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Journals / Annals of Medical Research / 2019 / Cilt: 26 - Sayı: 1

Effects of melatonin treatment on the spermatogenesis and serum inflammatory cytokine levels in diabetic rats

Hüseyin Serkan EROL
Merve AYDIN
Didem ONK
Cebrail GÜRSUL
Aliseydi BOZKURT
Mehmet KARABAKAN
Sinem GUMUSTAS
Pages
12–16
Publication Date
2022-10-12
DOI
—
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Spermatogenesis was negatively affected in diabetic rats and significantly improved with melatonin therapy (p

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Objective & Hypothesis:Aim: Diabetes mellitus (DM) is known to have side effects on sexual and reproductive functions in males.
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Key Findings & Data:The aim of current study was to investigate the effect of melatonin treatment on spermatogenesis and serum inflammatory cytokine levels in diabetic rats.Material and Method: Eighteen adult Wistar albino male rats were divided randomly into three groups each containing 6 rats; control group (group 1), diabetic group (group 2), diabetic treated with melatonin group (group 3).
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Conclusion & Impact:Spermatogenesis was negatively affected in diabetic rats and significantly improved with melatonin therapy (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Aim: Diabetes mellitus (DM) is known to have side effects on sexual and reproductive functions in males. The aim of current study was to investigate the effect of melatonin treatment on spermatogenesis and serum inflammatory cytokine levels in diabetic rats.Material and Method: Eighteen adult Wistar albino male rats were divided randomly into three groups each containing 6 rats; control group (group 1), diabetic group (group 2), diabetic treated with melatonin group (group 3). Experimental diabetes was obtained by administrating 50 mg/kg streptozotocin. Melatonin treatment was administered intraperitoneally for 7 days at a dose of 20 mg, daily. Serum levels of interleukin-1 beta (IL-1β), interleukin 6 (IL-6) and tumor necrosis factor-alpha (TNF-α) were assayed. Spermatogenesis was evaluated according to Johnsen score at immunopathological examination.Results: The Johnsen scores in control, diabetic and treatment groups were 9.78, 8.91, and 9.61, respectively. Spermatogenesis was negatively affected in diabetic rats and significantly improved with melatonin therapy (p

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Cite This Article

EROL, H. S., AYDIN, M., ONK, D., GÜRSUL, C., BOZKURT, A., KARABAKAN, M., GUMUSTAS, S. (2022). Effects of melatonin treatment on the spermatogenesis and serum inflammatory cytokine levels in diabetic rats. Annals of Medical Research, Cilt: 26 - Sayı: 1, 12–16. https://ajindex.com/articles/446756

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References (15)

  1. Belotto MF, Magdalon J, Rodrigues HG, et al. Moderate exercise improves leucocyte function and decreases inflammation in diabetes. Clin Exp Immunol 2010;162: 237-43
  2. Coskun O, Ocakci A, Bayraktaroglu T, et al. Exercise training prevents and protects streptozotocin-induced oxidative stress and beta-cell damage in rat pancreas. Tohoku J Exp Med 2004;203:145-54
  3. Kim ST, Moley KH. Paternal effect on embryo quality in diabetic mice is related to poor sperm quality and associated with decreased glucose transporter expression. Reproduction 2008;136:313-22
  4. Scarano WR, Messias AG, Oliva SU, et al. Sexual behaviour, sperm quantity and quality after short-therm streptozotocin-induced hyperglycaemia in rats. Int J Androl 2006;29: 482-8
  5. Mangoli E, Talebi AR, Anvari M, et al. Effects of experimentally-induced diabetes on sperm parameters and chromatin quality in mice. Iran J Reprod Med 2013;11:53-60
  6. Meyer K, Deutscher J, Anil M, et al. Serum androgen levels in adolescents with type 1 diabetes: relationship to pubertal stage and metabolic control. J Endocrinol Invest 2000;23:362-8
  7. Guneli E, Tugyan K, Ozturk H, et al. Effect of melatonin on testicular damage in streptozotocin-induced diabetes rats. Eur Surg Res 2008;40: 354-60
  8. Cai L, Chen S, Evans T, et al. Apoptotic germ-cell death and testicular damage in experimental diabetes: prevention by endothelin antagonism. Urol Res 2000;28:342-7
  9. Dandona P, Aljada A, Chaudhuri A, et al. Metabolic syndrome: a comprehensive perpective based on interactions between obesity, diabetes, and inflammation. Circulation 2005;111:1448-54
  10. Khaki A, Nouri M, Fathiazad F, Protective effects of quercetin on spermatogenesis in streptozotocin-induced diabetic rat. J Med Plants Res 2009;8:57-64
  11. Grimaldi P, Di Giacomo D, Geremia R. The endocannabinoid system and spermatogenesis. Front Endocrinol (Lausanne) 2013;4:192
  12. Huleihel M, Lunenfeld E. Regulation of spermatogenesis by paracrine/autocrine testicular factors. Asian J Androl 2004;6:259-68
  13. Lysiak JJ. The role of tumor necrosis factor-alpha and interleukin-1 in the mammalian testis and their involvement in testicular torsion and autoimmune orchitis. Reprod Biol Endocrinol 2004;2:9
  14. Lui WY, Lee WM. Molecular mechanisms by which hormones and cytokines regulate cell junction dynamics in the testis. J Mol Endocrinol 2009;43:43-51
  15. Budhwar S, Singh V, Verma P, et al. Fertilization failure and gamete health: Is there a link? Front Biosci (Schol