Journals / Atatürk Üniversitesi Veteriner Bilimleri Dergisi / 2019 / Cilt: 14 - Sayı: 3

Application of Xanten and Its Derivatives in Human and Veterinary Medicine

Xanten ve Türevlerinin İnsan ve Veteriner Hekimlikte Kullanımı

Pages
335–342
Publication Date
2022-10-11
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In this review the most importantactivity of xanthen derivatives such as antibacterial, antifungal, antihelmintic, antiprotozoal, anticancerogenic andantidiabetic activity and mechanism of their action are presented.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Xanthene derivatives represent cyclic, organic compounds that can be natural, semi-synthetic and synthetic origin.These compounds become very interesting because of various pharmacological activities such as antibacterial, antiviral andanti-inflammatory properties.
📊
Key Findings & Data:Furthermore, they have been utilized as antagonists for drug-resistant leukemia lines and inphotodynamic therapy.
💡
Conclusion & Impact:In this review the most importantactivity of xanthen derivatives such as antibacterial, antifungal, antihelmintic, antiprotozoal, anticancerogenic andantidiabetic activity and mechanism of their action are presented.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Xanthene derivatives represent cyclic, organic compounds that can be natural, semi-synthetic and synthetic origin.These compounds become very interesting because of various pharmacological activities such as antibacterial, antiviral andanti-inflammatory properties. Furthermore, they have been utilized as antagonists for drug-resistant leukemia lines and inphotodynamic therapy. They are also applied as dyes in laser technology and pH sensitive fluorescent materials forvisualization of biomolecules. Because of new diseases in veterinary medicine, application of these compounds can be veryuseful and literature describes activity of similar compunds in veterinary research field. In this review the most importantactivity of xanthen derivatives such as antibacterial, antifungal, antihelmintic, antiprotozoal, anticancerogenic andantidiabetic activity and mechanism of their action are presented.

Özet

Ksanten türevleri, doğal, yarı sentetik ve sentetik kökenli olabilen siklik, organik bileşikleri temsil eder. Bu bileşikler, antibakteriyel, antiviral ve antienflamatuar özellikler gibi çeşitli farmakolojik aktiviteler nedeniyle dikkat çekmektedirler. Ayrıca, ilaca dirençli lösemi hatları için ve fotodinamik tedavide antagonistler olarak kullanılmaktadırlar. Ayrıca lazer teknolojisinde boyalar ve biyomoleküllerin görselleştirilmesi için pH'a duyarlı floresan malzemeler olarak uygulanırlar. Veteriner hekimlik alanında yeni hastalıklar nedeniyle, bu bileşiklerin uygulanması çok faydalı olabilir ve literatürde Veteriner araştırma alanındaki benzer bileşiklerin aktivitesi açıklanmaktadır. Bu derlemede ksanten türevlerinin antibakteriyel, antifungal, antihelmintik, antiprotozoal, antikanserojenik ve antidiyabetik aktivite gibi en önemli aktiviteleri ve etki mekanizmaları sunulmuştur.

🔖

Cite This Article

KATICA, M., SMAJOVIC, A., ZAVRŠNIK, D., ČAKLOVICA, K. (2022). Application of Xanten and Its Derivatives in Human and Veterinary Medicine. Atatürk Üniversitesi Veteriner Bilimleri Dergisi, Cilt: 14 - Sayı: 3, 335–342. https://ajindex.com/articles/455741

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (12)

  1. Cai K., Wang Y., Guo Z., Xu X., Li H., Zhang Q., 2018. Clinical characteristics and antimicrobial resistance of pneumococcal isolates of pediatric invasive pneumococcal disease in China. Infect Drug Resist, 11, 2461-2469
  2. Fotie J., Bohle DS., 2006. Pharmacological and biological activities of xanthones. Anti-Infect Agent Med Chem, 5, 15-31
  3. Negi JS., Bisht VK., Singh P., Rawat MSM., Joshi GP., 2013. Naturally occurring canthones: chemistry and biology. J App Chem, 1, 1-9
  4. Marona H., Szkaradek N., Karczewska E., Trojanowska D., Budak A., Bober P., Przepiorka W., Cegla M., Szneler E., 2009. Antifungal and Antibacterial Activity of the Newly Synthesized 2-Xanthone Derivates. Arch Pharm (Weinheim), 342, 9-18
  5. Garcia D., Escalante M., Delgado R., Ubeira FM., Leiro J., 2003. Anthelminthic and antiallergic activities of Mangifera indica L. stem bark components Vimang and mangiferin. Phytother Res, 17, 1203-1208
  6. Veljovic E., Spirtovic-Halilovic S., Muratovic S., Valek Zulj L., Roca S., Trifunovic S., Osmanovic A., Davorka Z., 2015. 9-Aryl substituted hydroxylated xanthen-3-ones: Synthesis, structure and antioxidant potency evaluation. Croat Chem Acta, 88, 121-127
  7. Mariano LN., Da Silva LM., De Souza P., Boeing T., Somensi LB., Bonomini TJ., Delle Monache F., Cechinel Filho V., de Andrade SF., Niero R., 2016. Gastroprotective xanthones isolated from Garcinia achachairu: Study on mucosal defensive factors and H (+), K(+)-ATPase activity. Chem Biol Interact, 258, 30-39
  8. Irondi EA., Oboh G., Akindahunsi AA., 2016. Antidiabetic effects of Mangifera indica Kernel Flour-supplemented diet in streptozotocininduced type 2 diabetes in rats. Food Sci Nutr, 4, 828-839
  9. Peres V., Nagem TJ., 1997. Naturally occurring, pentaoxygenated, hexaoxygenated and dimeric xanthones: A literature survey. Quimica Nova, 20, 388-397
  10. Veljovic E., Spirtovic-Halilovic S., Muratovic S., Osmanovic A., Haveric S., Haveric A., Hadzic M., Salihovic M., Malenica M., Sapcanin A., Zavrsnik D., 2019. Antiproliferative and genotoxic potential of xanthen-3-one derivatives. Acta Pharm, 69, 683-694
  11. Tantapakul C., Maneerat W., Sripisut T., Ritthiwigrom T., Andersen RJ., Cheng P., Cheenpracha S., Raksat A., Laphookhieo S., 2016. New Benzophenones and Xanthones from Cratoxylum sumatranum ssp. neriifolium and Their Antibacterial and Antioxidant Activities. J Agric Food Chem, 64, 8755-8762
  12. Stoilova I., Gargova S., Stoyanova A., Ho I., 2005. Antimicrobial and antioxidant a