SavedAdd your journal

Journals / Ankara Medical Journal / 2018 / Cilt: 18 - Sayı: 2

Therapy Resistant Hypothyroidism

Tedaviye Dirençli Hipotiroidi

Bekir ÇAKIR
Oya TOPALOĞLU
Pages
235–241
Publication Date
2022-10-12
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In these patients, primarily non-adherence to the therapy should be remembered and then, whether there is an underlying reason or not should be investigated.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Hypothyroidism is a common problem in the population.
📊
Key Findings & Data:Standard therapy for hypothyroidism is the replacement with synthetic L-thyroxine (L-T4) sodium preparations.
💡
Conclusion & Impact:In these patients, primarily non-adherence to the therapy should be remembered and then, whether there is an underlying reason or not should be investigated.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Hypothyroidism is a common problem in the population. Standard therapy for hypothyroidism is the replacement with synthetic L-thyroxine (L-T4) sodium preparations. The target of the treatment is to maintain TSH levels between normal reference values. Detection of the underlying reason can be difficult in patients with higher L-T4 dose requirement than expected. In these patients, primarily non-adherence to the therapy should be remembered and then, whether there is an underlying reason or not should be investigated.

Özet

Hipotiroidi toplumda sık görülen bir problemdir. Hipotiroidinin standart tedavisi sentetik L-tiroksin (L-T4) sodyum preparatları ile replasmandır. Tedavide hedef TSH’ yı normal referans değerleri arasında tutmaktır. Beklenen dozların üzerinde L-T4 gereksinimi olan hastalarda altta yatan nedeni tespit etmek zor olabilir. Bu hastalarda öncelikli olarak ilaç alımında uyumsuzluk düşünülmeli ve sonra da altta yatan biyolojik bir neden olup olmadığı da araştırılmalıdır.

🔖

Cite This Article

ÇAKIR, B., TOPALOĞLU, O. (2022). Therapy Resistant Hypothyroidism. Ankara Medical Journal, Cilt: 18 - Sayı: 2, 235–241. https://ajindex.com/articles/442005

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (16)

  1. Jonklaas J, Bianco AC, Bauer AJ et al. Guidelines for the treatment of hypothyroidism. Thyroid 2014;24(12):1670-751
  2. Türkiye Endokrinoloji ve Metabolizma Derneği, Tiroid Hastalıkları Tanı ve Tedavi Kılavuzu, Ankara: Ortadoğu Reklam Tanıtım Yayıncılık; 2017
  3. Read DG, Hays MT, Hershman JM. Absorption of oral thyroxine in hypothyroid and normal man. J Clin Endocrinol Metab 1970;30:798-9
  4. Centanni M, Benvenga S, Sachmechi I. Diagnosis and management of treatment refractory hypothyroidism: an expert consensus report. J Endocrinol Invest 2017;40:1289-301
  5. Vaisman F, Coeli CM, Ward LS et al. How good is the levothyroxine replacement in primary hypothyroidism patients in Brasil? Data of a multicentre study. J Endocrinol Invest 2013;36:485-8
  6. Morris LS, Schulz RM. Medication compliance: the patient’s perspective. Clin Therapeutics 1993;15:593-606
  7. Lips DJ, van Reisen MT, Voigt V, Venekamp W. Diagnosis and treatment of levothyroxine pseudomalabsorption. Netherlands J Med 2004;62:114-8
  8. Grebe SK, Cooke RR, Ford HC et al. Treatment of hypothyroidism with once weekly thyroxine. J Clin Endocrinol Metab 1997;82(3):870-5
  9. Garber JR, Cobin RH, Gharib H et al. Clinical Practice Guidelines for hypothyroidism in Adults: Cosponsored by the American Association of Clinical Endocrinologists and the American Thyroid Association. Thyroid 2012;22:1200-35
  10. Mc Dermott JH, Coss A, Walsh JH. Case History: Celiac disease presenting as resistant hypothyroidism. Thyroid 2005;15(4):386-8
  11. Virili C, Bassotti G, Santaguida MG et al. Atypical celiac disease as cause of increased need for thyroxine: A systematic study. J Clin Endocrinol Metab 2012;97(3):419-22
  12. Zubarik R, Ganguly E, Nathan M, Vecchio J. Celiac disease detection in hypothyroid patients requiring elevated thyroid supplementation: A prospective cohort study. Eur J Intern Med 2015; 26(10): 825-9
  13. Cellini M, Santaguida MG, Gatto I et al. Systemic appraisal of lactose intolerance as cause of increased need for oral thyroxine. J Clin Endocrinol Metab 2014;99(8):1454-8
  14. Asik M, Gunes F, Binnetoglu E et al. Decrease in TSH levels after lactose restriction in Hashimoto’s thyroiditis patients with lactose intolerance. Endocrine 2014;46:279-84
  15. Centanni M, Gargano L, Canettieri G et al. Thyroxine in goiter, Helicobacter pylori infection, and chronic gastritis. N Engl J Med 2006;354:1787-95
  16. Benvenga S, Papi G, Antonelli A. Refractory hypothyroidism due to improper storage of levothyro