SavedAdd your journal

Journals / Annals of Medical Research / 2020 / Cilt: 27 - Sayı: 9

Effects of Pelargonium sidoides (UMCA ®) on pulmonary contusion from blunt thoracic trauma in rats

Onur KARACA
Gul DOGAN
Ercan AYAZ
Güvenç DOGAN
Pages
2319–2325
Publication Date
2022-10-12
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Lung tissue samples were collected for histopathology.Results: Histopathologically, alveolar congestion, hemorrhage,edema,disruption and neutrophil infiltrationwere significantly higher in SG when compared with CG(p

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Aim: The aim of the present study was to evaluate the effect of Pelargonium sidoides (UMCA ®) which was antibacterial, antiviral, anti-inflammatory and antioxidant, on pulmonary contusion (PC) caused by isolated blunt thoracic trauma (BTT) in an experimental rat model.Material and Methods: A total of 24 rats were divided into three groups: control group (CG), sham group (SG), and Pelargonium sidoidesgroup (PSG).
📊
Key Findings & Data:Pelargonium sidoidestreatment was performed by gavage for 72 hours to the PSG after truma.
💡
Conclusion & Impact:Lung tissue samples were collected for histopathology.Results: Histopathologically, alveolar congestion, hemorrhage,edema,disruption and neutrophil infiltrationwere significantly higher in SG when compared with CG(p
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Aim: The aim of the present study was to evaluate the effect of Pelargonium sidoides (UMCA ®) which was antibacterial, antiviral, anti-inflammatory and antioxidant, on pulmonary contusion (PC) caused by isolated blunt thoracic trauma (BTT) in an experimental rat model.Material and Methods: A total of 24 rats were divided into three groups: control group (CG), sham group (SG), and Pelargonium sidoidesgroup (PSG). PC was induced by isolated BTT for all the groups except the control group. Pelargonium sidoidestreatment was performed by gavage for 72 hours to the PSG after truma. Blood and tissue samples were collected from the groups. Malondialdehyde(MDA), superoxide dismutase (SOD),glutathione (GSH) and arterial blood gas parameters were measured. Lung tissue samples were collected for histopathology.Results: Histopathologically, alveolar congestion, hemorrhage,edema,disruption and neutrophil infiltrationwere significantly higher in SG when compared with CG(p

🔖

Cite This Article

KARACA, O., DOGAN, G., AYAZ, E., DOGAN, G. (2022). Effects of Pelargonium sidoides (UMCA ®) on pulmonary contusion from blunt thoracic trauma in rats. Annals of Medical Research, Cilt: 27 - Sayı: 9, 2319–2325. https://ajindex.com/articles/446399

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (18)

  1. Altınok T. Akciğer Yaralanmaları. TTD Toraks Cerrahisi Bülteni 2010;1:55-9
  2. Peclet MH, Newman KD, Eichelberger MR, et al. Thoracic trauma in children: an indicator of increased mortality. J PediatrSurg 1990;25:961-6
  3. Wu XJ, Xia ZY, Wang LL, et al. Effects of phencyclidine hydrochloride on pulmonary contusion from blunt chest trauma in rats. Injury 2012;43:232-6
  4. Bliss D, Silen M. Pediatric thoracic trauma. Crit Care Med 2002;30:409-15
  5. Miller PR, Croce MA, Bee TK, et al. ARDS after pulmonary contusion: accurate measurement of contusion volume identifies high-risk patients. J Trauma 2001;51:223-30
  6. Cohn SM, Zieg PM. Experimental pulmonary contusion: review of the literature and description of a new porcine model. J Trauma Acute Care Surg 1996;41:565-71
  7. Kolodziej H. Fascinating metabolic pools of Pelargonium sidoides and Pelargonium reniforme, traditional and phytomedicinal sources of the herbal medicine Umckaloabo® Phytomedicine 2007;14:9-17
  8. Moyo M, Van Staden J. Medicinal properties and conservation of Pelargonium sidoides DC. J Ethnopharmacol 2014;152:243-55
  9. Kolodziej H, Kayser O, Radtke OA et al. Pharmacological profile of extracts of Pelargonium sidoides and their constituents. Phytomedicine 2003;10:18-24
  10. Turut H, Ciralik H, Kilinc M, et al. Effects of early administration of dexamethasone, N-acetylcysteine and aprotinin on inflammatory and oxidantantioxidant status after lung contusion in rats. Injury 2009;40:521-7
  11. Bao Y, Gao Y, Koch E, et al. Evaluation of Pharmacodynamic Activities of EPs® 7630, a Special Extract From Roots of Pelargonium Sidoides, in Animals Models of Cough, Secretolytic Activity and Acute Bronchitis. Phytomedicine 2015;22:504-9
  12. Raghavendran K, Davidson BA, Helinski JD, et al. A rat model for isolated bilateral lung contusion from blunt chest trauma.AnesthAnalg 2005;101:1482-9
  13. Calikoglu M, Tamer L, Sucu N, et al. The effects of caffeic phenethyl ester on tissue damage in lung after hind limb ischemia-reperfusion. Pharmaco- logical research 2003;48:397-403
  14. Jain SK, McVie R, Duett J et al. Erythrocyte membrane lipid peroxidation and glycosylated hemoglobin in diabetes. Diabetes 1989;38:1539-43
  15. Beutler E, Duron O, Kelly BM. Improved method for the determination of blood glutathione. J Lab Clin Med 1963;61:882-8
  16. Flohe L, Otting F. Superoxide dismutase assays. Methods in Enzymology 1984;105:93-104
  17. Jones K. Thoracic Trauma: Surg Clin North Am 1980;60:957-81
  18. Kolod