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Journals / Acta Medica Alanya / 2017 / Cilt: 1 - Sayı: 3

Migraine and peripheral inflammation

Migren ve periferik inflamasyon

Aynur YILMAZ AVCI
Oktay AKALİN
Pages
127–134
Publication Date
2017-12-15
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

Conclusion: Increased levels of peripheral inflammation may occur in patients with migraine and may be involved in the pathogenesis of migraine.

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: Migraine is a common headache disorder that may be associated with inflammation and vascular diseases.
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Key Findings & Data:We evaluated C-reactive protein and the number of immune cells in the peripheral blood of young adult patients with migraine.Patients and Methods: This case–control study included 520 subjects: 260 patients with migraine (without aura, 169 patients; with aura, 91 patients) and 260 healthy control subjects (age range, 18–50 years).
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Conclusion & Impact:Conclusion: Increased levels of peripheral inflammation may occur in patients with migraine and may be involved in the pathogenesis of migraine.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Tam kan sayımı · C-reaktif protein · başağrısı

Abstract

Aim: Migraine is a common headache disorder that may be associated with inflammation and vascular diseases. We evaluated C-reactive protein and the number of immune cells in the peripheral blood of young adult patients with migraine.Patients and Methods: This case–control study included 520 subjects: 260 patients with migraine (without aura, 169 patients; with aura, 91 patients) and 260 healthy control subjects (age range, 18–50 years). Participants had no known anemia, vascular risk factors, or inflammatory diseases. We evaluated serum C-reactive protein and complete blood count parameters in patients with migraine and control subjects.Results: C-reactive protein level, leukocyte, neutrophillymphocyte, platelet counts and mean platelet volume significantly differed in patients with migraine compared to controls (P<0.001). However, with the exception of C-reactive protein, these parameters were similar in migraine with and without aura. Logistic regression analysis showed that migraine was significantly associated with C-reactive protein level (odds ratio [OR], 2.36; 95% confidence interval [CI], 1.73–3.23; P<0.001), MPV (OR, 2.32; 95% CI, 1.78–3.0; P<0.001), and leukocyte count (OR, 1.61; 95% CI, 1.32–1.94;). Conclusion: Increased levels of peripheral inflammation may occur in patients with migraine and may be involved in the pathogenesis of migraine.

Özet

Amaç: Migren inflamasyon ve vasküler hastalıklar ile ilişkili olabilen yaygın bir baş ağrısı türüdür. Biz genç erişkin migren hastalarında C-reaktif protein ve periferik kandaki bağışık hücre sayısını değerlendirdik.Hastalar ve Yöntem: Bu olgu-kontrol çalışması, 260 migren hastası (aurasız, 169 olgu, auralı, 91 olgu) ve 260 sağlıklı kontrol katılımcı (yaş aralığı, 18-50 yıl) olmak üzere 520 kişiyi içermektedir. Katılımcıların hiçbirinde bilinen bir anemi, vasküler risk faktörü veya inflamatuar hastalık yoktu. Migren ve kontrol olgularında serum C-reaktif protein ve tam kan sayımı parametrelerini değerlendirdik.Bulgular: C-reaktif protein, lökosit, nötrofil, lenfosit, trombosit sayıları ve ortalama trombosit hacmi migren hastalarında kontrol grubuna (P <0.001) oranla anlamlı olarak farklıydı. Ancak bu parametreler, C-reaktif protein hariç, auralı ve aurasız migrenlerde benzerdi. Lojistik regresyon analizinde migren hastalığı C-reaktif protein seviyesi (OR, 2.36; 95% CI, 1.73 ile 3.23; P< 0.001), ortalama trombosit hacmi (odds ratio [OR], 2.32; 95% confidence interval [CI], 1.78 - 3.0; P<0.001), ve lökosit sayısı (OR, 1.61; 95% CI, 1.32 - 1.94; P< 0.001) ile anlamlı olarak ilişkiliydi. Sonuç: Periferik inflamasyonun artmış seviyeleri migren hastalarında ortaya çıkabilir ve migren patogenezinde rol oynayabilir.

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Cite This Article

AVCI, A. Y., AKALİN, O. (2017). Migraine and peripheral inflammation. Acta Medica Alanya, Cilt: 1 - Sayı: 3, 127–134. https://ajindex.com/articles/449932

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References (16)

  1. Lipton RB, Stewart WF, Diamond S, Diamond ML, Reed M. Prevalence and burden of migraine in the United States: data from the American Migraine Study II. Headache 2001;41(7):646–57
  2. Waeber C, Moskowitz MA. Migraine as an inflammatory disorder. Neurology. 2005;64(10 Suppl 2):S9–S15
  3. Bolay H, Reuter U, Dunn AK, Huang Z, Boas DA, Moskowitz MA. Intrinsic brain activity triggers trigeminal meningeal afferents in migraine model. Nat Med. 2002;8(2):136–42
  4. Moskowitz MA. The neurobiology of vascular head pain. Neurology. 1984;16(2):157–168
  5. Markowitz S, Saito K, Moskowitz MA. Neurogenically mediated leakage of plasma protein occurs from blood vessels in dura mater but not brain. J Neurosci. 1987;7(12):4129–36
  6. Goadsby PJ, Edvinsson L, Ekman R. Vasoactive peptide release in the extrecerebral circulation of humans during migraine headache. Ann Neurol. 1990;28(2):183–7
  7. Kemper RH, Meijer WJ, Korf J, Ter Horst GJ. Migraine and function of the immune system: a meta-analysis of clinical literature published between 1966 and 1999. Cephalalgia. 2001;21(5):549–57
  8. Sarchielli P, Alberti A, Baldi A, Coppola F, Rossi C, Pierguidi L, et al. Proinflammatory cytokines, adhesion molecules, and lymphocyte integrin expression in the internal jugular blood of migraine patients without aura assessed ictally. Headache. 2006;46(2):200–7
  9. Bassuk SS, Rifai N, Ridker PM. High-sensitivity C-reactive protein: clinical importance. Curr Probl Cardiol. 2004;29(8):439–93
  10. Emerging Risk Factors Collaboration, Kaptoge S, Di Angelantonio E, Pennells L, Wood AM, White IR, Gao P, et al. C-reactive protein, fibrinogen, and cardiovascular disease prediction. N Engl J Med. 2012;367(14):1310–20
  11. Vanmolkot FH, de Hoon JN. Increased C-reactive protein in young adult patients with migraine. Cephalalgia. 2007;27(7):843–846
  12. Yilmaz Avci A, Lakadamyali H, Arikan S, Benli US, Kilinc M. High sensitivity C-reactive protein and cerebral white matter hyperintensities on magnetic resonance imaging in migraine patients. J Headache Pain. 2015;16:9
  13. Phillipson M, Kubes P. The neutrophil in vascular inflammation. Nat Med. 2011;17(11):1381–90
  14. Soehlein O. Multiple roles for neutophils in atherosclerosis. Circ Res. 2012;110(6):875–88
  15. Libby P, Nahrendorf M, Swirski FK. Leukocytes link local and systemic inflammation in ischemic cardiovascular disease: an expanded “Cardiovascular Continuum.” J Am Coll Cardiol. 2016;67(9):1091–103
  16. Lahoute C, Herbin O, Mallat Z, Tedgui A