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Journals / Epilepsi / 2021 / Cilt: 27 - Sayı: 4

Expression of Lung IL-1β and IL-6 in Pentylenetetrazol-Kindling Model Epilepsy

Enes AKYUZ
Nihal INANDIKLIOGLU
Betul KOKLU
Seliha SAHIN
Naciyenur GULERYUZ
Journal
Epilepsi
Pages
205–211
Publication Date
2022-10-17
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The significance of our findings will be supported by future studies on pro-inflammatory and anti-inflammatory responses in the lung.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objectives: Cytokines are thought to be involved in the pathogenesis of many neurological diseases such as epilepsy.
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Key Findings & Data:It is predicted that ınterleukin (IL)-1β and IL-6 levels in brain tissue are effective in the initiation and maintenance of epileptic seizures.
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Conclusion & Impact:The significance of our findings will be supported by future studies on pro-inflammatory and anti-inflammatory responses in the lung.
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objectives: Cytokines are thought to be involved in the pathogenesis of many neurological diseases such as epilepsy. It is predicted that ınterleukin (IL)-1β and IL-6 levels in brain tissue are effective in the initiation and maintenance of epileptic seizures. However, there is no study addressing the inflammatory process in the lung in epileptic conditions. It was aimed to contribute to the mechanism of respiratory pathologies accompanying epilepsy in this study. Methods: The chemical pentylenetetrazol (PTZ) has been used to develop epileptic seizures in rats. To examine the effect of seizures on the formation of inflammation in the lung, the expression levels of IL-1β and IL-6 were measured by real-time polymerase chain reaction. Results: We found that the expression levels of IL-6 and IL-1β in the lung tissue of rats in the animal model of epilepsy induced by PTZ increased significantly. In addition, we found that both IL-6 and IL-1β mRNA expression increased at a higher rate in epileptic females than males. Conclusion: This is the first study evaluating the IL-1β and IL-6 expression levels in the lung. Our results support the existence of an inflammatory state in epileptic patients. The significance of our findings will be supported by future studies on pro-inflammatory and anti-inflammatory responses in the lung.

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Cite This Article

AKYUZ, E., INANDIKLIOGLU, N., KOKLU, B., SAHIN, S., GULERYUZ, N. (2022). Expression of Lung IL-1β and IL-6 in Pentylenetetrazol-Kindling Model Epilepsy. Epilepsi, Cilt: 27 - Sayı: 4, 205–211. https://ajindex.com/articles/501613

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References (16)

  1. Thijs RD, Surges R, O’Brien TJ, Sander JW. Epilepsy in adults. Lancet 2019;393(10172):689–701
  2. Manolis TA, Manolis AA, Melita H, Manolis AS. Sudden unexpected death in epilepsy: The neuro-cardio-respiratory connection. Seizure 2019;64:65–73
  3. Devinsky O. Effects of seizures on autonomic and cardiovascular function. Epilepsy Curr 2004;4(2):43–6
  4. Stewart M, Silverman JB, Sundaram K, Kollmar R. Causes and effects contributing to sudden death in epilepsy and the rationale for prevention and intervention. Front Neurol 2020;11:765
  5. Rana A, Musto AE. The role of inflammation in the development of epilepsy. J Neuroinflammation 2018;15(1):144
  6. Shimada T, Takemiya T, Sugiura H, Yamagata K. Role of inflammatory mediators in the pathogenesis of epilepsy. Mediators Inflamm 2014;2014:901902
  7. Dinarello CA. Historical insights into cytokines. Eur J Immunol 2007;37(Suppl 1):34–45
  8. Alyu F, Dikmen M. Inflammatory aspects of epileptogenesis: Contribution of molecular inflammatory mechanisms. Acta Neuropsychiatr 2016;29(1):1–16
  9. Scorza CA, Marques MJ, da Silva SG, Naffah-Mazzacoratti MD, Scorza FA, Cavalheiro EA. Status epilepticus does not induce acute brain inflammatory response in the Amazon rodent Proechimys, an animal model resistant to epileptogenesis. Neurosci Lett 2018;668:169–73
  10. Shi LM, Chen RJ, Zhang H, Jiang CM, Gong J. Cerebrospinal fluid neuron specific enolase, interleukin-1β and erythropoietin concentrations in children after seizures. Child Nerv Syst 2017;33(5):805–11
  11. Vezzani A, Conti M, De Luigi A, Ravizza T, Moneta D, Marchesi F, et al. Interleukin-1beta immunoreactivity and microglia are enhanced in the rat hippocampus by focal kainate application: Functional evidence for enhancement of electrographic seizures. J Neurosci 1999;19(12):5054–65
  12. Gruol DL. IL-6 regulation of synaptic function in the CNS. Neuropharmacology 2015;96(Pt A):42–54
  13. Lehtimäki KA, Keränen T, Huhtala H, Hurme M, Ollikainen J, Honkaniemi J, et al. Regulation of IL-6 system in cerebrospinal fluid and serum compartments by seizures: The effect of seizure type and duration. J Neuroimmunol 2004;152(1–2):121–5
  14. Lehtimäki KA, Peltola J, Koskikallio E, Keränen T, Honkaniemi J. Expression of cytokines and cytokine receptors in the rat brain after kainic acid-induced seizures. Brain Res Mol Brain Res 2003;110(2):253–60
  15. Li G, Bauer S, Nowak M, Norwood B, Björn T, Rosenow F, et al. Cytokines and epilepsy. Seizure 2011;20(3):249–56
  16. Zhu X, Shen