Journals / Cardiovascular surgery and interventions / 2022 / Cilt: 9 - Sayı: 2

Evaluation of a gold nanocomposite hyaluronic acid-based adhesion barrier with antibacterial properties in an animal model

Pages
104–110
Publication Date
2022-10-12
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

However, both low inflammatory cells (p

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objectives: In this study, the effects of a gold nanocomposite hyaluronic acid-based adhesion barrier were evaluated in an animal model.
📊
Key Findings & Data:Materials and methods: In our study, a total of 42 rats in seven groups, with six rats in each group, were evaluated.
💡
Conclusion & Impact:However, both low inflammatory cells (p
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objectives: In this study, the effects of a gold nanocomposite hyaluronic acid-based adhesion barrier were evaluated in an animal model. Materials and methods: In our study, a total of 42 rats in seven groups, with six rats in each group, were evaluated. The groups were established according to the application of an adhesion barrier. In the first, second, and third groups, an adhesion barrier was applied by standard median laparotomy in the first, second, and fourth weeks, respectively. The fourth, fifth, and sixth groups underwent the same procedure in the first, second, and fourth weeks; however, no adhesion barrier was applied to these groups. The seventh group was the control group, and no treatment was performed in this group. Results: There was no significant difference in the formation of inflammatory cells and fibrous tissue between the groups that underwent laparotomy in the first and second weeks with and without the adhesion barrier (p>0.05). However, both low inflammatory cells (p

🔖

Cite This Article

KASIMZADE, F., MENDİL, A. S., ÖZKARACA, M., ADA, F. (2022). Evaluation of a gold nanocomposite hyaluronic acid-based adhesion barrier with antibacterial properties in an animal model. Cardiovascular surgery and interventions, Cilt: 9 - Sayı: 2, 104–110. https://ajindex.com/articles/470984

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (13)

  1. Weibel MA, Majno G. Peritoneal adhesions and their relation to abdominal surgery. A postmortem study. Am J Surg 1973;126:345-53
  2. Postoperative adhesion development after operative laparoscopy: Evaluation at early second-look procedures. Operative Laparoscopy Study Group. Fertil Steril 1991;55:700-4
  3. DeCherney AH, diZerega GS. Clinical problem of intraperitoneal postsurgical adhesion formation following general surgery and the use of adhesion prevention barriers. Surg Clin North Am 1997;77:671-88
  4. Menzies D, Ellis H. Intestinal obstruction from adhesions--how big is the problem? Ann R Coll Surg Engl 1990;72:60-3
  5. Ray NF, Denton WG, Thamer M, Henderson SC, Perry S. Abdominal adhesiolysis: Inpatient care and expenditures in the United States in 1994. J Am Coll Surg 1998;186:1-9
  6. Coleman MG, McLain AD, Moran BJ. Impact of previous surgery on time taken for incision and division of adhesions during laparotomy. Dis Colon Rectum 2000;43:1297-9
  7. Parker MC, Ellis H, Moran BJ, Thompson JN, Wilson MS, Menzies D, et al. Postoperative adhesions: Ten-year followup of 12,584 patients undergoing lower abdominal surgery. Dis Colon Rectum 2001;44:822-9
  8. Fazio VW, Cohen Z, Fleshman JW, van Goor H, Bauer JJ, Wolff BG, et al. Reduction in adhesive small-bowel obstruction by Seprafilm adhesion barrier after intestinal resection. Dis Colon Rectum 2006;49:1-11
  9. Hellebrekers BW, Kooistra T. Pathogenesis of postoperative adhesion formation. Br J Surg 2011;98:1503-16
  10. Prevention of postsurgical adhesions by INTERCEED(TC7), an absorbable adhesion barrier: A prospective randomized Barrier Study Group. Fertil Steril 1989;51:933-8
  11. Haney AF, Doty E. Murine peritoneal injury and de novo adhesion formation caused by oxidizedregenerated cellulose (Interceed [TC7]) but not expanded polytetrafluoroethylene (Gore-Tex Surgical Membrane). Fertil Steril 1992;57:202-8
  12. Becker JM, Dayton MT, Fazio VW, Beck DE, Stryker SJ, Wexner SD, et al. Prevention of postoperative abdominal adhesions by a sodium hyaluronate-based bioresorbable membrane: A prospective, randomized, double-blind multicenter study. J Am Coll Surg 1996;183:297-306. 13. van Steensel S, Liu H, Vercoulen TF, Hadfoune M, Breukink SO, Stassen LP, et al. Prevention of intra-abdominal adhesions by a hyaluronic acid gel; an experimental study in rats. J Biomater Appl 2021;35:887-97
  13. Papparella A, Nino F, Coppola S, Noviello C, Paciello O, Papparella S. Peritoneal morphological changes due to pneumo