Journals / Ege Klinikleri Tıp Dergisi / 2020 / Cilt: 58 - Sayı: 1

The Possible Effect Of Residence Area And Vitamin D Levels On Progression Of Multiple Sclerosis

Yaşanılan Bölge Ve Vitamin D Seviyelerinin Multiple Skleroz Progresyonuna Olası Etkisi

Pages
1–6
Publication Date
2022-10-11
DOI
—
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

Our results suggested that when age at first attack, the frequency of attacks, number of involved clinical systems, MRI involvement classification and EDSS scores were compared between groups according to vitamin D levels and the latitude of residence there were no statistically differences between groups (p>0,05).Conclusion: It was determined in our study that vitamin D levels do not have an effect on disease EDSS scores, the frequency of attacks, MRI involvement and number of involved clinical systems.

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: Multiple sclerosis (MS) is a chronic, inflammatory disease which affects mostly young population.
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Key Findings & Data:In this study we aimed to evaluate the course of MS according to their latitude of residence and vitamin D levels in our territory.Methods: A total of 48 MS patients had been included.
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Conclusion & Impact:Our results suggested that when age at first attack, the frequency of attacks, number of involved clinical systems, MRI involvement classification and EDSS scores were compared between groups according to vitamin D levels and the latitude of residence there were no statistically differences between groups (p>0,05).Conclusion: It was determined in our study that vitamin D levels do not have an effect on disease EDSS scores, the frequency of attacks, MRI involvement and number of involved clinical systems.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Aim: Multiple sclerosis (MS) is a chronic, inflammatory disease which affects mostly young population. Living close to the Equator that received steeper angles of sunlight and higher vitamin D levels is related with lower prevalence of MS and slower progression. In this study we aimed to evaluate the course of MS according to their latitude of residence and vitamin D levels in our territory.Methods: A total of 48 MS patients had been included. Birthplace of the patients and the territories where patients grew up had been questioned, and the patients were separated into two groups after determining the latitude of these areas, separated into three groups according to their vitamin D levels (very low level, low level, normal level). The patient’s age at first attack, the frequency of attacks, clinical system involvement, and involved areas in magnetic resonance imaging (MRI) have been documented. Expanded Disability Status Scale (EDSS) was used for the evaluation of disability. These variables were compared between latitude and vitamin D level groups.Results: The mean vitamin D level was 20.57±22.01(3-125) ng/ml. Our results suggested that when age at first attack, the frequency of attacks, number of involved clinical systems, MRI involvement classification and EDSS scores were compared between groups according to vitamin D levels and the latitude of residence there were no statistically differences between groups (p>0,05).Conclusion: It was determined in our study that vitamin D levels do not have an effect on disease EDSS scores, the frequency of attacks, MRI involvement and number of involved clinical systems.

Özet

Amaç: Multipl skleroz (MS) daha çok genç nüfusu etkileyen kronik, inflamatuar bir hastalıktır. Güneş ışınlarının dik gelmesi ve D vitamini seviyelerinin yüksek olması nedeniyle ekvatora yakın bölgelerde yaşamak MS prevalansını ve progresyonunu azaltır. Bu çalışmada yaşanılan enlemin ve D vitamini seviyelerinin MS hastalığının seyrine etkisini araştırmayı amaçladık. Yöntem: Totalde 48 hasta dahil edildi. Hastaların doğup büyüdükleri yer sorgulandı ve bu bölgelerin enlemleri belirlendikten sonra hastalar iki gruba ayrıldı, D vitamini seviyelerine göre hastalar üç gruba ayrıldı (çok düşük seviye, düşük seviye, normal seviye). Hastaların ilk atak yaşları, atak sıklığı, tutulan klinik sistem ve manyetik rezonans görüntülemede (MRG) tutulan bölgeler kaydedildi. Engelliliklerinin değerlendirilmesi için Genişletilmiş Özürlülük Durumu Ölçeği (EDSS) kullanıldı. Bu değişkenler ile enlem ve D vitamini düzeyi grupları karşılaştırıldı. Bulgular: Vitamin D düzeyi ortalaması 20.57±22.01(3-125) ng/ml idi. Bizim bulgularımızda ilk atak yaşı, atak sıklığı, tutulan klinik sistem sayısı, MRG de tutulan bölgeler ve EDSS skoru ile D vitamini düzeyleri ve yaşanılan enlem grupları arasında istatistiksel olarak anlamlı ilişki bulunmadı (p>0,05). Sonuç: Çalışmamızda D vitamini düzeylerinin hastalık EDSS skorları, atak sıklığı, MRG tutulumu ve ilgili klinik sistem sayısı üzerine etkisi olmadığı tespit edildi.

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Cite This Article

OZTURK, İ., PAK, A. T., GÜRKAN, Z. M., MUTLU, M., TOKSOY, C. K., YUKSEL, C. (2022). The Possible Effect Of Residence Area And Vitamin D Levels On Progression Of Multiple Sclerosis. Ege Klinikleri Tıp Dergisi, Cilt: 58 - Sayı: 1, 1–6. https://ajindex.com/articles/495652

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