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Journals / Ankara Üniversitesi Eczacılık Fakültesi Dergisi / 2004 / Cilt: 33 - Sayı: 2

N-sübstitüe indol-2 ve 3-karboksamitlerin antioksidan aktivitesi

Antioxidant activity of N--substituted indole-2 and 3-carboxamides

Süreyya ÖLGEN
Tülay ÇOBAN
Pages
109–116
Publication Date
2022-10-10
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Both activity results show that these compounds are promising antioxidants.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:A series of N-substituted indole amide derivatives was tested for in vitro effects on rat liver microsomal NADPH-dependent lipid peroxidation (LP) and superoxide anion (SOD) formation.
📊
Key Findings & Data:Vitamin E (a-tocopherol) decreased the LP level by about 63% at 104 M concentration.
💡
Conclusion & Impact:Both activity results show that these compounds are promising antioxidants.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

A series of N-substituted indole amide derivatives was tested for in vitro effects on rat liver microsomal NADPH-dependent lipid peroxidation (LP) and superoxide anion (SOD) formation. Vitamin E (a-tocopherol) decreased the LP level by about 63% at 104 M concentration. A significant decrease in male liver microsomal LP level was noted for the compounds 1, 8 and W at a concentration of 10'4M comparing with a-tocopherol. The inhibition of O2(~ by compounds 8 and 10 were found highly efficient. Both activity results show that these compounds are promising antioxidants.

Özet

Bir seri N-sübstitüe indol amid türevinin, sıçan karaciğerinden elde edilen mikrozomal NADP'ye bağımlı lipid peroksidasyon (LP) ve süperoksit anyon şekillenmesi üzerinde olan invitro etkileri test edildi. Vitamin E (a-tokoferol), LP seviyesini W4 M konsantrasyonda yaklaşık % 63 kadar azalttı. Bileşiklerden 1,8 ve 10'ün 104 M konsantrasyonda, a-tokoferol ile karşılaştırıldıklarında erkek karaciğer mikrozomal LP düzeylerinde belirgin bir azalmaya neden olduğu bulundu. Bileşiklerden 8 ve 10'ün. O/ anyonunu belirgin bir biçimde inhibe ettiği bulundu. Her iki aktivite sonucu, bu bileşiklerin ümit verici antioksidanlar olabileceklerini gösterdi.

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Cite This Article

ÖLGEN, S., ÇOBAN, T. (2022). N-sübstitüe indol-2 ve 3-karboksamitlerin antioksidan aktivitesi. Ankara Üniversitesi Eczacılık Fakültesi Dergisi, Cilt: 33 - Sayı: 2, 109–116. https://ajindex.com/articles/442529

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References (11)

  1. Shen, T. Y., Winter, C. A. "Chemical And Biological Studies On Indomethacin, Sulindac And Their Analogs "Advances İn Drug Research, 12, 89 (1977)
  2. Unangst, P. C., Conner, D. T., Stabler, R. S., Weikert, R. J., Carethers, M. E., Kennedy, J. A., Thueson, D. O., Chesnut, J. C., Adolphson, R. L. Conroy, M. C. "Novel Indolecarboxamidotetrazoles As Potential Antiallergy Agents" J. Med. Chem. 32, 1360(1989)
  3. Williams, T. M., Ciccarone, T. M., Mactough, S. C., Rooney, C. S., Balani, S. K., Condra, J. H., Emini, E. A., Goldman, M. E., Greenlee, W. J., Kauffman, L. R., O'brien, J. A., Sardana, V. V., Schleif, W. A., Theoharides, A. D., Anderson, P. S. "5-Chloro-3-(Phenylsulfonyl)İndole-2-Carboxamide: A Novel, Non-Nucleoside inhibitor Of Hiv-1 Reverse Transcriptase" J. Med. Chem. 36, 1291 (1993)
  4. Kelly, T. A., Mcneil, D. W., Rose, J. M., David, E., Shih, C. K., Grob, P. M. "Novel Non-Nucleoside inhibitors Of Human immunodeficiency Virus Type 1 Reverse Transcriptase. 6. 2-İndol-3-Yl- And 2-Azaindol-3-Yl-Dipyridodiazepinones" J. Med. Chem. 40, 2430 (1997)
  5. Mendel, D. B., Laird, A. D., Smolich, B. D., Blake, R. A., Liang, C., Hannah, A. L., Shaheen, R. M., Ellis, L. M., Weitman, S., Shawver, L. K., Cherrington, J. M. "Development Of Su5416, A Selective Small Molecule inhibitor Of Vgef Receptor Thyrosine Kinase Activity, As An Anti-Angiogenesis Agent" Anti-Cancer Drug Design, 15,29 (2000)
  6. Cirrincione, G., Almerico, A. M., Barraja, P., Diana, P., Lauria, A., Passannanti, A.,Musiu, C., Pani, A., Murtas, P., Minnei, C., Marongui, M. E., Lacolla, P. "Derivatives Of The New Ring System İndolofl,2-C]Benzo[l,2,3]Triazine With Potent Antitumor And Antimicrobial Activity" J. Med. Chem. 42,2561 (1999)
  7. Kim, D. H., Guinosso, C. J., Buzby, G. C., Herbst, D. R., Mccaully, R. J. "Mercaptopropanoyl İndoline-2-Carboxylic Acids And Related Compounds As Potent Angiotensin Converting Enzyme inhibitors And Antihypertansive Agents" J. Med. Chem. 26,394(1983)
  8. Antosiewich, J., Damiani, E., Jassem, W., Wozniak, M., Orena, M., Greci, L. "Influence Of Structure On The Antioxidant Activity Of İndolinic Nitroxide Radicals" Free Radical Biology And Medicine, 22, 249 (1997)
  9. Sreejayan, N. Rao, M. N. A."Free Radical Scavenging Activity Of Curcuminoids" Arzneim Forsch J Drug Res, 46, 169 (1996)
  10. Ölgen, S., Çoban, T. "Synthesis And Antioxidant Properties Of Novel N- Substituted Indole 2-Carboxamide And 3-Acetamide Derivatives" Arch, Pharm. 335, 331 (2002)
  11. Ölgen,