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Dergiler / Annals of Medical Research / 2019 / Cilt: 26 - Sayı: 1

Effects of melatonin treatment on the spermatogenesis and serum inflammatory cytokine levels in diabetic rats

Hüseyin Serkan EROL
Merve AYDIN
Didem ONK
Cebrail GÜRSUL
Aliseydi BOZKURT
Mehmet KARABAKAN
Sinem GUMUSTAS
Sayfa
12–16
Yayın Tarihi
2022-10-12
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Spermatogenesis was negatively affected in diabetic rats and significantly improved with melatonin therapy (p

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Aim: Diabetes mellitus (DM) is known to have side effects on sexual and reproductive functions in males.
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Temel Bulgular & Veri:The aim of current study was to investigate the effect of melatonin treatment on spermatogenesis and serum inflammatory cytokine levels in diabetic rats.Material and Method: Eighteen adult Wistar albino male rats were divided randomly into three groups each containing 6 rats; control group (group 1), diabetic group (group 2), diabetic treated with melatonin group (group 3).
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Sonuç & Katkı:Spermatogenesis was negatively affected in diabetic rats and significantly improved with melatonin therapy (p
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Abstract

Aim: Diabetes mellitus (DM) is known to have side effects on sexual and reproductive functions in males. The aim of current study was to investigate the effect of melatonin treatment on spermatogenesis and serum inflammatory cytokine levels in diabetic rats.Material and Method: Eighteen adult Wistar albino male rats were divided randomly into three groups each containing 6 rats; control group (group 1), diabetic group (group 2), diabetic treated with melatonin group (group 3). Experimental diabetes was obtained by administrating 50 mg/kg streptozotocin. Melatonin treatment was administered intraperitoneally for 7 days at a dose of 20 mg, daily. Serum levels of interleukin-1 beta (IL-1β), interleukin 6 (IL-6) and tumor necrosis factor-alpha (TNF-α) were assayed. Spermatogenesis was evaluated according to Johnsen score at immunopathological examination.Results: The Johnsen scores in control, diabetic and treatment groups were 9.78, 8.91, and 9.61, respectively. Spermatogenesis was negatively affected in diabetic rats and significantly improved with melatonin therapy (p

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Bu Makaleye Atıf Yap

EROL, H. S., AYDIN, M., ONK, D., GÜRSUL, C., BOZKURT, A., KARABAKAN, M., GUMUSTAS, S. (2022). Effects of melatonin treatment on the spermatogenesis and serum inflammatory cytokine levels in diabetic rats. Annals of Medical Research, Cilt: 26 - Sayı: 1, 12–16. https://ajindex.com/articles/446756

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Kaynakça (15)

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