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Journals / Ankara Medical Journal / 2022 / Cilt: 22 - Sayı: 2

NORMOCALCEMIC PRIMARY HYPERPARATHYROIDISM IS NOT INNOCENT AS IT SOUNDS

Şefika Burçak POLAT
Pages
239–248
Publication Date
2022-10-12
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

These findings suggest that the frequency of surgical indications is similar.

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives: Primary hyperparathyroidism (PHPT) is the most common cause of hypercalcemia.
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Key Findings & Data:The data of PHPT operated patients were retrospectively analyzed, and biochemical and clinical characteristics of hypercalcemic and normocalcemic patients were compared.
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Conclusion & Impact:These findings suggest that the frequency of surgical indications is similar.
🔬Design:Research Article
📍Scope:2012 Verileri
⚙️Variables:Domain Parameters

Abstract

Objectives: Primary hyperparathyroidism (PHPT) is the most common cause of hypercalcemia. A group of patients who were admitted with PHPT and had normal calcium levels with high parathyroid hormone (PTH) levels was defined as normocalcemic PHPT (NPHPT). The data of PHPT operated patients were retrospectively analyzed, and biochemical and clinical characteristics of hypercalcemic and normocalcemic patients were compared. Materials and Methods: The data of patients diagnosed with PHPT between January 2012 and January 2019 were retrospectively evaluated. A total of 318 patients were divided into two subgroups, hypercalcemic and normocalcemic, according to their calcium level. The two groups were compared regarding clinical and biochemical properties. Results: Female gender was dominant in both groups (P = 0.072). The mean age was similar in both groups (P = 0.362). As expected, serum corrected calcium (Ca), PTH levels, and urinary Ca excretion were higher in the hypercalcemia group (P < 0.001). There was no difference between the two groups in alkaline phosphatase, creatinine, and vitamin D levels. The percentage of localization with preoperative was similar. Also, there was no difference in adenoma features (echogenicity, cystic appearance) and localization on ultrasonography (US). The positive result obtained on neck MRI and MIBI scanning was similar. There was no difference between the two groups in terms of kidney stone and osteoporosis prevalence. Conclusion: In our cohort, the NHPT phenotype was found to be like the hypercalcemic group. These findings suggest that the frequency of surgical indications is similar.

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Cite This Article

POLAT, Ş. B. (2022). NORMOCALCEMIC PRIMARY HYPERPARATHYROIDISM IS NOT INNOCENT AS IT SOUNDS. Ankara Medical Journal, Cilt: 22 - Sayı: 2, 239–248. https://ajindex.com/articles/441669

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