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Journals / Epilepsi / 2020 / Cilt: 26 - Sayı: 1

Epileptic Activity in a Patient with Serum Anti-GAD Antibody-positive Limbic Encephalitis

Serum Anti-GAD Antikoru Pozitif Limbik Ensefalitli Hastada Epileptik Aktivite

Zeynep ÖZÖZEN AYAS
Dilcan KOTAN
Journal
Epilepsi
Pages
45–48
Publication Date
2022-10-17
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

GADAb is considered to play an important role in the prognosis of LE and the other neurological syndromes and should be investigated further.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Limbic encephalopathy (LE) is an entity, which may present with memory loss, seizure, psychiatric symptoms and is usually accompanied byneuro-radiology imaging findings.
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Key Findings & Data:In this article, we report a 38-year-old woman presenting with seizure and diagnosed with limbic encephalitiswho had magnetic resonance imaging and electroencephalograhy findings accompanied by serum GAD-ab positivity was reported.
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Conclusion & Impact:GADAb is considered to play an important role in the prognosis of LE and the other neurological syndromes and should be investigated further.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Limbic encephalopathy (LE) is an entity, which may present with memory loss, seizure, psychiatric symptoms and is usually accompanied byneuro-radiology imaging findings. In recent years, antibody tests that can be studied in detail have gained importance as markers. Glutamicacid decarboxylase antibody (GAD-Ab) has been reported to be mainly responsible for non-paraneoplastic syndromes. GAD-Ab positivity ispredominantly seen in young adult females and temporal lobe epilepsy. Patients with GAD-Ab positive have been reported to respond wellor partial to immunotherapy. In this article, we report a 38-year-old woman presenting with seizure and diagnosed with limbic encephalitiswho had magnetic resonance imaging and electroencephalograhy findings accompanied by serum GAD-ab positivity was reported. GADAb is considered to play an important role in the prognosis of LE and the other neurological syndromes and should be investigated further.

Özet

Limbik ensefalit (LE) bellek kaybı, nöbet, psikiyatrik bulgular ile ortaya çıkabilen çoğunlukla nöro-radyolojik görüntüleme bulgularıyla desteklenebilen bir antitedir. Son yıllarda ayrıntılı çalışılabilen antikor testleri belirteç olarak önem kazanmıştır. Glutamik asit dekarboksilaz antikorunun (GAD-ab) çoğunlukla non-paraneoplastik sendromlardan sorumlu olduğu bildirilmiştir. GAD-ab pozitifliği daha çok genç erişkin kadın hastalarda ve temporal lob epilepsisinde baskın olarak görülmektedir. GAD-Ab olan hastaların immünoterapiye tam veya kısmi yanıt verdiği bildirilmiştir. Bu yazıda, nöbet ile başvuran, manyetik rezonans görüntüleme ve elektoensefalografi bulgularına serum GAD-ab pozitifliğinin eşlik ettiği LE tanısı alan 38 yaşında kadın olguyu sunduk. GAD-ab’nun LE ve diğer nörolojik sendromlarda patogenezde ve prognozda rol oynayabileceği düşünülmektedir.

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Cite This Article

AYAS, Z. Ö., KOTAN, D. (2022). Epileptic Activity in a Patient with Serum Anti-GAD Antibody-positive Limbic Encephalitis. Epilepsi, Cilt: 26 - Sayı: 1, 45–48. https://ajindex.com/articles/501648

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