The chemical structures of the compounds were elucidated by IR, 'H-NMR and elemental analysis.
📌 3 Key Takeaways
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Objective & Hypothesis:In this study, seven new 6-acyl-5-chloro-2-benzoxazolinone derivatives having a pipemzinomethyl (or piperidinomethyl) group at the third position of the ring were synthesized by using appropriate benzoxazolinones and 4-substituted piperazines (or 4-substituted piperidines) via a Mannich reaction.
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Key Findings & Data:In this study, seven new 6-acyl-5-chloro-2-benzoxazolinone derivatives having a pipemzinomethyl (or piperidinomethyl) group at the third position of the ring were synthesized by using appropriate benzoxazolinones and 4-substituted piperazines (or 4-substituted piperidines) via a Mannich reaction.
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Conclusion & Impact:The chemical structures of the compounds were elucidated by IR, 'H-NMR and elemental analysis.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters
Abstract
In this study, seven new 6-acyl-5-chloro-2-benzoxazolinone derivatives having a pipemzinomethyl (or piperidinomethyl) group at the third position of the ring were synthesized by using appropriate benzoxazolinones and 4-substituted piperazines (or 4-substituted piperidines) via a Mannich reaction. The chemical structures of the compounds were elucidated by IR, 'H-NMR and elemental analysis.
Özet
Bu çalışmada, 3 numaralı konumda piperazinometil (veya piperidinometil) grubu taşıyan 6-açil-5-chloro-2-benzoksazolinon türevi yedi tane yeni bileşik, uygun benzoksazolinonlar ve 4-sübstitüe piperazin (veya 4-sübstitüe piperidin) kullanılarak Mannich reaksiyonuyla sentezlenmiştir. Bileşiklerin kimyasal yapıları İR, 'H-NMR ve elemental analizleriyle kanıtlanmıştır.
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Cite This Article
ÖZKANLI, F. (2022). Bazı yeni Mannich bazı 6-açil-5-kloro-2-benzoksazolinonların sentezleri. Ankara Üniversitesi Eczacılık Fakültesi Dergisi, Cilt: 33 - Sayı: 2, 85–90. https://ajindex.com/articles/442532
Cain, C.K., Poszkowski, A.P., Psychopharmacological Agents, Vol. 1, Academic Press, New york, p.329 (1964)
Wahlroos, 0.,Virtanen, A.I. "Antifungal effect of benzoxazolinone and 6-methoxybenzoxazolinone on Fusarium nivale",Acta Chem.Scand. 12, J 24-8 (1958)
Varma, R., Nobles, W. "Synthesis and Antibacterial Activity of Certain 3-Substituted Benzoxazolinones" J.Pharm.ScL, 57, 39-44 (1968)
Pilli, G., Erdoğan, H., Suna J R. "Some New Benzoxazolinone-3-yl)alkanoic Acid Derivatives with Analgesic and Antiinflammatory Activities" Arzneim.-ForschJ Drug Res., 43(11), 1351-1354(1993)
Gökhan, N., Erdoğan, H., Tel, B.C., Demirdamar, R. "Analgesic and Antiinflammatory Activity Screening of 6-Acyl-3-piperazinomethyl-2-benzoksazolinone Derivatives" Eur. J. Med. Chem.3, 625-628 (1996)
Gökhan, N., Erdoğan, H., TeJ B., Denıirdamar, R. "Synthesis and Evaluation of Analgesic, Antiinflammatory and Antimicrobial Activities of 6-Acyl-3-Piperazinomethyl-2-Benzoxazolinones" Arzneim.-ForschJDrug Res., 53(2), 114-120(2003)
Erdoğan, H., Ünlii, S., Suna,I R. "Analgesic Activity of Some 3-(Arylpiperidinomethyl)-2-Benzoxazolinone Derivatives" Arch. Pharm., 322, 75-78 (1989)
Gökhan, N., Erdoğan, H., Durlu, T., Sunal, R. "Novel Antiinflammatory Analgesics:3-(2-/4-Pyridylethyl)-Benzoxazolinone and Oxazolo[4,5-b]pyridin-2-one Derivatives" Archiv. Pharm., 332(2), 43-49 (1999)
Palaska, E., Ünlü, S., Özkanlı, F., Pilli, G., Erdoğan, H., Şafak, C., Demirdamar, R., Gümüşe), B., Duru, S. "3-Substituted PiperazinomethylBenzoxazolinones: Analgesic and Antiinflammatory Compounds Inhibiting Prostaglandin E2 " Arzneim.-ForschJDrug Res., 45(1), 6,693-696 (1995)
Bermann, M.C., Bonte, J.P., Lesieur-Demarquilly, I., Debaert, M. Pharmacomodulation of the Benzoxazoliinone Model by Aryl-piperazine Structure
Ferrand, G., Dumas, H., Depin, J.C., Chavernac, G. "Synthese et Activite Antidepresive potentielle de nouvelles triazine-1,2,3 ones 4 " EurJ.Med.Chem., 22, 337-345 b (1987)
Nakao, T., Anami, K., Yamamoto, Y., Jpn. Kokai Tokyo Koho JP01,106,868, 1989; Chem Abstr. 111,194797u (1989)
Gökhan, N., Erdoğan, H., Durlu, T., Sunal, R. "Analgesic Activity of Acylated 2 Benzoxazolinone Derivatives" II Farmaco,54,112-115(1999)
Bonte, J.P., Lesieur, D., Lespagnol, C., Plat, M., Cazin, J.C., Cazin, M. "Acyl-6 Benzoxazolinones" Eur. J. Med. Chem.-Chim. Ther., 9(5), 491-497 (1974)
Aichaoui, H., Lesieur, D., Henichart, J.P. "A Convenient and Effient Met