Journals / Ankara Üniversitesi Tıp Fakültesi Mecmuası / 2021 / Cilt: 74 - Sayı: 1

Laboratory Parameters Predicting Mortality in Heart Failure Patients treated with Implantable Cardioverter Defibrillator: Single Centre, Long-term Results

Takılabilir Kardiyoverter Defibrilatör ile Tedavi Edilen Kalp Yetersizliği Hastalarında Mortaliteyi Belirleyen Laboratuvar Paramaterleri: Tek Merkezli, Uzun Dönemli Sonuçlar

Pages
83–89
Publication Date
2022-10-10
DOI
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⚡ TL;DR(Too Long; Didn't Read)

While the rates of NLR, MHR and PLR were statistically significantly higher in the group with death during follow-up (p=0.001, p=0.049, p=0.020, respectively ), LMR was significantly lower (p

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives: Neutrophil/lymphocyte (NLR), Monocyte/HDL (MHR), lymphocyte/monocyte (LMR) and platelet/lymphocyte ratios (PLR) are inflammation markers with proven prognostic values in various cardiovascular diseases.
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Key Findings & Data:It is aimed to demonstrate the relationship between NLR, MHR, LMR, PLR and mortality development in patients with HF with ICD.
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Conclusion & Impact:While the rates of NLR, MHR and PLR were statistically significantly higher in the group with death during follow-up (p=0.001, p=0.049, p=0.020, respectively ), LMR was significantly lower (p
🔬Design:Research Article
📍Scope:2015 Verileri
⚙️Variables:Domain Parameters

Abstract

Objectives: Neutrophil/lymphocyte (NLR), Monocyte/HDL (MHR), lymphocyte/monocyte (LMR) and platelet/lymphocyte ratios (PLR) are inflammation markers with proven prognostic values in various cardiovascular diseases. However, a clinical study demonstrating the prognostic value of these markers in heart failure (HF) patients treated with an implantable cardioverter-defibrillator (ICD) is not yet available. It is aimed to demonstrate the relationship between NLR, MHR, LMR, PLR and mortality development in patients with HF with ICD. Materials and Methods: One hundred and ninety-four patients who underwent ICD implantation due to systolic HF between January 2015 and December 2019 were included in the study. Results: The mean age was 59.84±13.26 years. The female gender ratio was 25.3%. Death developed in 16 patients (8%) after a median follow-up of 27 months. While basal urea, uric acid, gamma-glutamyl transferase, C-reactive protein and neutrophil levels were found to be high, hemoglobin and lymphocyte levels were found to be low in the exitus developing group. While the rates of NLR, MHR and PLR were statistically significantly higher in the group with death during follow-up (p=0.001, p=0.049, p=0.020, respectively ), LMR was significantly lower (p

Özet

Amaç: Nötrofil/lenfosit oranı (NLR), Monosit/HDL oranı (MHR), lenfosit/monosit oranı (LMR) ve platelet/lenfosit oranı (PLR) kardiyovasküler hastalıklarda prognostik değerleri kanıtlanmış olan enflamasyon belirteçleridir. Fakat bu belirteçlerin takılabilir kardiyoverter defibrillator (ICD) ile tedavi edilen kalp yetersizliği hastalarında prognostik değerini gösteren klinik çalışma henüz mevcut değildir. Bu çalışmada NLR, MHR, LMR, PLR oranları ile ICD’si olan kalp yetersizliği hastalarında mortalite gelişimi arasındaki ilişkinin gösterilmesi amaçlanmıştır. Gereç ve Yöntem: Çalışmaya, Ocak 2015-Aralık 2019 tarihleri arasında sistolik kalp yetersizliği nedeniyle ICD implantasyonu yapılmış 194 hasta dahil edildi. Bulgular: Hastaların ortalama yaşı 59,84±13,26 idi. Kadın cinsiyet oranı %25,3 idi. Medyan 27 aylık izlem sonrasında 16 hastada ölüm gelişti (%8). Exitus gelişen grupta bazal üre, ürik asit, gama-glutamil transferaz, C-reaktif protein, nötrofil düzeyleri yüksek saptanırken; hemoglobin ve lenfosit düzeyleri ise düşük saptandı. Takiplerde ölüm gelişen grupta NLR, MHR ve PLR oranları istatistiksel olarak anlamlı şekilde yüksek saptanırken (p=0,001, p=0,049, p=0,020, sırasıyla) LMR belirgin derecede düşük saptanmıştır (p

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Cite This Article

SAKALLI, S., BARIŞ, V. Ö., BÜYÜK, A., POYRAZ, F., GÜNEY, M. C. (2022). Laboratory Parameters Predicting Mortality in Heart Failure Patients treated with Implantable Cardioverter Defibrillator: Single Centre, Long-term Results. Ankara Üniversitesi Tıp Fakültesi Mecmuası, Cilt: 74 - Sayı: 1, 83–89. https://ajindex.com/articles/443440

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References (10)

  1. Ponikowski P, Voors AA, Anker SD, et al. 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC)Developed with the special contribution of the Heart Failure Association (HFA) of the ESC. Eur Heart J 2016;37:2129-2200
  2. Aukrust P, Ueland T, Lien E, et al. Cytokine network in congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy. Am J Cardiol. 1999;83:376-382
  3. McMurray JJ, Packer M, Desai AS, et al. Angiotensin-neprilysin inhibition versus enalapril in heart failure. N Engl J Med. 2014;371:993-1004
  4. Ganjali S, Gotto AM Jr, Ruscica M, et al. Monocyte-to-HDL-cholesterol ratio as a prognostic marker in cardiovascular diseases. J Cell Physiol. 2018;233:9237-9246
  5. Abdul-Rahim AH, Perez AC, Fulton RL, et al. Risk of Stroke in Chronic Heart Failure Patients Without Atrial Fibrillation: Analysis of the Controlled Rosuvastatin in Multinational Trial Heart Failure (CORONA) and the Gruppo Italiano per lo Studio della Sopravvivenza nell’Insufficienza Cardiaca-Heart Failure (GISSI-HF) Trials. Circulation. 2015;131:1486-1494
  6. Priori SG, Blomström-Lundqvist C, Mazzanti A, et al. 2015 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: The Task Force for the Management of Patients with Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death of the European Society of Cardiology (ESC). Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC). Eur Heart J. 2015;36:2793-2867
  7. Bardy GH, Lee KL, Mark DB, et al. Amiodarone or an implantable cardioverterdefibrillator for congestive heart failure. N Engl J Med. 2005;352:225-237
  8. Uthamalingam S, Patvardhan EA, Subramanian S, et al. Utility of the neutrophil to lymphocyte ratio in predicting long-term outcomes in acute decompensated heart failure. Am J Cardiol. 2011;107:433-438
  9. Ertem AG, Yayla C, Acar B, et al. Relation between lymphocyte to monocyte ratio and short-term mortality in patients with acute pulmonary embolism. Clin Respir J. 2018;12:580-586
  10. Villanueva DLE, Tiongson MD, Ramos JD, et al. Monocyte to High-Density Lipoprotein Ratio (MHR) as a predictor of mortality and Major Adverse Cardiovascular Events (MACE) among ST Elevation Myocardial Infarction (STEMI) patients undergoing primary percutaneous coronary