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Journals / Cumhuriyet Dental Journal / 2021 / Cilt: 24 - Sayı: 3

EFFECT OF TIDEGLUSIB WITH BONE GRAFTING ON NEW BONE FORMATION

Berrin İyilikci
Ufuk Taşdemir
Özlem Özmen
Alper Kızıldağ
Pages
224–231
Publication Date
2022-10-11
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusions: Our results demonstrated that Tideglusib, in combination with bone grafting has an adjuvant effect on BMP-2 and VEGF-A expressions that may accelerate bone regeneration.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objectives: The goal of this study was to observe the regenerative potential of Tideglusib in combination with autogenous and xenograft mandibular defects in rats.
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Key Findings & Data:In 40 Wistar albino rats, 5-mm-diameter critical bone defects were created at the angle of the mandible.
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Conclusion & Impact:Conclusions: Our results demonstrated that Tideglusib, in combination with bone grafting has an adjuvant effect on BMP-2 and VEGF-A expressions that may accelerate bone regeneration.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objectives: The goal of this study was to observe the regenerative potential of Tideglusib in combination with autogenous and xenograft mandibular defects in rats. Material Methods: Our study consists of five groups: one control and four experimental. In 40 Wistar albino rats, 5-mm-diameter critical bone defects were created at the angle of the mandible. In the control group, the defect was not filled. The defects were grafted only Xenograft in Group 1, with Xenograft and tideglusib in Group 2, and with only autogenous bone graft in Group3, and with autogenous bone graft mixed with tideglusib in Group 4. Results: Sterological analyses revealed that enhanced new bone formation in the Group 4 compare to Control and Group 1. Immunohistochemically marked expressions of BMP-2 and VEGF were observed in Group 4. Conclusions: Our results demonstrated that Tideglusib, in combination with bone grafting has an adjuvant effect on BMP-2 and VEGF-A expressions that may accelerate bone regeneration.

Özet

Bu çalışmanın amacı, otojen ve ksenojen kemik greftlerle karıştılarılan Tideglusib’in ratlarda oluşturulan kemik defektlerindeki rejeneratif potansiyelinin incelenmesidir. Çalışma bir kontrol ve dört deney grubu olmak üzere beş gruptan oluşmaktadır. Rat mandibula angulus bölgesinde, 5 mm çapında kritik kemik defekti oluşturulmuştur. Kontrol grubunda defektler boş bırakılmıştır. Grup 1 de defektlere sadece Ksenojen kemik greft, Grup 2 de Ksenojen kemik greft ve Tideglusib, Grup 3 de sadece otojen kemik greft ve Grup 4 de ise otojen kemik greft tideglusib ile karıştırılarak uyugulanmıştır. Sterelojik analiz sonuçlarına göre yeni kemik formasyonu, Grup 1 ve Kontrol Grubu ile karşılaştırıldığında Grup 4’ de daha fazla oluşmuştur. Grup 4 de immunohistokimyasal olarak daha fazla hacimde BMP-2 ve VEGF ekspresyonu gözlemlenmiştir. Çalışmamızın sonuçları; Tideglusib ile karıştılan kemik greftlerin BMP-2 ve VEGF ekspresyonununu artırdığını ve bu durumunda kemik rejenerasyonunu geliştirdiğini göstermektedir.

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Cite This Article

İyilikci, B., Taşdemir, U., Özmen, Ö., Kızıldağ, A. (2022). EFFECT OF TIDEGLUSIB WITH BONE GRAFTING ON NEW BONE FORMATION. Cumhuriyet Dental Journal, Cilt: 24 - Sayı: 3, 224–231. https://ajindex.com/articles/476877

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