Epilepsy Surgery in Pediatric Patients: A Single-Center Experience

Key Findings & Data:Our aim is to share demographic data, surgical outcome, possible surgical complications, and factors that affect surgical outcome in pediatric patients with drug-resistant epilepsy who were operated in our clinic.

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Conclusion & Impact:The best surgical outcome was achieved in patients with resective surgeries (p

🔬Design:Research Article

📍Scope:2005 Verileri

⚙️Variables:Domain Parameters

Abstract

Objectives: Epilepsy surgery is one of the treatment options in pediatric patients with drug-resistant epilepsy. Our aim is to share demographic data, surgical outcome, possible surgical complications, and factors that affect surgical outcome in pediatric patients with drug-resistant epilepsy who were operated in our clinic. Methods: In this retrospective study, 85 patients who were operated in Acibadem Hospital Pediatric Epilepsy Surgery Clinic between years 2005 and 2017 were included. We investigated the influence of sex, age at seizure onset, side and frequency of seizures, time to surgery, type of epilepsy surgery, and histopathology on pediatric epilepsy surgery outcome. Surgical outcome was assessed by Engel classification system. Statistical analysis was performed with SPSS 20.0 software. Results: There were 56 male (66%) and 29 female (34%) participants. Median of the age of seizure onset is 2 years (1 day–15 years). Median of age at operation is 6.2 years (3 months–16 years). Median of the duration of seizure until surgery is 3.2 years (3 months–15.5 years). Median follow-up is 5.6 years (3 months–13.5 years). There were permanent motor neurological deficits in 3 patients (3.5%). The best surgical outcome was achieved in patients with resective surgeries (p

Özet

Amaç: İlaca dirençli epilepsi hastalığında epilepsi cerrahisi uygun olgularda etkili tedavi yöntemlerinden biridir. Bu çalışmadaki amacımız kliniğimizde epilepsi cerrahisi uygulanan çocukluk çağı ilaca dirençli epilepsi hastalarının demografik veri, ameliyat başarısı, olası cerrahi komplikasyonlar ve ameliyat başarısına etki eden faktörleri araştırmak ve çocukluk çağı epilepsi cerrahisi klinik tecrübemizi paylaşmaktır. Gereç ve Yöntem: Bu geriye dönük çalışmaya kliniğimizde 2005–2017 yılları arasında ilaca dirençli epilepsi nedeni ile epilepsi cerrahisi yapılan 85 çocuk hasta dahil edilmiştir. Yaş, cinsiyet, nöbetin başlama yaşı, tarafı, sıklığı, nöbet başlangıcı ile ameliyat arasındaki zaman, epilepsi cerrahisi çeşidi ve histopatoloji değişkenleri ile cerrahi başarının arasındaki ilişki araştırılmıştır. Cerrahi başarı Engel sınıflaması ile ölçeklendirilmiştir. Veriler SPSS 20.0 programı ile analiz edilmiştir. Bulgular: Araştırmaya dahi edilen hastalarının 56’sı (%66) erkek, 29’u (%34) kadındır. Nöbet başlama medyan yaşı ikidir (1 gün–15 yıl). Ameliyat zamanındaki medyan yaş 6.2’ dir (3 ay–16 yıl). Nöbet başlangıcı ile cerrahi arasında geçen medyan yıl 3.2’dir (3 ay–15.5 yıl). Medyan takip süresi 5.6 yıldır (3 ay–13.5 yıl). Hastaların üçünde (%3.5) kalıcı motor kayıp gelişmiştir. En yüksek cerrahi başarı rezektif cerrahi yapılan hastalarda izlenmiştir (p

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Cite This Article

ÖZEK, M. M., TANRIKULU, B., IŞIK, U. (2022). Epilepsy Surgery in Pediatric Patients: A Single-Center Experience. Epilepsi, Cilt: 25 - Sayı: 1, 27–34. https://ajindex.com/articles/501653

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References (10)

Kubova H, Lukasiuk K, Pitkänen A. New insight on the mechanisms of epileptogenesis in the developing brain. Adv Tech Stand Neurosurg 2012;39:3–44. Kotsopoulos IA, van Merode T, Kessels FG, de Krom MC, Knottnerus JA. Systematic review and meta-analysis of incidence studies of epilepsy and unprovoked seizures. Epilepsia 2002;43(11):1402–9.
Tonini C, Beghi E, Berg AT, Bogliun G, Giordano L, Newton RW, et al. Predictors of epilepsy surgery outcome: A meta-analysis. Epilepsy Res 2004;62(1):75–87.
Berg AT, Mathern GW, Bronen RA, Fulbright RK, DiMario F, Testa FM, et al. Frequency, prognosis and surgical treatment of structural abnormalities seen with magnetic resonance imaging in childhood epilepsy. Brain 2009;132(10):2785–97.
Kwan P, Arzimanoglou A, Berg AT, Brodie MJ, Allen Hauser W, Mathern G, et al. Definition of drug resistant epilepsy: Consensus proposal by the ad hoc task force of the ILAE commission on therapeutic strategies. Epilepsia 2010;51(6):1069–77.
Engel JJ, Van Ness P, Rasmussen TB, Ojemann LM. Outcome with respect to epileptic seizures. In: Engel JJ, editor. Surgical treatment of th epilepsies. New York: Raven Press; 1993. p. 609– 22. Ito M, Sato K, Ohnuki A, Uto A. Sturge-weber disease: Operative indications and surgical results. Brain Dev 1990;12(5):473–7.
Duchowny M, Jayakar P, Resnick T, Harvey AS, Alvarez L, Dean P, et al. Epilepsy surgery in the first three years of life. Epilepsia 1998;39(7):737–43. Naegele J. Epilepsy and the plastic mind. Epilepsy Curr 2009;9(6):166–9. Besag FM. Childhood epilepsy in relation to mental handicap and behavioural disorders. J Child Psychol Psychiatry 2002;43(1):103–31. Covanis A. Epileptic encephalopathies (including severe epilepsy syndromes). Epilepsia 2012;53(4):114–26.
Cross JH, Jayakar P, Nordli D, Delalande O, Duchowny M, Wieser HG, et al. Proposed criteria for referral and evaluation of children for epilepsy surgery: Recommendations of the subcommission for pediatric epilepsy surgery. Epilepsia 2006;47(6):952–9.
Ryvlin P, Cross JH, Rheims S. Epilepsy surgery in children and adults. Lancet Neurol 2014;13(11):1114–26.
Bien CG, Raabe AL, Schramm J, Becker A, Urbach H, Elger CE, et al. Trends in presurgical evaluation and surgical treatment of epilepsy at one centre from 1988-2009. J Neurol Neurosurg Psychiatry 2013;84(1):54–61.
Cossu M, Lo Russo G, Francione S, Mai R, Nobili L, Sartori I, et al. Epilepsy surgery in children: Results and predictors of outcome on seizures. Epilepsia 2008;49(1):65–72. Ber