AI Summary & Key Takeaways
AI InsightWe maintain that further experimental studies should be carried out, as there are few studies investigating the late stage effects of external radiotherapy in patients with arteriovenous fistulae. (Turkish J Vase Sur 2008;17(l):13-19).
📌 3 Key Takeaways
Abstract
Purpose: To investigate the impact of radiation therapy, administered to break the hyperplastic chain of events in the organism, on intimal hyperplasia which is also a hyperplastic and proliferative event. Methods: The effect of external radiotherapy at a dose of 2000 cGy on intimal hyperplasia in an arteriovenous fistula vein anastomosis in the artery system was investigated. Therefore, a total of 20 rabbits induced with femoral arteriovenous anastomosis were administered with 2000 cGy external radiation therapy within the first 24 hours following surgery. Of those, four groups were formed. While Group 1 and 3 were the controls; Group 2 was formed on day 28 with 10 subjects and Group 4 was formed on day 90, also with 10 subjects. Results: Group 2 and 4 were compared against the control groups (Group 1 and 3) in terms of intimal hyperplasia development at ocular micrometric level. While the difference between Group 2 and the control group (Group 1) was statistically significant with a p value of 0.05. Conclusion: It was observed that 2000 cGy single dose external radiotherapy administered within the first 24 hours following arteriovenous fistulae formation decreased venous intimal hyperplasia significantly. Although it had a decreasing effect in the long-term as well, the effect was not statistically significant. We maintain that further experimental studies should be carried out, as there are few studies investigating the late stage effects of external radiotherapy in patients with arteriovenous fistulae. (Turkish J Vase Sur 2008;17(l):13-19).
Özet
Amaç: Organizmada hiperplastik gelişimleri azaltan radyoterapinin, yine bir hiperplastik ve proliferatif gelişim olan intimal hiperplaziyi de azaltıcı etkisi olabilir. Arteriyovenöz fistüllerde vendeki intimal hiperplaziye external uygulanan 2000 cGy radyoterapinin etkisi bu çalışmada araştinlmıştır. Yöntem: Bu amaçla femoral arteriyovenöz anastomoz oluşturulan 20 adet tavşana ameliyat sonrası ilk 24 saat içinde 2000 cGy external radyoterapi verilmiştir. Bunların 10 tanesinde 28 gün sonra (grup 2); 10 tanesinde 3 ay sonra (grup 4) kontrol grupları olan Grup (1 ve 3) e göre oküler mikrometrik düzeyde intimal hiperplazi gelişiminin farkı araştırılmıştır. Bulgular: Grup 2 de kontrol grubu olan grup l'e göre fark p 0.05 değeri ile istatistiksel olarak anlamsız görülmüştür. Sonuç: Arteriyovenöz fistüllere ilk 24 saat içinde verilen external radyoterapinin, venöz intimal hiperplaziyi erken dönemde azalttığı; geç dönemde azaltsa da bunun istatistiksel olarak anlamlı olmadığı görüldü. Arteriyovenöz fistüllerde external radyoterapinin geç dönem etkilerinin konuyla ilgili çok az yayın olması nedeniyle, deneysel olarak desteklenmesi kanısındayız. (Damar Cer Der 2008;17(l): 13-19).