Relationship between serum neuron specific enolase values and prognosis in acute stroke

Among the compared values, NSE levels were found to be significantly high (p = 0.04, p < 0.05) only in the group whose initial Glasgow Coma Scale scores were poor.

📌 3 Key Takeaways

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Objective & Hypothesis:In acute stroke, one of the non-invasive techniques utilized to determine neuronal injury and functional prognosis is the measurement of serum Neuron Specific Enolase (NSE) levels. in this study, 30 patients with cerebrovascular disease (15 ischemic and 15 hemorrhagic insults) and 15 contol patients which had similar age and gender were studied.

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Key Findings & Data:NSE levels were measured in acute phase (first 48(12 hours) and lesion types, localization, initial score of Glasgow Coma Scale, initial blood glucose level, age and a Rankin Score at the tenth day were determined.

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Conclusion & Impact:Among the compared values, NSE levels were found to be significantly high (p = 0.04, p < 0.05) only in the group whose initial Glasgow Coma Scale scores were poor.

🔬Design:Research Article

📍Scope:Comprehensive Sample

⚙️Variables:İnme · Seyir · Fosfopirüvat hidrataz

Abstract

In acute stroke, one of the non-invasive techniques utilized to determine neuronal injury and functional prognosis is the measurement of serum Neuron Specific Enolase (NSE) levels. in this study, 30 patients with cerebrovascular disease (15 ischemic and 15 hemorrhagic insults) and 15 contol patients which had similar age and gender were studied. NSE levels were measured in acute phase (first 48(12 hours) and lesion types, localization, initial score of Glasgow Coma Scale, initial blood glucose level, age and a Rankin Score at the tenth day were determined. Althought the NSE levels were found to be higher in ischemic and hemorrhagic groups than the control group, the results were not statistically significant. Among the compared values, NSE levels were found to be significantly high (p = 0.04, p < 0.05) only in the group whose initial Glasgow Coma Scale scores were poor.

Özet

Akut strokta, nöronal hasarı ve fonksiyonel prognozu belirlemek için yapılan noninvazif tetkiklerden biri de serum Nöron Spesifik Enolaze (NSE) değerlerinin ölçümüdür. Bu çalışmada, serebrovasküler hastalığı olan 30 olgu (15'i iskemik ve 15'i hemorajik vaka) ve benzer yaş ve cinsiyete sahip 15 kontrol hastası çalışılmıştır. NSE seviyeleri akut fazda (ilk 48±12 saat) ölçülmüştür ve lezyon tipi, lokalizasyonu, Glaskow Koma Skalasının (GKS) başlangıç skoru, ilk kan glukoz değerleri, yaş ve onuncu gündeki Rankin Skoru belirlenmiştir. Sonuçta serum NSE düzeyleri, iskemik ve hemorajik stroklu gruplarda, kontrol grubuna göre daha yüksek bulunmuştur. Fakat sonuçlar istatistiksel olarak anlamlı değildi. Karşılaştırılan değerler arasında NSE düzeyleri başlangıç GKS'leri düşük olan grupta anlamlı derecede daha yüksek bulunmuştur (p = 0.04, p<0.05).

Keywords

İnme Seyir Fosfopirüvat hidrataz Serebrovasküler olay Stroke Prognosis Phosphopyruvate Hydratase Cerebrovascular Accident

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Cite This Article

AVCI, A. Y., YÜKSEL, M., AYDIN, N., ERDOĞAN, M. S., ÇİFTÇİ, Ş., UTKU, U. (2001). Relationship between serum neuron specific enolase values and prognosis in acute stroke. Türk Beyin Damar Hastalıkları Dergisi, Cilt: 7 - Sayı: 3, 147–149. https://ajindex.com/articles/402913

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