 2015; 19: 290–7
Küçüköner M, Işıkdoğan A. mTOR signaling pathway and mTOR inhibitors in the treatment of cancer. Dicle Med J 2013; 40(1): 156–60
Rangaraju S, Verrier JD, Madorsky I, Nicks J, Dunn WA Jr, Notterpek L. Rapamycin activates autophagy and improves myelination in explant cultures from neuropathic mice. J Neurosci 2010; 30(34): 11388–97
Nicks J, Lee S, Harris A, Falk DJ, Todd AG, Arredondo K, et al. Rapamycin improves peripheral nerve myelination while it fails to benefit neuromuscular performance in neuropathic mice. Neurobiol Dis 2014; 70: 224–36
Seltzer Z, Dubner R, Shir Y. A novel behavioral model of neuropathic pain disorders produced in rats by partial sciatic nerve injury. Pain. 1990; 43(2): 205–18
O’Connor AB. Neuropathic pain: quality-of-life impact, costs and cost effectiveness of therapy. Pharmacoeconomics 2009; 27(2): 95–112
Alles SRA, Smith PA. Etiology and pharmacology of neuropathic pain. Pharmacol Rev 2018; 70(2): 315–47
Kim KH, Seo HJ, Abdi S, Huh B. All about pain pharmacology: what pain physicians should know. Korean J Pain 2020; 33(2): 108–20
Ozbek Z, Aydin HE, Kocman AE, Ozkara E, Sahin E, Bektur E, et al. Neuroprotective effect of genistein in peripheral nerve injury. Turk Neurosurg 2017; 27(5): 816–22
Câmara CC, Araújo CV, de Sousa KKO, Brito GAC, Vale ML, Raposo RDS, et al. Gabapentin attenuates neuropathic pain and improves nerve myelination after chronic sciatic constriction in rats. Neurosci Lett 2015; 607: 52–8
Machado JA, Ghizoni MF, Bertelli J, Teske GC, Teske GC, Martins DF, et al. Stretch-induced nerve injury: a proposed technique for the study of nerve regeneration and evaluation of th