Journals / Ankara Üniversitesi Veteriner Fakültesi Dergisi / 2009 / Cilt: 56 - Sayı: 4

Determined of phytochemical properties of sainfoin (Onobrychis viciifolia) and acute orally LD50 in mice

Korunga bitkisinin (Onobrychis viciifolia) fitokimyasal içeriği ve farelerde akut oral ÖD50’sinin belirlenmesi

Pages
263–267
Publication Date
2022-10-12
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

We concluded that the acute toxicity of the plant orally administered to mice was low, which suggested that animal can consume safely it.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:This in vitro study was aimed to determine the phytochemical properties and acute $LD_{50}$ of oral administration of the extract of sainfoin (Onobrychis viciifolia) which is largely distributed in Turkey.
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Key Findings & Data:Sixty female and 60 male of total 120 numbers of wistar albino mice, 25-35g weight, approximately two months age were used to determine acute $LD_{50}$ level of the sainfoin extract.
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Conclusion & Impact:We concluded that the acute toxicity of the plant orally administered to mice was low, which suggested that animal can consume safely it.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

This in vitro study was aimed to determine the phytochemical properties and acute $LD_{50}$ of oral administration of the extract of sainfoin (Onobrychis viciifolia) which is largely distributed in Turkey. The phytochemical properties of the sainfoin extract were determined presence of alkaloids, saponins, tannins, peptide/proteins, sugars, amino acids, phenols and phenolic acid, choline and flavonoids. Sixty female and 60 male of total 120 numbers of wistar albino mice, 25-35g weight, approximately two months age were used to determine acute $LD_{50}$ level of the sainfoin extract. Acute oral $LD_{50}$ of sainfoin was found ≥19000 mg/kg for males and ≥20000 mg/kg for females and phytochemical analysis of the extract or plant showed the presence of tannins, amino acids, proteins, sucrose, phenolic contents; but the presence of alkaloids, simple sugars, saponins and choline were not observed. We concluded that the acute toxicity of the plant orally administered to mice was low, which suggested that animal can consume safely it.

Özet

Bu araştırmada, Türkiye’de yaygın bir şekilde yetiştirilen korunga bitkisinin (Onobrychis viciifolia) fitokimyasal içeriği ile ekstraktının farelerde ağızdan akut $ÖD_{50}$ miktarının belirlenmesi amaçlanmıştır. Korunga bitkisinin kimyasal incelemesinde; alkaloidlerin, saponinlerin, tanenlerin, peptid/proteinlerin, şekerlerin, aminoasitlerin, fenoller ve fenolik asitlerin, kolin ve flavonoidlerin varlığı araştırıldı. Akut $ÖD_{50}$ miktarının belirlenmesi için 25–35 g ağırlığında, yaklaşık 2 aylık Wistar Albino soyu, 60 dişi ve 60 erkek toplam 120 adet fare kullanıldı. Farelerde ağızdan akut $ÖD_{50}$ değerinin erkeklerde ≥19000 ve dişilerde ≥20000 mg/kg olduğu ve bitkinin veya ekstraktının fitokimyasal incelemesinde tanen, aminoasit, protein, sukroz, fenol ve flavonoidlerin olduğu, alkaloid, basit şeker, saponin ve kolin varlığının olmadığı gözlendi. Bitkinin farelerdeki ağızdan akut zehirliliğinin düşük olduğu ve hayvanlar tarafından güvenle tüketilebileceği sonucuna varılmıştır.

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Cite This Article

İNCE, S., FİLAZİ, A. (2022). Determined of phytochemical properties of sainfoin (Onobrychis viciifolia) and acute orally LD50 in mice. Ankara Üniversitesi Veteriner Fakültesi Dergisi, Cilt: 56 - Sayı: 4, 263–267. https://ajindex.com/articles/445073

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