Journals / Bakırköy Tıp Dergisi / 2021 / Cilt: 17 - Sayı: 3

Management of Phyllodes Tumors of the Breast: Our Clinical Experience

Memenin Filloid Tümörlerinin Yönetimi ve Klinik Deneyimlerimiz

Pages
203–208
Publication Date
2022-10-11
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Extensive analysis of phyllodes tumors is still lacking, and more studies are necessary to understand the behavior of this rare breast tumor.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: This study aimed to examine the demographic features, clinicopathological findings, follow-up results, and treatment methods of patients treated for phyllodes tumors of the breast in light of the literature.
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Key Findings & Data:Methods: All patients with benign, borderline, or malignant phyllodes tumors admitted to our hospital between 2013 and 2020 were retrospectively analyzed.
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Conclusion & Impact:Extensive analysis of phyllodes tumors is still lacking, and more studies are necessary to understand the behavior of this rare breast tumor.
🔬Design:Research Article
📍Scope:2013 Verileri
⚙️Variables:Domain Parameters

Abstract

Objective: This study aimed to examine the demographic features, clinicopathological findings, follow-up results, and treatment methods of patients treated for phyllodes tumors of the breast in light of the literature. Methods: All patients with benign, borderline, or malignant phyllodes tumors admitted to our hospital between 2013 and 2020 were retrospectively analyzed. Results: The study included a total of 14 patients with phyllodes tumors of the breast on histopathological examinations, wherein 6 were benign (42.9%), 3 were borderline (21.4%), and 5 were malignant (35.7%). The mean age was similar in the groups (p=0.654). Tumors were more frequently located in the right breast; however, no difference was found between the groups in terms of laterality (p=0.514). The tumor diameter was significantly smaller in benign phyllodes (benign: 32 mm, borderline: 72 mm, and malignant: 80 mm, p=0.036). Benign phyllodes were more frequently breast imaging-reporting and data system (BI-RADS) 3 and malignant phyllodes were BI-RADS 5; however, the difference was not significant. A core needle biopsy was performed in eight patients as the most common biopsy method (57.1%). The most common surgical procedure was segmental mastectomy (71.4%). Re-excision was performed in three patients due to the surgical margin positivity or closeness. One patient received chemotherapy and radiotherapy (RT) and 4 patients only received RT. The mean follow-up time was 53.8±25.4 months (13-96 months). Local recurrences occurred in two patients during the follow-up. Distant metastases or deaths were not observed. Conclusion: Phyllodes tumors are rare, mixed-type breast tumors. Histopathological features and classification guide the management plan. Extensive analysis of phyllodes tumors is still lacking, and more studies are necessary to understand the behavior of this rare breast tumor.

Özet

Amaç: Filloid meme tümörü tedavisi gören hastalarımızın demografik özelliklerini, klinikopatolojik bulgularını, takip sonuçlarını ve tedavi yöntemlerini literatür ışığında incelemeyi amaçladık. Gereç ve Yöntem: Kurumumuza 2013-2020 yılları arasında başvuran benign, borderline veya malign filloid tümörlü tüm hastalar retrospektif olarak incelendi. Bulgular: Histopatolojik olarak 6 benign (%42,9), 3 borderline (%21,4) ve 5 malign filloid tümör (%35,7) olmak üzere toplam 14 hasta dahil edilebildi. Ortalama yaş gruplarda benzerdi (p=0,654). Sağ meme daha sık lokalize olmasına rağmen lokalizasyon açısından gruplar arasında farklılık yoktu (p=0,514). Benign grupta tümör çapı düşüktü (benign: 32 mm, borderline: 72 mm, malign: 80 mm, p=0,036). Benign grupta BIRADS 3 ve malign grupta BIRADS 5 ağırlık olmasına rağmen, istatistiksel olarak fark yoktu. En yaygın biyopsi yöntemi olarak 8 (%57,1) hastaya tru-cut biyopsi yapıldı. En yaygın cerrahi prosedür segmental mastektomiydi (%71,4). Üç hastaya cerrahi sınırın pozitifliği veya yakınlığı nedeniyle yeniden eksizyon yapıldı. Bir hasta kemoterapi ve radyoterapi aldı ve 4 hasta radyoterapi aldı. Ortalama takip süresi 53,8±25,4 aydı (13-96). Takip sırasında 2 hastada lokal nüks meydana geldi. Uzak metastaz veya ölüm yoktu.Sonuç: Phyllodes tümörler nadir görülen, mikst tip meme tümörleridir. Yönetim planına histopatolojik özellikler ve sınıflandırma rehberlik eder. Filloid tümörlerin kapsamlı analizi hala eksiktir ve bu nadir meme tümörünün davranışını anlamak için daha fazla çalışmaya ihtiyaç vardır.

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Cite This Article

PARLAKGÜMÜŞ, A., TAŞ, Z. A., TOPAL, U., ERDOĞAN, O., İRKORUCU, O. (2022). Management of Phyllodes Tumors of the Breast: Our Clinical Experience. Bakırköy Tıp Dergisi, Cilt: 17 - Sayı: 3, 203–208. https://ajindex.com/articles/459959

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