SavedAdd your journal

Journals / Bakırköy Tıp Dergisi / 2019 / Cilt: 15 - Sayı: 3

Serum Fetuin-A Level is Not Correlated with Subclinical Atherosclerosis in Patients with Amyloid A Amyloidosis

Amyloid A Amiloidozlu Hastalarda Serum Fetuin-A Seviyesi Subklinik Ateroskleroz ile İlişkili Değildir

Sebahat ALIŞIR ECDER
Ali BAKAN
Pages
280–286
Publication Date
2022-10-11
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

We also investigated the association between carotid IMT and SF-A levels in patients with AA amyloidosis.Results: We determined a significant increase in carotid IMT among patients with AA amyloidosis compared to healthy controls (p

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: Amyloidosis is the build-up of amyloid fibrils in tissues, which eventually leads to various local and systemic problems.
📊
Key Findings & Data:Data from cohort studies show that decreased serum fetuin-A (SF-A) levels in the serum are associated with morbidity and mortality in patients with end-stage kidney disease.
💡
Conclusion & Impact:We also investigated the association between carotid IMT and SF-A levels in patients with AA amyloidosis.Results: We determined a significant increase in carotid IMT among patients with AA amyloidosis compared to healthy controls (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: Amyloidosis is the build-up of amyloid fibrils in tissues, which eventually leads to various local and systemic problems. Amyloid A amyloidosis (AA amyloidosis) is the most frequent type of systemic amyloidoses. Data from cohort studies show that decreased serum fetuin-A (SF-A) levels in the serum are associated with morbidity and mortality in patients with end-stage kidney disease. Our aim was to investigate whether elevated SF-A levels were associated with common carotid intima-media thickness (IMT) in patients with AA amyloidosis.Methods: We recruited 63 patients with AA amyloidosis and 29 age-matched healthy controls. Demographic data, biochemical parameters, SF-A and carotid IMT values between two groups were compared. We also investigated the association between carotid IMT and SF-A levels in patients with AA amyloidosis.Results: We determined a significant increase in carotid IMT among patients with AA amyloidosis compared to healthy controls (p

Özet

Amaç: Amiloidoz amyloid fibrillerin dokularda birikmesi ile oluşur, çeşitli lokal ve sistemik semptomların oluşmasına neden olur. Amyloid A amyloidozis (AA amyloidozis) sistemik amiyloidozun en sık görülen tipidir. Çalışmalar, azalmış serum fetuin-A (SF-A) seviyesi son dönem böbrek hastalarında artmış morbitite ve mortaliteyle birlikte olduğunu göstermiştir. Amacımız AA amiloidozlu hastalarda yüksek SF-A düzeylerinin ortak karotis intima-media kalınlığı (IMT) ile ilişkili olup olmadığını araştırmaktı. Yöntemler: Çalışmaya 63 AA amiloidozlu olgu ve 29 sağlıklı kontrol dahil ettik. İki grubun demografik verilerini, biyokimasal parametrelerini, SF-A seviyelerini ve karotis IMT değerlerini karşılaştırdık. Aynı zamanda AA amiloidozlu hastalarda karotis intima-media kalınlığı ile SF-A düzeyleri arasındaki ilişkiyi araştırdık. Bulgular: Kontrol grubu ile karşılaştırıldığında AA amiloidozlu hastalarda karotis IMT’nin anlamlı derecede artığını tespit ettik(p

🔖

Cite This Article

ECDER, S. A., BAKAN, A. (2022). Serum Fetuin-A Level is Not Correlated with Subclinical Atherosclerosis in Patients with Amyloid A Amyloidosis. Bakırköy Tıp Dergisi, Cilt: 15 - Sayı: 3, 280–286. https://ajindex.com/articles/460066

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (12)

  1. Ueno T, Takeda K, Nagata M. Remission of proteinuria and preservation of renal function in patients with renal AA amyloidosis secondary to rheumatoid arthritis. Nephrol Dial Transplant 2012;27:633-9.
  2. Laurent S, Cockcroft J, Van Bortel L, Boutouyrie P, Giannattasio C, Hayoz D, et al. Expert consensus document on arterial stiffness: methodological issues and clinical applications. Eur Heart J 2006;27:2588-605.
  3. Boutouyrie P, Tropeano AI, Asmar R, Gautier I, Benetos A, Lacolley P, et al. Aortic stiffness is an independent predictor of primary coronary events in hypertensive patients: a longitudinal study. Hypertension 2002;39:10-5.
  4. Lorenz MW, Markus HS, Bots ML, Rosvall M, Sitzer M. Prediction of clinical cardiovascular events with carotid intima-media thickness: a systematic review and meta-analysis. Circulation 2007;115:459-67.
  5. Salonen JT, Salonen R. Ultrasound B-mode imaging in observational studies of atherosclerotic progression. Circulation 1993;87(3 Suppl):II56-65. Bots ML, Hoes AW, Koudstaal PJ, Hofman A, Grobbee DE. Common carotid intima-media thickness and risk of stroke and myocardial infarction: the Rotterdam Study. Circulation 1997;96:1432-7.
  6. Jahnen-Dechent W, Heiss A, Schafer C, Ketteler M. Fetuin-A regulation of calcified matrix metabolism. Circ Res 2011;108:1494-509.
  7. Schafer C, Heiss A, Schwarz A, Westenfeld R, Ketteler M, Floege J, et al. The serum protein alpha 2-Heremans-Schmid glycoprotein/ fetuin-A is a systemically acting inhibitor of ectopic calcification. J Clin Invest 2003;112:357-66.
  8. Wang H, Sama AE. Anti-inflammatory role of fetuin-A in injury and infection. Curr Mol Med 2012;12:625-33. Roos M, von Eynatten M, Heemann U, Rothenbacher D, Brenner H, Breitling LP. Serum fetuin-A, cardiovascular risk factors, and six-year follow-up outcome in patients with coronary heart disease. Am J Cardiol 2010;105:1666-72.
  9. Ix JH, Chertow GM, Shlipak MG, Brandenburg VM, Ketteler M, Whooley MA. Fetuin-A and kidney function in persons with coronary artery disease--data from the Heart and Soul Study. Nephrol Dial Transplant 2006;21:2144-51.
  10. Levey AS, Stevens LA, Schmid CH, Zhang YL, Castro AF, 3rd, Feldman HI, et al. A new equation to estimate glomerular filtration rate. Ann Intern Med 2009;150:604-12.
  11. Pignoli P, Tremoli E, Poli A, Oreste P, Paoletti R. Intimal plus medial thickness of the arterial wall: a direct measurement with ultrasound imaging. Circulation 1986;74:1399-406.
  12. Roos M, Lutz J, Salmhofer H, Luppa P, Knauss A, Braun S, et al. Relation betw