Journals / Dicle Tıp Dergisi / 2022 / Cilt: 49 - Sayı: 1

The Measurement of Neutrophil Gelatinase Associated Lipocalin in Umbilical Cord Blood and the Assessment of Its Relationship with Neonatal Results

Pankreas Kanseri Tanılı Hastalarımızda Prognostik Faktörlerin İncelenmesi

Pages
159–167
Publication Date
2022-03-11
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

However, studies on larger patient populations are needed.

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives: In this study, the relationship of cord blood Neutrophil Gelatinase-Associated Lipocalin (NGAL) with neonatal diseases was investigated.
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Key Findings & Data:Methods: NGAL levels were measured in the cord blood of 180 babies born between 2015 and 2016.
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Conclusion & Impact:However, studies on larger patient populations are needed.
🔬Design:Research Article
📍Scope:2015 Verileri
⚙️Variables:Pankreas kanseri · Tümör markırları · Prognostik faktörler

Abstract

Objectives: In this study, the relationship of cord blood Neutrophil Gelatinase-Associated Lipocalin (NGAL) with neonatal diseases was investigated. Methods: NGAL levels were measured in the cord blood of 180 babies born between 2015 and 2016. Patients were classified according to maternal diseases, neonatal diseases and demographic characteristics. Obtained data were compared with cord blood NGAL levels. Results: In our study, the mean NGAL levels were 1283.99 ng/mL in boys and 1306.52 ng/mL in girls. Umbilical cord blood NGAL levels of infants diagnosed with intrauterine growth retardation (1913.4±2833.5 ng/mL) and prolonged premature rupture of membranes (2594.2±2037.1 ng/mL) were found to be statistically high (p0.05). Conclusions: Neutrophil Gelatinase-Associated Lipocalin, may be useful as a diagnostic biomarker in the evaluation of maternal and neonatal diseases. However, studies on larger patient populations are needed.

Özet

Amaç: Pankreas kanseri oldukça kötü prognozlu bir hastalık olup, insidansı giderek artmaktadır. Bu hastalıkta birden fazla prognostik belirteç bulunmaktadır. Bu çalışmadaki amaç kliniğimizde pankreas kanseri tanısı alan hastaların yaşam süresini etkileyen prognostik faktörleri saptamaktı. Yöntemler: Kliniğimize Ocak 2011-Haziran 2020 tarihleri arasında başvuran ve pankreas kanseri tanısı konulan 127 hastanın demografik ve klinik özellikleri, laboratuvar sonuçları, kontrastlı abdomen tomografisi bulguları ve tedavilere cevapları retrospektif olarak değerlendirildi. Bulgular: Hastaların 85’i (%67) erkek 42’si (%33) kadın olup, yaş ortalaması 62,6±12,5 (27-90) yıl, ortalama sağ kalma süresi 11,6±1,3 ay; 1 yıllık ortalama sağ kalım oranı %31 ve 5 yıllık ortalama sağ kalım oranı %0,9 idi. Pankreas kanseri prognozu ile cinsiyet, tümör çapı, tümör lokalizasyonu, DM varlığı, patolojik LAP varlığı, vasküler invazyon, kemoterapi alınması, serum CA 19-9 ve CA125 seviyesi arasında anlamlı ilişki saptanmazken, ileri yaş (p=0.01), karaciğer metastazı (P=0.016) ve yüksek serum CEA düzeyinin (p=0.013) kötü prognostik faktör ve cerrahi rezeksiyon yapılmasının (p=0.039) iyi prognostik faktör olduğu saptandı. Sonuç: Pankreas kanseri tedavisi sırasında hastalığın prognozunu etkileyen faktörlerin göz önünde bulundurulması faydalı olabilir.

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Cite This Article

YOLAÇAN, R., YİĞİT, E., KARABULUT, Ü., ÜZEL, A., UÇMAK, F., KAYA, M. (2022). The Measurement of Neutrophil Gelatinase Associated Lipocalin in Umbilical Cord Blood and the Assessment of Its Relationship with Neonatal Results. Dicle Tıp Dergisi, Cilt: 49 - Sayı: 1, 159–167. https://ajindex.com/articles/484874

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