SavedAdd your journal

Journals / Cumhuriyet Üniversitesi Fen-Edebiyat Fakültesi Fen Bilimleri Dergisi / 2016 / Cilt: 37 - Sayı: 1

The Usage of Rosa canina L. Extracts As a Natural Anti-Genotoxic Agents Against the Genotoxicity of Profenofos on Somatic Cells by Different Test Systems

Farklı Test Sistemleri ile Somatik Hücrelerde Profenofos Genotoksisitesine Karşı Kuşburnu (Rosa canina L.) Ekstrelerinin Doğal Bir Antigenotoksik Ajan Olarak Kullanılması

Caner KASIMOĞLU
Handan UYSAL
Pages
30–40
Publication Date
2022-10-11
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

When the water (RCwtr) and ethanol (RCeth) extracts of the rosehip plants were applied together with the highest application concentration of profenofos (profenofos+ RCwtr/RCeth), it was observed that the increase in the mutation frequency decreased and this decrease was statistically significant (P

📌 3 Key Takeaways

🎯
Objective & Hypothesis:In this study, the genotoxic effects of profenofos insecticide were investigated with the somatic mutation and recombination test (SMART) in Drosophila melanogaster and the micronucleus test (MN) in human peripheral lymphocytes.
📊
Key Findings & Data:When the wing preparates of D.melanogaster were examined for the SMART, it was observed that mutation frequency in normal wing phenotype increased depending on doses of profenofos (0,025, 0,05, 0,075 ve 0,1ppm) and this increase was positive effect (+) in the highest application group (0,1 ppm), especially.
💡
Conclusion & Impact:When the water (RCwtr) and ethanol (RCeth) extracts of the rosehip plants were applied together with the highest application concentration of profenofos (profenofos+ RCwtr/RCeth), it was observed that the increase in the mutation frequency decreased and this decrease was statistically significant (P
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

In this study, the genotoxic effects of profenofos insecticide were investigated with the somatic mutation and recombination test (SMART) in Drosophila melanogaster and the micronucleus test (MN) in human peripheral lymphocytes. The water and ethanol extracts of rosehip plants (Rosa canina) were used to remove possible genotoxic effects of this substance. When the wing preparates of D.melanogaster were examined for the SMART, it was observed that mutation frequency in normal wing phenotype increased depending on doses of profenofos (0,025, 0,05, 0,075 ve 0,1ppm) and this increase was positive effect (+) in the highest application group (0,1 ppm), especially. The increase in mutation frequency of the serrate wings phenotype was found insignificant (i) in the all application groups (P>0,05). When the water (RCwtr) and ethanol (RCeth) extracts of the rosehip plants were applied together with the highest application concentration of profenofos (profenofos+ RCwtr/RCeth), it was observed that the increase in the mutation frequency decreased and this decrease was statistically significant (P

Özet

Bu çalışmada, profenofos insektisitinin genotoksik etkileri, Drosophila melanogaster'de somatik mutasyon ve rekombinasyon testi (SMART) ve insan periferal lenfosit hücrelerinde mikronükleus (MN) testi ile araştırılmıştır. Bu maddenin olası genotoksik etkilerinin giderilebilmesi için de kuşburnu (Rosa canina) bitkisine ait su ve etanol ekstreleri kullanılmıştır. SMART için D.melanogaster'in kanat preparatları incelendiği zaman, profenofosun artan konsantrasyonuna (0,025, 0,05, 0,075 ve 0,1ppm) bağlı olarak normal kanat fenotipinde mutasyon frekansının arttığı özellikle en yüksek uygulama grubunda (0,1 ppm) bu artışın pozitif etkili (+) olduğu gözlenmiştir (P0,05). Kuşburnu bitkisinin su (RCsu) ve etanol (RCeta) ekstreleri, profenofosun en yüksek konsantrasyonu (0,1 ppm) ile birlikte uygulandığı zaman (profenofos+ RCsu/RCeta) mutasyon frekansındaki artışın azaldığı ve bunun da istatistiksel olarak önemli olduğu gözlenmiştir (P

🔖

Cite This Article

KASIMOĞLU, C., UYSAL, H. (2022). The Usage of Rosa canina L. Extracts As a Natural Anti-Genotoxic Agents Against the Genotoxicity of Profenofos on Somatic Cells by Different Test Systems. Cumhuriyet Üniversitesi Fen-Edebiyat Fakültesi Fen Bilimleri Dergisi, Cilt: 37 - Sayı: 1, 30–40. https://ajindex.com/articles/480387

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (10)

  1. Moustafa G.G., Ibrahim Z.S., Hashimoto Y., Alkelch A.M., Sakamoto K.Q., Ishizuka M., Fujita S., (2007). Testicular toxicity of profenofos in matured male rats. Arch Toxicol, 81, 875-881.
  2. Habiba R.A., Ali H.M., Ismail S.M., (1992). Biochemical effects of profenofos residues in potatoes. J. Agric. Food Chem, 40, 1852-1855.
  3. He J., Fan M., Liu X., (2010). Environmental behavior of profenofos under paddy field conditions. Bull Environ Contam Toxicol, 84, I771-774. İsmail M., Ali R., Ali T., Waheed U., Khan Q.M., (2009). Evaluation of the acute toxicity of profenofos and its effects on the behavioral pattern of fingerling common carp (Cyprinus carpio L., 1758). Bull Environ Contam Toxicol; 82, 569-573.
  4. Hammam F.M., Abd el Mottaleb E.M., (2007). Studies of the genotoxic and histopathological effects of the organophosphorous insecticide 'profenofos' on white rats. The Egypt J Hosp Med, 29, 685-706.
  5. Prabhavathy Das G., Pash A., Jamil S., Jamil K., (2006). Estimation of apoptosis and necrosis caused by pesticides In Vitro on human lymphocytes using DNA diffusion assay. Drug Chem Toxicol, 29, 147-156.
  6. Li X., Li S., Liu S., Zhu G., (2010). Lethal effect and in vivo genotoxicity of profenofos to Chinese native amphibian (Rana spinosa) tadpoles. Arch Environ Contam Toxicol, 59, 478- 483 Principe P., (1991). Monetizing the Pharmacological Benefits of Plants, US Environmental Protection Agency, Washington DC. Cowan M.M., (1999). Plant products as antimicrobial agents. Clin Microbiol Rev; 12, 564- 582. Tumbas V.T., Canadanovic-Brunet J.M., Cetojevic-Simin D.D., Cetkovic G.S., Dilas S.M., Gille L., (2012). Effect of rosehip (Rosa canina L.) phytochemicals on stable free radicals and human cancer cells. J Sci Food Agric, 92, 1273-1281.
  7. Willich S.N., Rossnagel K., Roll S., Wagner A., Mune O., Erlendson J., Kharazmi A., Sörensen H., Winther K., (2010). Rose hip herbal remedy in patients with rheumatoid arthritis - a randomised controlled trial. Phytomedicine, 17, 87-93.
  8. Orhan N., Aslan M., Hosbas S., Deliorman O.D., (2009). Antidiabetic affect and antioxidant potential of Rosa canina fruits. Phcog Mag, 5, 309-315.
  9. Pieroni A., Quave C.L., (2005). Traditional pharmacopoeias and medicines among Albanians and Italians in southern Italy: A comparison. J Ethnopharmacol 101, 258-270. Ercisli S., (2007). Chemical composition of fruits in some rose (Rosa spp.) species. Food Chem, 104, 1379-1384.
  10. Montazeri N., Baher E., Mirzajani F., Barami Z., Yousefian S., (2011). Phytochemical conten