Journals / Dicle Tıp Dergisi / 2026 / Cilt: 53 Sayı: 3

Valproic Acid–Induced Hyperammonemic Encephalopathy: A Case Report

Rıdvan Toprak(UNIVERSITY OF HEALTH SCIENCES, HEALTH RESEARCH CENTER)
Rukiye Ay(University of Health Sciences, Bursa Yuksek Ihtisas Training and Research Hospital)
Pages
757–759
Publication Date
2026-09-11
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

This article presents a case demonstrating that valproic acid, which is widely used in the treatment of bipolar disorder, can lead to hyperammonemic encephalopathy, a rare but potentially serious adverse effect.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:This article presents a case demonstrating that valproic acid, which is widely used in the treatment of bipolar disorder, can lead to hyperammonemic encephalopathy, a rare but potentially serious adverse effect.
📊
Key Findings & Data:This article presents a case demonstrating that valproic acid, which is widely used in the treatment of bipolar disorder, can lead to hyperammonemic encephalopathy, a rare but potentially serious adverse effect.
💡
Conclusion & Impact:This article presents a case demonstrating that valproic acid, which is widely used in the treatment of bipolar disorder, can lead to hyperammonemic encephalopathy, a rare but potentially serious adverse effect.
🔬Design:Editöre Mektup
📍Scope:Comprehensive Sample
⚙️Variables:Hiperammonemik · Ensefalopati · Valproik asit.

Abstract

This article presents a case demonstrating that valproic acid, which is widely used in the treatment of bipolar disorder, can lead to hyperammonemic encephalopathy, a rare but potentially serious adverse effect.

Özet

Bu yazıda, bipolar duygudurum bozukluğu tedavisinde yaygın olarak kullanılan valproik asidin, nadir ancak potansiyel olarak ciddi bir yan etkisi olan hiperamonyemik ensefalopatiye yol açabileceğini gösteren bir olgu sunulmaktadır.

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Cite This Article

Ay, R. (2026). Valproic Acid–Induced Hyperammonemic Encephalopathy: A Case Report. Dicle Tıp Dergisi, Cilt: 53 Sayı: 3, 757–759. https://doi.org/10.5798/dicletip.2037497

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References (8)

  1. Koroglu E. Mood stabilizers. Clinical Psychiatry,3rd ed. Esenkal Publishing, 2020: 808-10.
  2. Ahmad S. Psychopharmacology. In: Sarikaya BB,Bozkurt A, eds. Kaplan & Sadock's Pocket Handbookof Clinical Psychiatry, 7th ed. Ankara: Gunes MedicalBookstores, 2023: 671-6.
  3. Baddour E, Tewksbury A, Stauner N. Valproic acid-induced hyperammonemia: incidence, clinicalsignificance, and treatment management. MentHealth Clin. 2018; 8: 73-7.
  4. Carr RB, Shrewsbury K. Hyperammonemia due tovalproic acid in a psychiatric setting. Am JPsychiatry. 2007; 164: 1020-7.
  5. Wong YJ, Fan J, Wan A, et al. Valproic acid-associated hyperammonemia: a systematic review. JClin Psychopharmacol. 2023; 43: 283-94.
  6. Wadzinski J, Franks R, Roane D, et al. Valproate-associated hyperammonemic encephalopathy. J AmBoard Fam Med. 2007; 20: 499-502.
  7. Segura-Bruna N, Rodriguez-Campello A, Puente V,et al. Valproate-induced hyperammonemicencephalopathy. Acta Neurol Scand. 2006; 114: 1-7.
  8. Yoo JY, Yang HS. Valproate-inducedhyperammonemic encephalopathy: a case report.Brain Neurorehabil. 2013; 6: 86-9.