Pregnancy Outcomes of Patients Diagnosed As Having Cleft Lip Or/and Cleft Palate In Antenatal Screening

Patients with CL±P with either major or minor additional ultrasonographic anomalies have worse fifth minute Apgar results and a greater need for the NICU.

📌 3 Key Takeaways

🎯

Objective & Hypothesis:To evaluate the obstetric outcomes of extra ultrasonographic anomalies in patients with cleft lip or/and cleft (CL±P) palate.This retrospective study was conducted in a tertiary referral hospital between December 2017 and March 2021.

📊

Key Findings & Data:The patients were analyzed under three groups as follows: isolated CL±P (group 1), CL±P with ultrasonographic anomalies with mild fetal and neonatal consequences (group 2), and CL±P with ultrasonographic anomalies with severe fetal and neonatal consequences (group 3).

💡

Conclusion & Impact:Patients with CL±P with either major or minor additional ultrasonographic anomalies have worse fifth minute Apgar results and a greater need for the NICU.

🔬Design:Research Article

📍Scope:2017 Verileri

⚙️Variables:Domain Parameters

Abstract

To evaluate the obstetric outcomes of extra ultrasonographic anomalies in patients with cleft lip or/and cleft (CL±P) palate.This retrospective study was conducted in a tertiary referral hospital between December 2017 and March 2021. The patients were analyzed under three groups as follows: isolated CL±P (group 1), CL±P with ultrasonographic anomalies with mild fetal and neonatal consequences (group 2), and CL±P with ultrasonographic anomalies with severe fetal and neonatal consequences (group 3). Fourty cases were analyzed. The abnormal karyotype result (16.7%) were 46,x,t (t15;16)(q26;24), monosomy 18, trisomy 13, 46, XX, 21ps +. In the central cleft, ultrasonographic anomalies were seen in nine patients, which was statistically significantly higher than in isolated CL±P (p=0.004). Seven patients with extra ultrasonographic anomalies underwent termination, one patient with anencephaly died in utero. Preterm birth was the most common obstetric complication in all groups (n=9, 27.2%). In group 3, polyhydramnios was observed statistically significantly more frequently than in group 2 (p=0.033), and the first minute APGAR score was statistically significantly lower than in group 1 and 2 (p=0.003). The fifth minute APGAR score was statistically significantly lower and the need for the neonatal intensive care unit was statistically significantly higher than group 1 only (p=0.004 and p=0.007, respectively). Polyhydramnios is not found in isolated cases, but only in cases with additional anomalies. Patients with CL±P with either major or minor additional ultrasonographic anomalies have worse fifth minute Apgar results and a greater need for the NICU.

🔖

Cite This Article

ÇELİK, Ö. Y., OBUT, M., DAĞDEVİREN, G., KELEŞ, A., KAHRAMAN, N. Ç., YILDIZ, G. A., ARAT, Ö., İSKENDER, C. (2022). Pregnancy Outcomes of Patients Diagnosed As Having Cleft Lip Or/and Cleft Palate In Antenatal Screening. Eastern Journal of Medicine, Cilt: 27 - Sayı: 2, 204–211. https://ajindex.com/articles/493860

📄 Full Text PDF Viewer

Open in New Tab ↗

↗New Tab

📄

PDF görüntüleyici hazırlanıyor...

References (8)

Worley ML, Patel KG, Kilpatrick LA. Cleft Lip and Palate. Clin Perinatol 2018;45(4):661-78.
Mai CT, Cassell CH, Meyer RE, et al. Birth defects data from population-based birth defects surveillance programs in the United States, 2007 to 2011: highlighting orofacial clefts. Birth Defects Res A Clin Mol Teratol 2014;100(11):895-904.
Burg ML, Chai Y, Yao CA, Magee W, 3rd, Figueiredo JC. Epidemiology, Etiology, and Treatment of Isolated Cleft Palate. Front Physiol 2016;7:67. Calzolari E, Pierini A, Astolfi G, et al. Associated anomalies in multi-malformed infants with cleft lip and palate: An epidemiologic study of nearly 6 million births in 23 EUROCAT registries. Am J Med Genet A 2007;143a(6):528-37. Cleft lip and palate. Cited 2021. Available from: https://www.omim.org/search?index=entry&sea rch=cleft+lip+and+palate&start=1&limit=10&re trieve=geneMap&genemap_exists=true. De Robertis V, Rembouskos G, Fanelli T, Votino C, Volpe P. Cleft Palate with or without Cleft Lip: The Role of Retronasal Triangle View and Maxillary Gap at 11-14 Weeks. Fetal Diagn Ther 2019;46(6):353-9.
Marginean C, Sasarean V, Marginean CO, Melit LE, Marginean MO. Prenatal diagnosis of cleft lip and cleft lip palate - a case series. Med Ultrason 2018;20(4):531-5. Practice Bulletin No. 175: Ultrasound in Pregnancy. Obstet Gynecol 2016;128(6):e241-e56. Salomon LJ, Alfirevic Z, Berghella V, et al. Practice guidelines for performance of the routine mid-trimester fetal ultrasound scan. Ultrasound Obstet Gynecol 2011;37(1):116-26. 1Fuchs F, Grosjean F, Captier G, Faure JM. The 2D axial transverse views of the fetal face: A new technique to visualize the fetal hard palate; methodology description and feasibility. Prenat Diagn 2017;37(13):1353-9.
Brusilov M, Wolman I, Ashwal E, Malinger G, Birnbaum R. Ultrasound imaging of the fetal secondary palate: Methodological description of a two-dimensional approach and a case series. Prenat Diagn 2018;38(13):1049-54.
Depla AL, Breugem CC, van der Horst CM, et al. Polyhydramnios in isolated oral cleft pregnancies: incidence and outcome in a retrospective study. Prenat Diagn 2017;37(2):162-7.
Wyszynski DF, Wu T. Prenatal and perinatal factors associated with isolated oral clefting. Cleft Palate Craniofac J 2002;39(3):370-5.
Zimmerman CE, Folsom N, Humphries LS, et al. What is the Impact of Prenatal Counseling on Postnatal Cleft Treatment? Multidisciplinary Pathway for Prenatal Orofacial Cleft Care. J Craniofac Surg 2021. ACOG Practice Bulletin No. 102: manag