Journals / Fırat Tıp Dergisi / 2022 / Cilt: 27 - Sayı: 1

The Role of the Systemic İnflammatory Markers in the Clinical Follow-Up of Pregnant Women with Preterm Premature Rupture of Membranes

Preterm Erken Membran Rüptürü olan Gebelerin Klinik İzleminde Sistemik İnflamatuar Belirteçlerin Rolü

Pages
43–47
Publication Date
2022-10-18
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

CRP, Inflammatory Marker, Leukocyte, Preterm Premature Rupture of Membranes (PPROM).

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: To investigate the role of Neutrophil-Lymphocyte ratio (NLR), Lymphocyte-Monocyte ratio (LMR), Platelet-Lymphocyte ratio (PLR), Mean Platelet Volume (MPV), C- reactive protein (CRP) values in determining of the time until delivery after preterm premature rupture of membranes (PPROM).
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Key Findings & Data:Material and Method: The study data were collected from the hospital records between January 2017 and December 2018.
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Conclusion & Impact:CRP, Inflammatory Marker, Leukocyte, Preterm Premature Rupture of Membranes (PPROM).
🔬Design:Research Article
📍Scope:2017 Verileri
⚙️Variables:Domain Parameters

Abstract

Objective: To investigate the role of Neutrophil-Lymphocyte ratio (NLR), Lymphocyte-Monocyte ratio (LMR), Platelet-Lymphocyte ratio (PLR), Mean Platelet Volume (MPV), C- reactive protein (CRP) values in determining of the time until delivery after preterm premature rupture of membranes (PPROM). Material and Method: The study data were collected from the hospital records between January 2017 and December 2018. The patients with pprom, below 34 weeks of gestation were included in the study. The CRP, NLR, LMR, PLR and MPV values of the patients were obtained from the blood sample taken at the first admission before antibiotic prophylaxis and betamethasone dose for lung maturation. The patients were divided into two groups; the patients in group 1 were defined as those who started spontaneous delivery in the first 72 hours, and the ones in group 2 as those who started spontaneous delivery after 72 hours. The two groups were compared in terms of their CRP, NLR, LMR, PLR and MPV values. Results: The study included 172 patients who met the inclusion criteria. There was no significant difference between the two groups in terms of PLR and MPV values. CRP, NLR and LMR mean values of group I and group II were calculated as (1.08; 6.68; 3.00 and 0.75; 4.74; 4.07) respectively (p =0.012, p =0.001, p =0.001 ). Conclusion: In the patients with pprom, high NLR, CRP and low LMR values may be helpful to predict delivery within 72 hours and provide appropiate patient counseling. CRP, Inflammatory Marker, Leukocyte, Preterm Premature Rupture of Membranes (PPROM).

Özet

Amaç: Preterm erken membran rüptürü (PEMR ) sonrası, doğuma kadar geçen sürenin belirlenmesinde, Nötrofil -Lenfosit oranı (NLR), Lenfosit- Monosit oranı (LMR), Trombosit-Lenfosit oranı (PLR), Ortalama Trombosit Hacmi (MPV) ve C- reaktif protein (CRP) değerlerinin rolünü araştırmaktır. Gereç ve Yöntem: Çalışmada kullanılan veriler, kurumsal inceleme kurulumuzun onayı alınarak Ocak 2017 ile Aralık 2018 tarihleri arası hastane kayıtlarından toplanmıştır. Aktif doğum eyleminde olmayan, 34 gebelik haftasının altındaki PEMR tanısı alan hastalar çalışmaya dahil edilmiştir. Tüm hastaların CRP, NLR, LMR, PLR ve MPV değerleri, hastalara antibiyotik profilaksisi ve akciğer maturasyonu için betametazon dozu verilmeden, ilk başvuru anında alınan laboratuvar testlerinden elde edilmiştir. Hastalar membran rüptüründen doğuma kadar geçen zamana göre iki gruba ayrılmış; Grup 1'deki hastalar ilk 72 saatte spontan doğum eylemi başlayanlar, Grup 2'deki hastalar ise 72 saatten sonra spontan doğum eylemi başlayanlar olarak tanımlanmıştır. İki grup CRP, NLR, LMR, PLR ve MPV değerleri açısından karşılaştırılmıştır. Bulgular: Çalışmaya kriterleri sağlayan 172 hasta dahil edilmiştir. Grup 1’de Grup 2’ye göre CRP (ortanca değerler sırasıyla 1,08 ve 0,75 (p =0,012)) ve NLR (ortanca değerleri sırasıyla 6,68 ve 4,74 (p =0,001)) daha yüksek saptanırken, LMR (ortanca değerler sırasıyla 3,00 ve 4,07 (p =0,001)) daha düşük saptanmıştır. Sonuç: PEMR olan hastalarda doğuma kadar geçen sürenin kısa olması yüksek NLR ve CRP ile düşük LMR değerleri ile ilişkilidir. Bu hastalara danışmanlık verilebilmesinde ve hastaların takibiyle ilgili koşulların belirlenmesinde yardımcı olabilir.

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Cite This Article

ŞAHİN, D., ŞAHİN, D., YÜCEL, A., ÇELİK, Ö. Y., KELEŞ, A. İ., DAĞDEVİREN, G. (2022). The Role of the Systemic İnflammatory Markers in the Clinical Follow-Up of Pregnant Women with Preterm Premature Rupture of Membranes. Fırat Tıp Dergisi, Cilt: 27 - Sayı: 1, 43–47. https://ajindex.com/articles/513386

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References (15)

  1. Prelabor Rupture of Membranes: ACOG Practice Bulletin, Number 217. Obstetrics & Gynecology 2020; 135: 80-97
  2. Simhan HN, Canavan TP. Preterm premature rupture of membranes: diagnosis, evaluation and management strategies. BJOG 2005; 112: 32-7
  3. Romero R, Espinoza J, Gonçalves LF, Kusanovic JP, Friel L, Hassan S. The role of inflammation and infection in preterm birth. Semin Reprod Med 2007; 25: 21-39
  4. Romero R, Miranda J, Chaemsaithong P et al. Sterile and microbial-associated intra-amniotic inflammation in preterm prelabor rupture of membranes. J Matern Fetal Neonatal Med 2015; 28: 1394-409
  5. Isık H, Aynıoglu O, Sahbaz A et al. Can plateletcrit, an underestimated platelet parameter, be related with preterm labour? J Obstet Gynaecol 2015; 35: 676-80
  6. Ekin A, Gezer C, Kulhan G, Avcı ME, Taner CE. Can platelet count and mean platelet volume during the first trimester of pregnancy predict preterm premature rupture of membranes? J Obstet Gynaecol Res 2015; 41: 23-8
  7. Gioia S, Piazze J, Anceschi MM et al. Mean platelet volume: association with adverse neonatal outcome. Platelets 2007; 18: 284-8
  8. Gabay C, Kushner I. Acute-phase proteins and other systemic responses to inflammation. N Engl J Med 1999; 340: 448-54
  9. Liu JF, Ba L, Lv H et al. Association between neutrophil-to-lymphocyte ratio and differentiated thyroid cancer: a meta-analysis. Sci Rep 2016; 6: 38551
  10. Leader A, Pereg D, Lishner M. Are platelet volume indices of clinical use? A multidisciplinary review. Ann Med 2012; 44: 805-16
  11. Okyay GU, Inal S, Oneç K et al. Neutrophil to lymphocyte ratio in evaluation of inflammation in patients with chronic kidney disease. Ren Fail 2013; 35: 29-36
  12. Turkmen K, Erdur FM, Ozcicek F et al. Plateletto- lymphocyte ratio better predicts inflammation than neutrophil-to-lymphocyte ratio in end-stage renal disease patients. Hemodial Int 2013; 17: 391- 6
  13. Lee JS, Kim NY, Na SH, Youn YH, Shin CS. Reference values of neutrophil-lymphocyte ratio, lymphocyte-monocyte ratio, platelet-lymphocyte ratio, and mean platelet volume in healthy adults in South Korea. Medicine (Baltimore) 2018; 97: 11138
  14. Ying HQ, Deng QW, He BS et al. The prognostic value of preoperative NLR, d-NLR, PLR and LMR for predicting clinical outcome in surgical colorectal cancer patients. Med Oncol 2014; 31: 305
  15. Sari I, Sunbul M, Mammadov C et al. Relation of neutrophil-to-lymphocyte and platelet-tolymphocyte ratio with coronary artery disease severity in patients