SavedAdd your journal

Journals / Atatürk Üniversitesi Veteriner Bilimleri Dergisi / 2018 / Cilt: 13 - Sayı: 2

Protective Effects of Naringin on Liver Enzymes (AST, ALT, ALP) and Histopathology in Cyclophosphamide-Induced Rats

Cyclophosphamide İle İndüklenmiş Ratlarda Karaciğer Enzimleri (AST, ALT, ALP) ve Histopatolojisi Üzerine Naringin’in Protektif Etkileri

Leyla MİS
Ali ÇINAR
Fikret ÇELEBİ
Emin ŞENGÜL
Gözde YAMAN BÜLBÜL
Serkan YILDIRIM
Pages
182–190
Publication Date
2022-10-11
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

According to the values obtained from the control group, there is an increase of P

📌 3 Key Takeaways

🎯
Objective & Hypothesis:In this study, it is aimed to investigate the protective effects of Naringin on liver enzymes (Aspartate Aminotransferase (AST), Alanine Aminotransferase (ALT), Alkaline Phosphatase (ALP) and histopathology in CYP-induced rats.
📊
Key Findings & Data:In our study, forty male adult Sprague Dawley rat weighing approximately 200-250 g were used and 5 gropus formed.
💡
Conclusion & Impact:According to the values obtained from the control group, there is an increase of P
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

In this study, it is aimed to investigate the protective effects of Naringin on liver enzymes (Aspartate Aminotransferase (AST), Alanine Aminotransferase (ALT), Alkaline Phosphatase (ALP) and histopathology in CYP-induced rats. In our study, forty male adult Sprague Dawley rat weighing approximately 200-250 g were used and 5 gropus formed. Analyzes of liver enzymes were done in auto analyzer and spectrophotometer. The liver tissue samples stained with hematoxylin eosin were examined by light microscopy. CYP was found to cause hapatotoxicity and showed increased liver enzymes in rats. AST, ALT and ALP values were 58±11, 32±8, 38±6 in the control group; 237±42, 168±44, 74±11 in the CYP group; 223±33, 158±42, 62±9 in the Naringin 50+CYP group; 117±25, 107±24, 48±8 in Naringin 100+CYP group; 54±9, 31±7, 36±6 in the group of Naringin 100 were found respectively. According to the values obtained from the control group, there is an increase of P

Özet

Bu çalışmada Cyclophosphamide (CYP) uygulaması yapılan ratlarda karaciğer enzimleri (Aspartat aminotransferaz (AST),Alanin aminotransferaz (ALT), Alkalen fosfataz (ALP) ve histopatolojisi üzerine Naringin’in protektif etkilerinin araştırılmasıamaçlanmaktadır. Araştırmamızda yaklaşık 200-250 g ağırlığında, 40 adet erkek erişkin Sprague Dawley ırkı rat kullanıldı ve 5grup oluşturuldu. Karaciğer enzimlerinin analizleri otoanalizörde ve spektrofotometrede yapıldı. Hematoksilen eosin ileboyanan karaciğer doku örnekleri ışık mikroskobunda incelendi. CYP’nin ratlarda hepatotoksiteye yol açtığı ve karaciğerenzimlerini artırdığı görüldü. AST, ALT ve ALP değerleri Kontrol grubunda 58±11, 32±8, 38±6; CYP grubunda 237±42, 168±44,74±11; Naringin 50+CYP grubunda 223±33, 158±42, 62±9; Naringin 100+CYP grubunda 117±25, 107±24, 48±8; Naringin 100grubunda ise 54±9, 31±7, 36±6 sırasıyla olarak bulundu. Kontrol grubundan elde edilen değerlere göre CYP verilen gruplardaki AST, ALT ve ALP değerlerinin tamamında P

🔖

Cite This Article

MİS, L., ÇINAR, A., ÇELEBİ, F., ŞENGÜL, E., BÜLBÜL, G. Y., YILDIRIM, S. (2022). Protective Effects of Naringin on Liver Enzymes (AST, ALT, ALP) and Histopathology in Cyclophosphamide-Induced Rats. Atatürk Üniversitesi Veteriner Bilimleri Dergisi, Cilt: 13 - Sayı: 2, 182–190. https://ajindex.com/articles/455803

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (12)

  1. Ernest E., Cassiletth B., 1998. The prevealence of complementary. Alternative medicine in cancer. Cancer, 83, 777-782
  2. Akay H., Akay T., Secilmis S., Kocak Z., Donderici O., 2006. Hepatotoxcity after low-dose cyclophosphamide. South Med J, 99, 1399-1401
  3. DeSouza L., Shen Y., Bognar AL., 2000. Disruption of cytoplasmic and mitochondrial folylpolyglutamate synthetase activity in Saccharomyces cerevisiae. Arch Biochem Biophys, 376, 299-312
  4. Meirow D., Assad G., Dor J., Rabinovici J., 2004. The GnRH antagonist cetrorelix reduces cyclophosphamide-induced ovarian follicular destruction in mice. Hum Reprod, 19, 1294-1299
  5. Thatcher RW., Walker RA., Gerson I., Geisler FH., 1989, EEG discriminant analyses of mild head trauma. EEG Clin Neurophysiol, 73, 94-106
  6. Muratori L., Ferrari R., Muratori P., Granito A., Bianchi FB., 2005. Acute icteric hepatitis induced by a short course of low-dose cyclophosphamide in a patient with lupus nephritis. Dig Dis Sci, 50, 2364-2365
  7. Webb H., Jaureguiberry G., Dufek S., Tullus K., Bockenhauer D., 2016. Cyclophosphamide and rituximab in frequently relapsing/steroiddependent nephrotic syndrome. Pediatr Nephrol, 31, 589-594
  8. Doğan Z., Kocahan S., Erdemli E., Kose E., Yılmaz I., Ekincioğlu Z., Ekinci N., Turkoz Y., 2015. Effect of chemotherapy exposure prior to pregnancy on fetal brain tissue and the potential protective role of quercetin. Cytotechnology, 67, 1031-1038
  9. Nafees S., Rashid S., Ali N., Hasan SK., Sultana S., 2015. Rutin ameliorates cyclophosphamide induced oxidative stress and inflammation in Wistar rats: role of NFKB/MAPK pathway. Chem Biol Interact, 231, 98-107
  10. Bacanlı M., Başaran AA., Başaran N., 2015. The antioxidant and antigenotoxic properties of citrus phenolics limonene and naringin. Food Chem Toxicol, 81, 160-170. 11.Galati EM., Monforte MT., d'Aquino A., Miceli N., Di Mauro D., Sanogo R., 1998. Effects of naringin on experimental ulcer in rats. Phytomedicine, 5, 361-366
  11. Xie Y., Yang W., Tang F., Chen X., Ren L., 2015. Antibacterial activities of flavonoids: structureactivity relationship and mechanism. Curr Med Chem, 22, 132-149
  12. Liu L., Zuo Z., Lu S., Liu A., Liu X., 2017. Naringin attenuates diabetic retinopathy by inhibiting inflammation, oxidative stress and NF-KB activation in vivo and in vitro. IJBMS, 20, 813. 14.Ueng YF., Chang YL., Oda Y., Park SS., Liao JF., Lin MF., Chen CF., 1999. In vitro and in vivo effects of naringin on cytochrome P450-dependent monooxygenas