Journals / Batı Karadeniz Tıp Dergisi / 2021 / Cilt: 5 - Sayı: 3

Brain Health and B Vitamins in Ageing

Yaşlanmada Beyin Sağlığı ve B Vitamini

Pages
331–336
Publication Date
2022-10-12
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In this review, we examine B vitamins, one carbon metabolism, and the role of B vitamins to aging brain.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:B vitamins are water-soluble vitamins and have important biological roles.
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Key Findings & Data:The decrease in these functions is a progressive condition that begins as mild cognitive impairment and progresses to dementia.
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Conclusion & Impact:In this review, we examine B vitamins, one carbon metabolism, and the role of B vitamins to aging brain.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

B vitamins are water-soluble vitamins and have important biological roles. Each B vitamin is a cofactor or essential precursor for key metabolic processes. Cognitive functions are various brain functions that include memory, learning, spatial orientation, reasoning, judgment, and evaluation. The decrease in these functions is a progressive condition that begins as mild cognitive impairment and progresses to dementia. Low intake of B vitamins is associated with a one carbon metabolism, which increases the risk of cognitive impairment and contributes to aging-related diseases. In this review, we examine B vitamins, one carbon metabolism, and the role of B vitamins to aging brain.

Özet

B vitaminleri suda çözünebilen vitaminler olup, önemli biyolojik rollere sahiptirler. Her B vitamini, anahtar metabolik süreçler için kofaktördür veya gerekli birer öncüdür. Bilişsel işlevler; hafıza, öğrenme, uzamsal yönelim, akıl yürütme, yargılama ve değerlendirmeyi içeren çeşitli beyin fonksiyonlarıdır. Bu işlevlerin azalması, hafif kognitif bozukluk olarak başlayan ve demansa kadar giden ilerleyici bir durumdur. B vitaminlerinin düşük düzeyde alınması sonucu kognitif bozukluk riskinin artması ve yaşlanmaya bağlı hastalıklara katkıda bulunması tek karbon metabolizması ile ilişkilidir. Bu derlemede B vitaminlerini, tek karbon metabolizmasını ve B vitaminlerinin yaşlanmada beyin sağlığı üzerindeki rolünü inceledik.

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Cite This Article

HAMAMCIOĞLU, A. C., KARABAŞ, E. G. (2022). Brain Health and B Vitamins in Ageing. Batı Karadeniz Tıp Dergisi, Cilt: 5 - Sayı: 3, 331–336. https://ajindex.com/articles/463114

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References (10)

  1. Bhargava S, Bhandari A, Choudhury S. Role of Homocysteine in Cognitive Impairement and Alzheimer’s Disease. Indian J Clin Biochem 2018; 33(1): 16-20
  2. Selhub J. Folate, vitamin B12 and vitamin B6 and one carbon metabolism. J Nutr Health Aging 2002; 6 (1): 39-42
  3. Porter K, Hoey L, Hughes CF, Ward M, McNulty H. Causes, Consequences and Public Health Implications of Low B-Vitamin Status in Ageing. Nutrients 2016; 8(11): 725
  4. Lyon P, Strippoli V, Fang B and Cimmino L. B Vitamins and One-Carbon Metabolism: Implications in Human Health and Disease Nutrients 2020; 12: 2867
  5. Green R, Allen LH, Bjørke-Monsen AL, Brito A, Guéant JL, Miller JW, Molloy AM, Nexo E, Stabler S, Toh BH, Ueland PM, Yajnik C. Vitamin B(12) deficiency. Nat Rev Dis Primers 2017; 3: 17040
  6. Seshadri S, Beiser A, Selhub J, Jacques PF, Rosenberg IH, D’Agostino RB, Wilson PW, Wolf PA. Plasma homocysteine as a risk factor for dementia and Alzheimer’s disease. N Engl J Med 2002; 346(7): 476-483
  7. Corrada M.M, Kawas C.H, Hallfrisch J, Muller D, Brookmeyer R. Reduced risk of Alzheimer’s disease with high folate intake: The Baltimore Longitudinal Study of Aging. Alzheimer’s Dement 2005; 1(1): 11-18
  8. Qin B, Xun P, Jacobs DR, Zhu N, Daviglus ML, Reis JP, Steffen LM, Horn LV, Sidney S, He K. Intake of niacin, folate, vitamin B-6, and vitamin B-12 through young adulthood and cognitive function in midlife: The Coronary Artery Risk Development in Young Adults (CARDIA) study. Am J Clin Nutr 2017; 106(4): 1032-1040
  9. Xiu L, Lee M, Wahlqvist ML, Chen RC, Huang Y, Chen K, Li D. Low and high homocysteine are associated with mortality independent of B group vitamins but interactive with cognitive status in a free-living elderly cohort. Nutr Res 2012; 32(12): 928-939
  10. Ağadayı, E. (2019). Vitamin B12 Kullanımı, Zihinsel ve Fiziksel Egzersizlerin İdiyopatik Unutkanlık Üzerine Etkisi (Tıpta uzmanlık tezi). Erciyes Üniversitesi Sağlık Bilimleri Enstitüsü, Kayseri. Erişim adresi: https://avesis.erciyes.edu. tr/yonetilen-tez/391ecc58-2937-4675-98bd-8a6b082421c4/ vitamin-b12-kullanimi-zihinsel-ve-fiziksel-egzersizlerin- idiyopatik-unutkanlik-uzerine-etkisi 11. van der Zwaluw NL, Dhonukshe-Rutten RA, van Wijngaarden JP, Brouwer-Brolsma EM, van de Rest O, In ‘t Veld PH, Enneman AW, van Dijk SC, Ham AC, Swart KM, van der Velde N, van Schoor NM, van der Cammen TJ, Uitterlinden AG, Lips P, Kessels RP, de Groot LC. Results of 2-year vitamin B treatment on cognitive performance: Secondary data from an