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Journals / Ankara Medical Journal / 2022 / Cilt: 22 - Sayı: 3

Less Known and Neglected Renal Complication of Primary Hyperparathyroidism: Renal Cysts

Şefika Burçak POLAT
Leyla AKDOĞAN
Müge KESKİN
Gökhan YÜCE
Berna EVRANOS ÖĞMEN
Oya TOPALOĞLU
Bekir ÇAKIR
Pages
415–423
Publication Date
2022-10-12
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: Simple renal cysts are a benign renal complication of PHPT that does not alter renal function significantly, and their presence is directly correlated with the hypersecretion of PTH.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objectives: Simple renal cysts are lesions that are epithelial in origin, with a prevalence changing between 5 to 15% in the normal population.
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Key Findings & Data:Materials and Methods: A total of 307 PHPT patients and 112 healthy controls were enrolled in our study.
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Conclusion & Impact:Conclusion: Simple renal cysts are a benign renal complication of PHPT that does not alter renal function significantly, and their presence is directly correlated with the hypersecretion of PTH.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objectives: Simple renal cysts are lesions that are epithelial in origin, with a prevalence changing between 5 to 15% in the normal population. In animal studies, it was shown that PTH might stimulate cyst formation via intracellular signaling systems triggering epithelial cell proliferation. Our primary aim was to detect the simple cyst prevalence in a large cohort of PHPT and compare it with sex and age-matched health individuals. The secondary aim was to detect determinants of cyst formation in PHPT. Materials and Methods: A total of 307 PHPT patients and 112 healthy controls were enrolled in our study. PHPT group was compared with the control group regarding the biochemical parameters and presence, size and bilaterality of renal cysts in the US performed by a single experienced radiologist. Results: Prevalence (43.65% vs 25%, p=0.020) and size [28.40 mm (min-max: 4-82) vs 12.20 mm (min-max: 3-94) (p=0.013)] of simple renal cysts were higher in the PHPT group compared to controls. The presence of renal cysts was correlated with age but not sex and positively correlated with the serum PTH level in regression analysis. Serum Ca, P, and 24-hour urinary Ca excretion were not found to be associated with cyst formation. Conclusion: Simple renal cysts are a benign renal complication of PHPT that does not alter renal function significantly, and their presence is directly correlated with the hypersecretion of PTH.

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Cite This Article

POLAT, Ş. B., AKDOĞAN, L., KESKİN, M., YÜCE, G., ÖĞMEN, B. E., TOPALOĞLU, O., ÇAKIR, B. (2022). Less Known and Neglected Renal Complication of Primary Hyperparathyroidism: Renal Cysts. Ankara Medical Journal, Cilt: 22 - Sayı: 3, 415–423. https://ajindex.com/articles/441688

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