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Journals / Ankara Üniversitesi Veteriner Fakültesi Dergisi / 1997 / Cilt: 44 - Sayı: 2-3

The effect of vitamin D3 administration on parafollicular C cells, calcium, inorganic phosphorus and alkalin phosphatese concentrations in pregnant rats

Gebe ratlarda vitamin D3'ün tiroid parafoliküler (C) hücreleri, kalsiyum, inorganik fosfor ve alkalen fosfataz konsantrasyonuları üzerinde etkisi

Ayşin BAŞSATAN
Mustafa KAYMAZ
Ayhan BAŞTAN
Pages
193–199
Publication Date
2022-10-12
DOI
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Despite the marked increase in serum Ca and İP levels at 24 hours following the injection ofvit D3., there was a decline at 72 hours (p

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Objective & Hypothesis:The relationship between vitamin D3 and troid parafollicular C cells, calcium, inorganic phosphorus and alkalen phosphatase concentrations was investigated in pregnant rats.24 female Wistar albino rats, 11-13 weeks of age, were used in this study.
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Key Findings & Data:Group 1, group 2 and group 3 consisted of nonpregnant rats (n=8), 13 days pregnant rats (n=8) and 18 days pregnant rats (n=8) respectively. 20.000 m/kg vitamin D3 was administered by a single intramuscular injection to the all rats in experiment groups.
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Conclusion & Impact:Despite the marked increase in serum Ca and İP levels at 24 hours following the injection ofvit D3., there was a decline at 72 hours (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

The relationship between vitamin D3 and troid parafollicular C cells, calcium, inorganic phosphorus and alkalen phosphatase concentrations was investigated in pregnant rats.24 female Wistar albino rats, 11-13 weeks of age, were used in this study. Pregnant rats were determined by the presence of sperm in the vaginal smear. Group 1, group 2 and group 3 consisted of nonpregnant rats (n=8), 13 days pregnant rats (n=8) and 18 days pregnant rats (n=8) respectively. 20.000 m/kg vitamin D3 was administered by a single intramuscular injection to the all rats in experiment groups. Blood samples were collected at 24 and 72 hours after injection and serum calcium, inorganic phosphorus and alkaline phosphatase (ALP) levels have been determined. At 72 hours following the injection, troidectomy has been performed and troid glands were sent to the laboratory. Ionised calcium concentration was found to be higher in group 2 than assessed in group 3. Despite the marked increase in serum Ca and İP levels at 24 hours following the injection ofvit D3., there was a decline at 72 hours (p

Özet

Bu çalışmanın materyalini 11-13 haftalık 24 adet Wistar albino dişi rat oluşturdu. Gebe hayvanlar vaginal smear'de spermatozoon bulunması ile belirlendi. Gebe olmayan ratlar (n=8) Grup l'i, gebeliklerinin 13. gününde bulunanlar (n-8) Grup 2'yi ve 18 günlük gebe ratlar ise (n=8) Grup 3'ü oluşturdu. Her gruptaki hayvanlar kontrol (n=4) ve uygulama (n=4) alt gruplarına ayrıldı. Uygulama gruplarındaki tüm ratlara tek uygulama şeklinde 20.000 IU/kg VÜ-D3 kas içi yolla enjekte edildi. Kan örnekleri, enjeksiyon sonrası 24. ve 72.saatlerde alındı ve serumları çıkarılarak iyonize kalsiyum (Ca), inorganik fosfor (İP) ve alkalen fosfataz (ALP) değerleri saptandı. 72. Saatten.sonra radarın tiroid bezleri çıkarılarak laboratuvara gönderildi. Grup 2'de iyonize kalsiyum seviyesi Grup 3'de belirlenen düzeyden daha yüksek bulundu. Vitamin D3 uygulamasınıtakiben her 3 grupta da serum Ca ve İP düzeylerinde uygulama sonrası 24.saatte belirgin bir artış saptanırken 72. saatte, ise düşme saptandı (p

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Cite This Article

BAŞSATAN, A., KAYMAZ, M., BAŞTAN, A. (2022). The effect of vitamin D3 administration on parafollicular C cells, calcium, inorganic phosphorus and alkalin phosphatese concentrations in pregnant rats. Ankara Üniversitesi Veteriner Fakültesi Dergisi, Cilt: 44 - Sayı: 2-3, 193–199. https://ajindex.com/articles/445535

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