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Journals / Ankara Üniversitesi Veteriner Fakültesi Dergisi / 2019 / Cilt: 66 - Sayı: 2

Effects of Allium tuncelianum on hyperglycemia and oxidative stress in the kidney and liver tissues in rats with diabetes mellitus induced by streptozotocin

Streptozotosin ile diyabetes mellitus oluşturulan sıçanlarda Allium tuncelianum’un hiperglisemi ve böbrek ve karaciğer dokularında oksidatif stres üzerine etkileri

Hamit USLU
Oktay ÖZKAN
Dinçer ERDAĞ
Gözde ATİLA
Ali Bilgili
Pages
185–190
Publication Date
2022-10-12
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Increased blood glucose levels (p

📌 3 Key Takeaways

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Objective & Hypothesis:In this study, it was aimed to investigate the effects of Allium tuncelianum extract on hyperglycemia and oxidative stress in the kidney and liver tissues in rats with diabetes mellitus induced by streptozotocin.
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Key Findings & Data:The rats were randomly divided into 4 groups with 10 animals in each group: Control group (C) was intraperitoneally (i.p.) treated with physiological saline solution, diabetic control (DC) group i.p. with a single dose of 50 mg/kg streptozotocin (STZ), diabetic + insulin (D+I) group i.p. with a single dose of 50 mg/kg STZ and subcutaneously (s.c.) with 2 IU insulin for 28 days (Levemir Flexpen), diabetic + Allium tuncelianum extract (D+AT) group i.p. with a single dose of 50 mg/kg STZ and orally with 250 mg/kg Allium tuncelianum extract for 28 days.
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Conclusion & Impact:Increased blood glucose levels (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

In this study, it was aimed to investigate the effects of Allium tuncelianum extract on hyperglycemia and oxidative stress in the kidney and liver tissues in rats with diabetes mellitus induced by streptozotocin. The rats were randomly divided into 4 groups with 10 animals in each group: Control group (C) was intraperitoneally (i.p.) treated with physiological saline solution, diabetic control (DC) group i.p. with a single dose of 50 mg/kg streptozotocin (STZ), diabetic + insulin (D+I) group i.p. with a single dose of 50 mg/kg STZ and subcutaneously (s.c.) with 2 IU insulin for 28 days (Levemir Flexpen), diabetic + Allium tuncelianum extract (D+AT) group i.p. with a single dose of 50 mg/kg STZ and orally with 250 mg/kg Allium tuncelianum extract for 28 days. The serum glycated hemoglobin (HbA1c), insulin levels and the kidney and liver thiobarbituric acid reactive substances (TBARS), superoxide dismutase (SOD), and catalase (CAT) activities were determined by using ELISA kits. Increased blood glucose levels (p

Özet

Bu çalışmada streptozotosin ile diyabetes mellitus oluşturulan sıçanlarda Allium tuncelianum ekstraktının hiperglisemi ve böbrek ve karaciğer dokularında oksidatif stres üzerine etkilerini araştırmak amaçlandı. Sıçanlar her bir grupta 10 hayvan olacak şekilde rastgele 4 gruba ayrıldı: Kontrol grubuna (C) periton içi (i.p.) fizyolojik tuzlu su, diyabetli kontrol (DC) grubuna i.p. tek doz 50 mg/kg streptozotosin (STZ), diyabet + insülin (D+I) grubuna i.p. tek doz 50 mg/kg STZ ve 28 gün süre ile deri altı (s.c.) 2 IU insülin (Levemir Flexpen), diyabet + Allium tuncelianum ekstrakt (D+AT) grubuna i.p. tek doz 50 mg/kg STZ ve 28 gün süre ile ağızdan 250 mg/kg Allium tuncelianum ekstraktı ugulandı. Serum glikozile hemoglobin (HbA1c), insülin düzeyleri ve böbrek ve karaciğer tiyobarbitürik asit reaktif maddeler (TBARS), süperoksit dismutaz (SOD) ve katalaz (CAT) aktiviteleri ELISA kitleri ile belirlendi. Kontrol grubuna göre diyabetli kontrol grubunda yüksek kan glikoz düzeyleri (p

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Cite This Article

USLU, H., ÖZKAN, O., ERDAĞ, D., ATİLA, G., Bilgili, A. (2022). Effects of Allium tuncelianum on hyperglycemia and oxidative stress in the kidney and liver tissues in rats with diabetes mellitus induced by streptozotocin. Ankara Üniversitesi Veteriner Fakültesi Dergisi, Cilt: 66 - Sayı: 2, 185–190. https://ajindex.com/articles/444516

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References (14)

  1. Abdultawab HS, Ayuob NN (2013): Can garlic oil ameliorate diabetes-induced oxidative stress in rat liver model? A correlated histological and biochemical study. Food Chem Toxicol, 59, 650-656
  2. Ahmed R (2005): The physiological and biochemical effects of diabetes on the balance between oxidative stress and antioxidant defense system. Med J Islam World Acad Sci, 15, 31-42
  3. Al-Qattan KK, Mansour MH, Thomson M, et al. (2016): Garlic decreases liver and kidney receptor for advanced glycation end products expression in experimental diabetes. Pathophysiology, 23, 135-145
  4. Anwar MM, Meki AR (2003): Oxidative stress in streptozotocin-induced diabetic rats: effects of garlic oil and melatonin. Comp Biochem Physiol A Mol Integr Physiol, 135, 539-547
  5. Aslan M, Orhan N, Deliorman Orhan D, et al. (2010): Hypoglycemic activity and antioxidant potential of some medicinal plants traditionally used in Turkey for diabetes. J Ethnopharmacol, 128, 384-389
  6. Augusti KT, Sheela CG (1996): Antiperoxide effect of S-allyl cysteine sulfoxide, an insulin secretagogue, in diabetic rats. Experientia, 52, 115-120
  7. Ayodhya S, Kusum S, Anjali S (2010): Hypoglycemic activity of different extracts of various herbal plants. Int J Ayurveda Res Pharm, 1, 212-224
  8. Badole SL, Ghule AE, Wagh NK (2013): Antidiabetic activity of Allium sativum. Bioactive food as dietary interventions for diabetes,
  9. Baluchnejadmojarad T, Kiasalari Z, Afshin-Majd S, et al. (2017): S-allyl cysteine ameliorates cognitive deficits in streptozotocin-diabetic rats via suppression of oxidative stress, inflammation, and acetylcholinesterase. Eur J Pharmacol, 794, 69-76
  10. Bombicino SS, Iglesias DE, Rukavina-Mikusic IA, et al. (2017): Hydrogen peroxide, nitric oxide and ATP are molecules involved in cardiac mitochondrial biogenesis in Diabetes. Free Radic Biol Med, 112, 267-276
  11. Chawla A, Chawla R, Jaggi S (2016): Microvascular and macrovascular complications in diabetes mellitus: Distinct or continuum? Indian J Endocrinol Metab, 20, 546-551
  12. Chung SS, Ho EC, Lam KS, et al. (2003): Contribution of polyol pathway to diabetes-induced oxidative stress. J Am Soc Nephrol, 14, S233-236
  13. Dorotea D, Kwon G, Lee JH, et al. (2018): A pan-NADPH oxidase inhibitor ameliorates kidney injury in type 1 diabetic rats. Pharmacology, 102, 180-189
  14. Gdula-Argasinska J, Pasko P, Sulkowska-Ziaja K, et al. (2017): Anti-inflammatory activities of garlic