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Journals / Arşiv Kaynak Tarama Dergisi / 2017 / Cilt: 26 - Sayı: 1

Relationship between Epigenetics and Circadian Clock

Sirkadiyen Saatin Epigenetikle İlişkisi

Levent KAYRIN
Mustafa Muhlis ALPARSLAN
Umut KÖKBAŞ
Kezban KARTLAŞMIŞ
Başak SANNA
Pages
50–62
Publication Date
2022-10-11
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In this review, some of the circadian genes and regulatory proteins, the current evidence related to the epigenetic modifications that result in circadian disruption and he carcinogenic effects of circadian disruption and its potential role in different human cancers using an epigenetic viewpoint will be reviewed

📌 3 Key Takeaways

🎯
Objective & Hypothesis:The circadian clock controls the daily rhythmicity of the biochemistry, physiology, and behavior of the organisms.
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Key Findings & Data:Disruption of circadian rhythms, affects many biological processes within the body and results in different long-term diseases, such as cancer.
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Conclusion & Impact:In this review, some of the circadian genes and regulatory proteins, the current evidence related to the epigenetic modifications that result in circadian disruption and he carcinogenic effects of circadian disruption and its potential role in different human cancers using an epigenetic viewpoint will be reviewed
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

The circadian clock controls the daily rhythmicity of the biochemistry, physiology, and behavior of the organisms. Disruption of circadian rhythms, affects many biological processes within the body and results in different long-term diseases, such as cancer. Circadian regulatory pathways causes rhythmic epigenetic modifications and the formation of circadian epigenomes. Abnormal epigenetic modifications, such as hypermethylation, may be involved in the transformation of normal cells into cancer cells. In this review, some of the circadian genes and regulatory proteins, the current evidence related to the epigenetic modifications that result in circadian disruption and he carcinogenic effects of circadian disruption and its potential role in different human cancers using an epigenetic viewpoint will be reviewed

Özet

Sirkadiyen saat organizmaların biyokimyalarının, fizyolojilerinin ve davranışlarının günlük ritmlerini kontrol eder. Sirkadiyen ritmin bozulması, kanserler de dahil olmak üzere birçok uzun süreli hastalığı ve vücuttaki biyolojik süreçleri etkilemektedir. Sirkadiyen düzenleyici yollar, sirkadiyen epigenomların oluşumuna ve ritmik epigenetik değişikliklere neden olur. Sirkadiyenin bozulmasından dolayı oluşan hipermetilasyon gibi anormal epigenetik modifikasyonlar, normal hücrelerin kanser hücrelerine dönüşümüne sebep olabilir. Bu derlemede sirkadiyen genler ve düzenleyici proteinler, sirkadiyen saatin bozulması sonucu oluşan epigenetik değişikliklere ilişkin güncel kanıtlar ve sirkadiyen bozulmanın karsinojenik etkileri ve insanlardaki farklı kanserlerdeki potansiyel rolü tartışılacaktır

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Cite This Article

KAYRIN, L., ALPARSLAN, M. M., KÖKBAŞ, U., KARTLAŞMIŞ, K., SANNA, B. (2022). Relationship between Epigenetics and Circadian Clock. Arşiv Kaynak Tarama Dergisi, Cilt: 26 - Sayı: 1, 50–62. https://ajindex.com/articles/449218

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